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Molecular Cancer Therapeutics
Molecular Cancer Therapeutics
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About the Cover

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ABOUT THE COVER
A Lewis lung carcinoma xenograft tumor section was co-stained with the endothelial marker endomucin, and the proliferation marker Ki-67. These rapidly growing tumors are characterized by high endothelial and tumor cell proliferation in vascular hotspots. In this study, loss of the EYA3 tyrosine phosphatase in either host endothelial cells or tumor cells attenuated tumor growth. Loss of endothelial EYA3 reduced tumor angiogenesis while loss of tumor cell EYA3 reduced cell proliferation and survival. Key – Green: endomucin-positive endothelial cells; red: Ki-67 positive proliferating cells; blue: DAPI-stained nuclei.

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Molecular Cancer Therapeutics: 17 (8)
August 2018
Volume 17, Issue 8
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Issue Highlights

  • Orally Bioavailable and Blood–Brain Barrier-Penetrating ATM Inhibitor (AZ32) Radiosensitizes Intracranial Gliomas in Mice
  • TAS6417, A Novel EGFR Inhibitor Targeting Exon 20 Insertion Mutations
  • The Protein Tyrosine Phosphatase Activity of Eyes Absent Contributes to Tumor Angiogenesis and Tumor Growth
  • The ATR Inhibitor AZD6738 Synergizes with Gemcitabine In Vitro and In Vivo to Induce Pancreatic Ductal Adenocarcinoma Regression
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Copyright © 2021 by the American Association for Cancer Research.

Molecular Cancer Therapeutics
eISSN: 1538-8514
ISSN: 1535-7163

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