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Molecular Cancer Therapeutics
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Small Molecule Therapeutics

Efficacy of the MDM2 Inhibitor SAR405838 in Glioblastoma Is Limited by Poor Distribution Across the Blood–Brain Barrier

Minjee Kim, Daniel J. Ma, David Calligaris, Shuangling Zhang, Ryan W. Feathers, Rachael A. Vaubel, Isabelle Meaux, Ann C. Mladek, Karen E. Parrish, Fang Jin, Cedric Barriere, Laurent Debussche, James Watters, Shulan Tian, Paul A Decker, Jeanette E. Eckel-Passow, Gaspar J. Kitange, Aaron J. Johnson, Ian F. Parney, Panos Z. Anastasiadis, Nathalie Y.R. Agar, William F. Elmquist and Jann N. Sarkaria
Minjee Kim
1University of Minnesota, Minneapolis, Minnesota.
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Daniel J. Ma
2Mayo Clinic, Rochester, Minnesota.
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David Calligaris
3Brigham and Women's Hospital, Boston, Massachusetts.
4Harvard Medical School, Boston, Massachusetts.
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Shuangling Zhang
1University of Minnesota, Minneapolis, Minnesota.
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Ryan W. Feathers
5Mayo Clinic, Jacksonville, Florida.
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Rachael A. Vaubel
2Mayo Clinic, Rochester, Minnesota.
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  • ORCID record for Rachael A. Vaubel
Isabelle Meaux
6Sanofi Oncology, Vitry-sur-Seine, France.
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Ann C. Mladek
2Mayo Clinic, Rochester, Minnesota.
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Karen E. Parrish
1University of Minnesota, Minneapolis, Minnesota.
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Fang Jin
2Mayo Clinic, Rochester, Minnesota.
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Cedric Barriere
6Sanofi Oncology, Vitry-sur-Seine, France.
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Laurent Debussche
6Sanofi Oncology, Vitry-sur-Seine, France.
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James Watters
6Sanofi Oncology, Vitry-sur-Seine, France.
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Shulan Tian
2Mayo Clinic, Rochester, Minnesota.
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Paul A Decker
2Mayo Clinic, Rochester, Minnesota.
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Jeanette E. Eckel-Passow
2Mayo Clinic, Rochester, Minnesota.
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Gaspar J. Kitange
2Mayo Clinic, Rochester, Minnesota.
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Aaron J. Johnson
2Mayo Clinic, Rochester, Minnesota.
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Ian F. Parney
2Mayo Clinic, Rochester, Minnesota.
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Panos Z. Anastasiadis
5Mayo Clinic, Jacksonville, Florida.
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Nathalie Y.R. Agar
3Brigham and Women's Hospital, Boston, Massachusetts.
4Harvard Medical School, Boston, Massachusetts.
7Dana Farber Cancer Institute, Boston, Massachusetts.
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William F. Elmquist
1University of Minnesota, Minneapolis, Minnesota.
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Jann N. Sarkaria
2Mayo Clinic, Rochester, Minnesota.
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  • For correspondence: Sarkaria.jann@mayo.edu
DOI: 10.1158/1535-7163.MCT-17-0600 Published September 2018
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Article Information

Volume 17, Issue 9, pp. 1893-1901

DOI 
https://doi.org/10.1158/1535-7163.MCT-17-0600
PubMed 
29970480

Published By 
American Association for Cancer Research
Print ISSN 
1535-7163
Online ISSN 
1538-8514
History 
  • Received July 18, 2017
  • Revision received October 24, 2017
  • Accepted June 25, 2018
  • Published first July 3, 2018.

Article Versions

  • Previous version (July 3, 2018 - 06:38).
  • Previous version (August 9, 2018 - 07:03).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2018 American Association for Cancer Research.

Author Information

  1. Minjee Kim1,
  2. Daniel J. Ma2,
  3. David Calligaris3,4,
  4. Shuangling Zhang1,
  5. Ryan W. Feathers5,
  6. Rachael A. Vaubel2,
  7. Isabelle Meaux6,
  8. Ann C. Mladek2,
  9. Karen E. Parrish1,
  10. Fang Jin2,
  11. Cedric Barriere6,
  12. Laurent Debussche6,
  13. James Watters6,
  14. Shulan Tian2,
  15. Paul A Decker2,
  16. Jeanette E. Eckel-Passow2,
  17. Gaspar J. Kitange2,
  18. Aaron J. Johnson2,
  19. Ian F. Parney2,
  20. Panos Z. Anastasiadis5,
  21. Nathalie Y.R. Agar3,4,7,
  22. William F. Elmquist1, and
  23. Jann N. Sarkaria2,*
  1. 1University of Minnesota, Minneapolis, Minnesota.
  2. 2Mayo Clinic, Rochester, Minnesota.
  3. 3Brigham and Women's Hospital, Boston, Massachusetts.
  4. 4Harvard Medical School, Boston, Massachusetts.
  5. 5Mayo Clinic, Jacksonville, Florida.
  6. 6Sanofi Oncology, Vitry-sur-Seine, France.
  7. 7Dana Farber Cancer Institute, Boston, Massachusetts.
  1. ↵*Corresponding Author:
    Jann N. Sarkaria, 200 First Street, SW, Rochester, MN 55905. Phone: 507-284-9025; Fax: 507-284-3906; E-mail: Sarkaria.jann{at}mayo.edu
  1. M. Kim and D.J. Ma contributed equally to this article.

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Molecular Cancer Therapeutics: 17 (9)
September 2018
Volume 17, Issue 9
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Efficacy of the MDM2 Inhibitor SAR405838 in Glioblastoma Is Limited by Poor Distribution Across the Blood–Brain Barrier
Minjee Kim, Daniel J. Ma, David Calligaris, Shuangling Zhang, Ryan W. Feathers, Rachael A. Vaubel, Isabelle Meaux, Ann C. Mladek, Karen E. Parrish, Fang Jin, Cedric Barriere, Laurent Debussche, James Watters, Shulan Tian, Paul A Decker, Jeanette E. Eckel-Passow, Gaspar J. Kitange, Aaron J. Johnson, Ian F. Parney, Panos Z. Anastasiadis, Nathalie Y.R. Agar, William F. Elmquist and Jann N. Sarkaria
Mol Cancer Ther September 1 2018 (17) (9) 1893-1901; DOI: 10.1158/1535-7163.MCT-17-0600

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Efficacy of the MDM2 Inhibitor SAR405838 in Glioblastoma Is Limited by Poor Distribution Across the Blood–Brain Barrier
Minjee Kim, Daniel J. Ma, David Calligaris, Shuangling Zhang, Ryan W. Feathers, Rachael A. Vaubel, Isabelle Meaux, Ann C. Mladek, Karen E. Parrish, Fang Jin, Cedric Barriere, Laurent Debussche, James Watters, Shulan Tian, Paul A Decker, Jeanette E. Eckel-Passow, Gaspar J. Kitange, Aaron J. Johnson, Ian F. Parney, Panos Z. Anastasiadis, Nathalie Y.R. Agar, William F. Elmquist and Jann N. Sarkaria
Mol Cancer Ther September 1 2018 (17) (9) 1893-1901; DOI: 10.1158/1535-7163.MCT-17-0600
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