Mechanistic Modeling of Antibody–Drug Conjugate Internalization at the Cellular Level Reveals Inefficient Processing Steps

Kenneth R. Durbin; Colin Phipps; Xiaoli Liao

doi:10.1158/1535-7163.MCT-17-0672

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Mechanistic Modeling of Antibody–Drug Conjugate Internalization at the Cellular Level Reveals Inefficient Processing Steps

Kenneth R. Durbin, Colin Phipps and Xiaoli Liao

Kenneth R. Durbin

1Department of Drug Metabolism and Pharmacokinetics, AbbVie, Inc., North Chicago, Illinois.

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For correspondence: kenneth.durbin@abbvie.com

Colin Phipps

1Department of Drug Metabolism and Pharmacokinetics, AbbVie, Inc., North Chicago, Illinois.

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Xiaoli Liao

2Process R&D Department, AbbVie, Inc., North Chicago, Illinois.

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DOI: 10.1158/1535-7163.MCT-17-0672 Published June 2018

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Article Information

Volume 17, Issue 6, pp. 1341-1351

DOI

https://doi.org/10.1158/1535-7163.MCT-17-0672

PubMed

29592884

Published By

American Association for Cancer Research

Print ISSN

1535-7163

Online ISSN

1538-8514

History

Received July 20, 2017
Revision received October 30, 2017
Accepted March 19, 2018
Published first March 28, 2018.

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Previous version (March 28, 2018 - 07:55).
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Author Information

Kenneth R. Durbin1,*,
Colin Phipps1, and
Xiaoli Liao2

¹Department of Drug Metabolism and Pharmacokinetics, AbbVie, Inc., North Chicago, Illinois.
²Process R&D Department, AbbVie, Inc., North Chicago, Illinois.

↵*Corresponding Author:
Kenneth R. Durbin, AbbVie, Inc., North Chicago, IL 60064. Phone: 847-938-4923; E-mail: kenneth.durbin{at}abbvie.com

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June 2018
Volume 17, Issue 6

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Mechanistic Modeling of Antibody–Drug Conjugate Internalization at the Cellular Level Reveals Inefficient Processing Steps