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Models and Technologies

Mechanistic Modeling of Antibody–Drug Conjugate Internalization at the Cellular Level Reveals Inefficient Processing Steps

Kenneth R. Durbin, Colin Phipps and Xiaoli Liao
Kenneth R. Durbin
1Department of Drug Metabolism and Pharmacokinetics, AbbVie, Inc., North Chicago, Illinois.
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  • For correspondence: kenneth.durbin@abbvie.com
Colin Phipps
1Department of Drug Metabolism and Pharmacokinetics, AbbVie, Inc., North Chicago, Illinois.
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Xiaoli Liao
2Process R&D Department, AbbVie, Inc., North Chicago, Illinois.
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DOI: 10.1158/1535-7163.MCT-17-0672 Published June 2018
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Article Information

Volume 17, Issue 6, pp. 1341-1351

DOI 
https://doi.org/10.1158/1535-7163.MCT-17-0672
PubMed 
29592884

Published By 
American Association for Cancer Research
Print ISSN 
1535-7163
Online ISSN 
1538-8514
History 
  • Received July 20, 2017
  • Revision received October 30, 2017
  • Accepted March 19, 2018
  • Published first March 28, 2018.

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  • Previous version (March 28, 2018 - 07:55).
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©2018 American Association for Cancer Research.

Author Information

  1. Kenneth R. Durbin1,*,
  2. Colin Phipps1, and
  3. Xiaoli Liao2
  1. 1Department of Drug Metabolism and Pharmacokinetics, AbbVie, Inc., North Chicago, Illinois.
  2. 2Process R&D Department, AbbVie, Inc., North Chicago, Illinois.
  1. ↵*Corresponding Author:
    Kenneth R. Durbin, AbbVie, Inc., North Chicago, IL 60064. Phone: 847-938-4923; E-mail: kenneth.durbin{at}abbvie.com
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Molecular Cancer Therapeutics: 17 (6)
June 2018
Volume 17, Issue 6
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Mechanistic Modeling of Antibody–Drug Conjugate Internalization at the Cellular Level Reveals Inefficient Processing Steps
Kenneth R. Durbin, Colin Phipps and Xiaoli Liao
Mol Cancer Ther June 1 2018 (17) (6) 1341-1351; DOI: 10.1158/1535-7163.MCT-17-0672

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Mechanistic Modeling of Antibody–Drug Conjugate Internalization at the Cellular Level Reveals Inefficient Processing Steps
Kenneth R. Durbin, Colin Phipps and Xiaoli Liao
Mol Cancer Ther June 1 2018 (17) (6) 1341-1351; DOI: 10.1158/1535-7163.MCT-17-0672
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Molecular Cancer Therapeutics
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