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Molecular Cancer Therapeutics
Molecular Cancer Therapeutics

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About the Cover

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ABOUT THE COVER
Toward examining impacts of the tumor microenvironment on cancer drug delivery, Lee and colleagues applied Transparent Tissue Tomography (T3) as a new tool to visualize macromolecules in situ. The cover is adapted from a detail of a T3 snapshot of immunotherapy, showing a section of tumor excised minutes after injecting anti-PD-L1. Antibody (red) flows through the microvasculature (CD31+, cyan) and extravasates to bind to its target (PD-L1, magenta) on cancer cells (Her2+, green), reactivating cytotoxic T lymphocytes (CD8+, yellow) to restore anti-tumor immune response. For details, see article on page 213.

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Molecular Cancer Therapeutics: 18 (1)
January 2019
Volume 18, Issue 1
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Issue Highlights

  • KRAS and EGFR Amplifications Mediate Resistance to Rociletinib and Osimertinib in Acquired Afatinib-Resistant NSCLC Harboring Exon 19 Deletion/T790M in EGFR
  • Targeting of Hematologic Malignancies with PTC299, A Novel Potent Inhibitor of Dihydroorotate Dehydrogenase with Favorable Pharmaceutical Properties
  • The Increased Expression of Estrogen-Related Receptor α Correlates with Wnt5a and Poor Prognosis in Patients with Glioma
  • Multiplex Three-Dimensional Mapping of Macromolecular Drug Distribution in the Tumor Microenvironment
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Copyright © 2019 by the American Association for Cancer Research.

Molecular Cancer Therapeutics
eISSN: 1538-8514
ISSN: 1535-7163

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