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Molecular Cancer Therapeutics
Molecular Cancer Therapeutics
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About the Cover

Cover image

Cover image expansion

ABOUT THE COVER
Cover image adapted from Figure 3C, published in Sagnella et al., beginning on page 1012. In the original figure, fluorescence imaging microscopy (FLIM) was employed on three dimensional (3D)–spheroid cultures treated with doxorubicin to detect drug life–time in cells. The image shows the accumulated intensity of fluorescence in the sample overlayed with the lifetime segmented pixel groups in the phasor plot. Using the phasor analysis, the lifetime at each pixel of the image is converted into the frequency domain, with fluorescence decays from each pixel represented as sine and cosine Fourier transforms and plotted in a polar plot. The phasor plot has been color coded to distinguish different lifetime populations which also correspond to different cellular environments and compartments. In the image the shorter lifetime component is highlighted in grey and corresponds to nuclear localization of doxorubicin.

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Molecular Cancer Therapeutics: 17 (5)
May 2018
Volume 17, Issue 5
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Issue Highlights

  • Preclinical Activity of Abemaciclib Alone or in Combination with Antimitotic and Targeted Therapies in Breast Cancer
  • Antitumor Activity of Osimertinib, an Irreversible Mutant-Selective EGFR Tyrosine Kinase Inhibitor, in NSCLC Harboring EGFR Exon 20 Insertions
  • Targeted Doxorubicin-Loaded Bacterially Derived Nano-Cells for the Treatment of Neuroblastoma
  • In Vitro and In Vivo Activity of IMGN853, an Antibody–Drug Conjugate Targeting Folate Receptor Alpha Linked to DM4, in Biologically Aggressive Endometrial Cancers
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Molecular Cancer Therapeutics
eISSN: 1538-8514
ISSN: 1535-7163

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