Molecular Cancer Therapeutics: 17 (9)

Highlights

Highlights

Highlights of This Issue

Mol Cancer Ther September 1 2018 17 (9) 1793-1793;

Reviews

Reviews

Strategies to Address Chimeric Antigen Receptor Tonic Signaling

Adam Ajina and John Maher

Mol Cancer Ther September 1 2018 17 (9) 1795-1815; DOI:10.1158/1535-7163.MCT-17-1097
Reviews

Shedding Light on the Dark Cancer Genomes: Long Noncoding RNAs as Novel Biomarkers and Potential Therapeutic Targets for Cancer

Lin Zhang, Dan Peng, Anil K. Sood, Chi V. Dang and Xiaomin Zhong

Mol Cancer Ther September 1 2018 17 (9) 1816-1823; DOI:10.1158/1535-7163.MCT-18-0124
Reviews

We're Not “DON” Yet: Optimal Dosing and Prodrug Delivery of 6-Diazo-5-oxo-L-norleucine

Kathryn M. Lemberg, James J. Vornov, Rana Rais and Barbara S. Slusher

Mol Cancer Ther September 1 2018 17 (9) 1824-1832; DOI:10.1158/1535-7163.MCT-17-1148

Small Molecule Therapeutics

Small Molecule Therapeutics

AKR1C3 Inhibitor KV-37 Exhibits Antineoplastic Effects and Potentiates Enzalutamide in Combination Therapy in Prostate Adenocarcinoma Cells

Kshitij Verma, Nehal Gupta, Tianzhu Zang, Phumvadee Wangtrakluldee, Sanjay K. Srivastava, Trevor M. Penning and Paul C. Trippier

Mol Cancer Ther September 1 2018 17 (9) 1833-1845; DOI:10.1158/1535-7163.MCT-17-1023
Small Molecule Therapeutics

Novel Trifluoromethylated Enobosarm Analogues with Potent Antiandrogenic Activity In Vitro and Tissue Selectivity In Vivo

D. Alwyn Dart, Sahar Kandil, Serena Tommasini-Ghelfi, Gilberto Serrano de Almeida, Charlotte L. Bevan, Wenguo Jiang and Andrew D. Westwell

Mol Cancer Ther September 1 2018 17 (9) 1846-1858; DOI:10.1158/1535-7163.MCT-18-0037
Small Molecule Therapeutics

Repositioning Dopamine D2 Receptor Agonist Bromocriptine to Enhance Docetaxel Chemotherapy and Treat Bone Metastatic Prostate Cancer

Yang Yang, Kenza Mamouni, Xin Li, Yanhua Chen, Sravan Kavuri, Yuhong Du, Haian Fu, Omer Kucuk and Daqing Wu

Mol Cancer Ther September 1 2018 17 (9) 1859-1870; DOI:10.1158/1535-7163.MCT-17-1176
Small Molecule Therapeutics

Arsenic Trioxide and Sorafenib Induce Synthetic Lethality of FLT3-ITD Acute Myeloid Leukemia Cells

Rui Wang, Ying Li, Ping Gong, Janice Gabrilove, Samuel Waxman and Yongkui Jing

Mol Cancer Ther September 1 2018 17 (9) 1871-1880; DOI:10.1158/1535-7163.MCT-17-0298
Small Molecule Therapeutics

A Quinoline-Based DNA Methyltransferase Inhibitor as a Possible Adjuvant in Osteosarcoma Therapy

Maria Cristina Manara, Sergio Valente, Camilla Cristalli, Giordano Nicoletti, Lorena Landuzzi, Clemens Zwergel, Roberta Mazzone, Giulia Stazi, Paola B. Arimondo, Michela Pasello, Clara Guerzoni, Piero Picci, Patrizia Nanni, Pier-Luigi Lollini, Antonello Mai and Katia Scotlandi

Mol Cancer Ther September 1 2018 17 (9) 1881-1892; DOI:10.1158/1535-7163.MCT-17-0818
Small Molecule Therapeutics

Efficacy of the MDM2 Inhibitor SAR405838 in Glioblastoma Is Limited by Poor Distribution Across the Blood–Brain Barrier

Minjee Kim, Daniel J. Ma, David Calligaris, Shuangling Zhang, Ryan W. Feathers, Rachael A. Vaubel, Isabelle Meaux, Ann C. Mladek, Karen E. Parrish, Fang Jin, Cedric Barriere, Laurent Debussche, James Watters, Shulan Tian, Paul A Decker, Jeanette E. Eckel-Passow, Gaspar J. Kitange, Aaron J. Johnson, Ian F. Parney, Panos Z. Anastasiadis, Nathalie Y.R. Agar, William F. Elmquist and Jann N. Sarkaria

Mol Cancer Ther September 1 2018 17 (9) 1893-1901; DOI:10.1158/1535-7163.MCT-17-0600
Small Molecule Therapeutics | AuthorChoice

Therapeutic Targeting of KDM1A/LSD1 in Ewing Sarcoma with SP-2509 Engages the Endoplasmic Reticulum Stress Response

Kathleen I. Pishas, Christina D. Drenberg, Cenny Taslim, Emily R. Theisen, Kirsten M. Johnson, Ranajeet S. Saund, Ioana L. Pop, Brian D. Crompton, Elizabeth R. Lawlor, Franck Tirode, Jaume Mora, Olivier Delattre, Mary C. Beckerle, David F. Callen, Sunil Sharma and Stephen L. Lessnick

Mol Cancer Ther September 1 2018 17 (9) 1902-1916; DOI:10.1158/1535-7163.MCT-18-0373

Large Molecule Therapeutics

Large Molecule Therapeutics | AuthorChoice

STAT3 Cyclic Decoy Demonstrates Robust Antitumor Effects in Non–Small Cell Lung Cancer

Christian Njatcha, Mariya Farooqui, Adam Kornberg, Daniel E. Johnson, Jennifer R. Grandis and Jill M. Siegfried

Mol Cancer Ther September 1 2018 17 (9) 1917-1926; DOI:10.1158/1535-7163.MCT-17-1194
Large Molecule Therapeutics | AuthorChoice

Anti-PSMA/CD3 Bispecific Antibody Delivery and Antitumor Activity Using a Polymeric Depot Formulation

Wilhem Leconet, He Liu, Ming Guo, Sophie Le Lamer-Déchamps, Charlotte Molinier, Sae Kim, Tjasa Vrlinic, Murielle Oster, Fang Liu, Vicente Navarro, Jaspreet S. Batra, Adolfo Lopez Noriega, Sylvestre Grizot and Neil H. Bander

Mol Cancer Ther September 1 2018 17 (9) 1927-1940; DOI:10.1158/1535-7163.MCT-17-1138
Large Molecule Therapeutics

Intratumoral Delivery of an Adenoviral Vector Carrying the SOCS-1 Gene Enhances T-Cell–Mediated Antitumor Immunity By Suppressing PD-L1

Satoshi Nakagawa, Satoshi Serada, Reisa Kakubari, Kosuke Hiramatsu, Takahito Sugase, Shinya Matsuzaki, Satoko Matsuzaki, Yutaka Ueda, Kiyoshi Yoshino, Tomoharu Ohkawara, Minoru Fujimoto, Tadamitsu Kishimoto, Tadashi Kimura and Tetsuji Naka

Mol Cancer Ther September 1 2018 17 (9) 1941-1950; DOI:10.1158/1535-7163.MCT-17-0822
Large Molecule Therapeutics

Recombinant MDA-7/IL24 Suppresses Prostate Cancer Bone Metastasis through Downregulation of the Akt/Mcl-1 Pathway

Anjan K. Pradhan, Praveen Bhoopathi, Sarmistha Talukdar, Xue-Ning Shen, Luni Emdad, Swadesh K. Das, Devanand Sarkar and Paul B. Fisher

Mol Cancer Ther September 1 2018 17 (9) 1951-1960; DOI:10.1158/1535-7163.MCT-17-1002
Large Molecule Therapeutics | AuthorChoice

Leukocyte Differentiation by Histidine-Rich Glycoprotein/Stanniocalcin-2 Complex Regulates Murine Glioma Growth through Modulation of Antitumor Immunity

Francis P. Roche, Ilkka Pietilä, Hiroshi Kaito, Elisabet O. Sjöström, Nadine Sobotzki, Oriol Noguer, Tor Persson Skare, Magnus Essand, Bernd Wollscheid, Michael Welsh and Lena Claesson-Welsh

Mol Cancer Ther September 1 2018 17 (9) 1961-1972; DOI:10.1158/1535-7163.MCT-18-0097

Cancer Biology and Translational Studies

Cancer Biology and Translational Studies

KDM6B Counteracts EZH2-Mediated Suppression of IGFBP5 to Confer Resistance to PI3K/AKT Inhibitor Treatment in Breast Cancer

Wenyu Wang, Keng Gat Lim, Min Feng, Yi Bao, Puay Leng Lee, Yu Cai, Yufeng Chen, Hao Zhang, Diego Marzese, Dave S.B. Hoon and Qiang Yu

Mol Cancer Ther September 1 2018 17 (9) 1973-1983; DOI:10.1158/1535-7163.MCT-17-0802
Cancer Biology and Translational Studies

Identification of FDA-Approved Oncology Drugs with Selective Potency in High-Risk Childhood Ependymoma

Andrew M. Donson, Vladimir Amani, Elliot A. Warner, Andrea M. Griesinger, Davis A. Witt, Jean M. Mulcahy Levy, Lindsey M. Hoffman, Todd C. Hankinson, Michael H. Handler, Rajeev Vibhakar, Kathleen Dorris and Nicholas K. Foreman

Mol Cancer Ther September 1 2018 17 (9) 1984-1994; DOI:10.1158/1535-7163.MCT-17-1185
Cancer Biology and Translational Studies

Nuclear PTEN Localization Contributes to DNA Damage Response in Endometrial Adenocarcinoma and Could Have a Diagnostic Benefit for Therapeutic Management of the Disease

Ananda Mukherjee, Amanda L. Patterson, Jitu W. George, Tyler J. Carpenter, Zachary B. Madaj, Galen Hostetter, John I. Risinger and Jose M. Teixeira

Mol Cancer Ther September 1 2018 17 (9) 1995-2003; DOI:10.1158/1535-7163.MCT-17-1255
Cancer Biology and Translational Studies

The Role of Pyruvate Dehydrogenase Kinase-4 (PDK4) in Bladder Cancer and Chemoresistance

Benjamin L. Woolbright, Dharamainder Choudhary, Andrew Mikhalyuk, Cassandra Trammel, Sambantham Shanmugam, Erika Abbott, Carol C. Pilbeam and John A. Taylor III

Mol Cancer Ther September 1 2018 17 (9) 2004-2012; DOI:10.1158/1535-7163.MCT-18-0063
Cancer Biology and Translational Studies | AuthorChoice

Induction of Thioredoxin-Interacting Protein by a Histone Deacetylase Inhibitor, Entinostat, Is Associated with DNA Damage and Apoptosis in Esophageal Adenocarcinoma

Paul L. Feingold, Deborah R. Surman, Kate Brown, Yuan Xu, Lucas A. McDuffie, Vivek Shukla, Emily S. Reardon, Daniel R. Crooks, Jane B. Trepel, Sunmin Lee, Min-Jung Lee, Shaojian Gao, Sichuan Xi, Kaitlin C. McLoughlin, Laurence P. Diggs, David G. Beer, Derek J. Nancarrow, Leonard M. Neckers, Jeremy L. Davis, Chuong D. Hoang, Jonathan M. Hernandez, David S. Schrump and R. Taylor Ripley

Mol Cancer Ther September 1 2018 17 (9) 2013-2023; DOI:10.1158/1535-7163.MCT-17-1240
Cancer Biology and Translational Studies | AuthorChoice

Dual Targeting of ERBB2/ERBB3 for the Treatment of SLC3A2-NRG1–Mediated Lung Cancer

Dong Hoon Shin, Jeong Yeon Jo and Ji-Youn Han

Mol Cancer Ther September 1 2018 17 (9) 2024-2033; DOI:10.1158/1535-7163.MCT-17-1178
Cancer Biology and Translational Studies

Targeting Notch1 and IKKα Enhanced NF-κB Activation in CD133⁺ Skin Cancer Stem Cells

Xin Xin Quan, Nga Voong Hawk, Weiping Chen, Jamie Coupar, Steven K. Lee, David W. Petersen, Paul S. Meltzer, Andrew Montemarano, Martin Braun, Zhong Chen and Carter Van Waes

Mol Cancer Ther September 1 2018 17 (9) 2034-2048; DOI:10.1158/1535-7163.MCT-17-0421
Cancer Biology and Translational Studies

Role of EphB3 Receptor in Mediating Head and Neck Tumor Growth, Cell Migration, and Response to PI3K Inhibitor

Shilpa Bhatia, Anastacia Griego, Shelby Lennon, Ayman Oweida, Jaspreet Sharma, Christina Rohmer, Nomin Uyanga, Sanjana Bukkapatnam, Benjamin Van Court, David Raben, Christian Young, Lynn Heasley and Sana D. Karam

Mol Cancer Ther September 1 2018 17 (9) 2049-2059; DOI:10.1158/1535-7163.MCT-17-1163

Companion Diagnostic, Pharmacogenomic, and Cancer Biomarkers

Companion Diagnostic, Pharmacogenomic, and Cancer Biomarkers

Drug-Sensitivity Screening and Genomic Characterization of 45 HPV-Negative Head and Neck Carcinoma Cell Lines for Novel Biomarkers of Drug Efficacy

Tatiana Lepikhova, Piia-Riitta Karhemo, Riku Louhimo, Bhagwan Yadav, Astrid Murumägi, Evgeny Kulesskiy, Mikko Kivento, Harri Sihto, Reidar Grénman, Stina M. Syrjänen, Olli Kallioniemi, Tero Aittokallio, Krister Wennerberg, Heikki Joensuu and Outi Monni

Mol Cancer Ther September 1 2018 17 (9) 2060-2071; DOI:10.1158/1535-7163.MCT-17-0733

Retractions

Retractions | Free Article

Retraction: γ-Tocotrienol Promotes TRAIL-Induced Apoptosis through Reactive Oxygen Species/Extracellular Signal-Regulated Kinase/p53–Mediated Upregulation of Death Receptors

Mol Cancer Ther September 1 2018 17 (9) 2072-2072; DOI:10.1158/1535-7163.MCT-18-0869
Retractions | Free Article

Retraction: Garcinol Potentiates TRAIL-Induced Apoptosis through Modulation of Death Receptors and Antiapoptotic Proteins

Mol Cancer Ther September 1 2018 17 (9) 2073-2073; DOI:10.1158/1535-7163.MCT-18-0870
Retractions | Free Article

Retraction: Coronarin D, a Labdane Diterpene, Inhibits both Constitutive and Inducible Nuclear Factor-κB Pathway Activation, Leading to Potentiation of Apoptosis, Inhibition of Invasion, and Suppression of Osteoclastogenesis

Mol Cancer Ther September 1 2018 17 (9) 2074-2074; DOI:10.1158/1535-7163.MCT-18-0871
Retractions | Free Article

Retraction: Potentiation of Paclitaxel Activity by the HSP90 Inhibitor 17-allylamino-17-demethoxygeldanamycin in Human Ovarian Carcinoma Cell Lines with High Levels of Activated AKT

Mol Cancer Ther September 1 2018 17 (9) 2075-2075; DOI:10.1158/1535-7163.MCT-18-0595

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