Molecular Cancer Therapeutics: 17 (5)

Highlights

Highlights

Highlights of This Issue

Mol Cancer Ther May 1 2018 17 (5) 883-883;

Small Molecule Therapeutics

Small Molecule Therapeutics

Antitumor Activity of Osimertinib, an Irreversible Mutant-Selective EGFR Tyrosine Kinase Inhibitor, in NSCLC Harboring EGFR Exon 20 Insertions

Nicolas Floc'h, Matthew J. Martin, Jonathan W. Riess, Jonathan P. Orme, Anna D. Staniszewska, Ludovic Ménard, Maria Emanuela Cuomo, Daniel J. O'Neill, Richard A. Ward, M. Raymond V. Finlay, Darren McKerrecher, Mingshan Cheng, Daniel P. Vang, Rebekah A. Burich, James G. Keck, David R. Gandara, Philip C. Mack and Darren A.E. Cross

Mol Cancer Ther May 1 2018 17 (5) 885-896; DOI:10.1158/1535-7163.MCT-17-0758
Small Molecule Therapeutics | AuthorChoice

Preclinical Activity of Abemaciclib Alone or in Combination with Antimitotic and Targeted Therapies in Breast Cancer

Neil O'Brien, Dylan Conklin, Richard Beckmann, Tong Luo, Kevin Chau, Josh Thomas, Ann Mc Nulty, Christophe Marchal, Ondrej Kalous, Erika von Euw, Sara Hurvitz, Colleen Mockbee and Dennis J. Slamon

Mol Cancer Ther May 1 2018 17 (5) 897-907; DOI:10.1158/1535-7163.MCT-17-0290
Small Molecule Therapeutics | AuthorChoice

Combined Inhibition of mTOR and CDK4/6 Is Required for Optimal Blockade of E2F Function and Long-term Growth Inhibition in Estrogen Receptor–positive Breast Cancer

Chrysiis Michaloglou, Claire Crafter, Rasmus Siersbaek, Oona Delpuech, Jon O. Curwen, Larissa S. Carnevalli, Anna D. Staniszewska, Urszula M. Polanska, Azadeh Cheraghchi-Bashi, Mandy Lawson, Igor Chernukhin, Robert McEwen, Jason S. Carroll and Sabina C. Cosulich

Mol Cancer Ther May 1 2018 17 (5) 908-920; DOI:10.1158/1535-7163.MCT-17-0537
Small Molecule Therapeutics

Trastuzumab-Resistant HER2⁺ Breast Cancer Cells Retain Sensitivity to Poly (ADP-Ribose) Polymerase (PARP) Inhibition

Monica E. Wielgos, Zhuo Zhang, Rajani Rajbhandari, Tiffiny S. Cooper, Ling Zeng, Andres Forero, Francisco J. Esteva, C. Kent Osborne, Rachel Schiff, Albert F. LoBuglio, Susan E. Nozell and Eddy S. Yang

Mol Cancer Ther May 1 2018 17 (5) 921-930; DOI:10.1158/1535-7163.MCT-17-0302
Small Molecule Therapeutics

Impact of the Anticancer Drug NT157 on Tyrosine Kinase Signaling Networks

Shih-Ping Su, Efrat Flashner-Abramson, Shoshana Klein, Mor Gal, Rachel S. Lee, Jianmin Wu, Alexander Levitzki and Roger J. Daly

Mol Cancer Ther May 1 2018 17 (5) 931-942; DOI:10.1158/1535-7163.MCT-17-0377
Small Molecule Therapeutics

Cholesterol Depletion by TASIN-1 Induces Apoptotic Cell Death through the ER Stress/ROS/JNK Signaling in Colon Cancer Cells

Lu Zhang, Sang Bum Kim, Krishna Luitel and Jerry W. Shay

Mol Cancer Ther May 1 2018 17 (5) 943-951; DOI:10.1158/1535-7163.MCT-17-0887
Small Molecule Therapeutics

Nigericin Exerts Anticancer Effects on Human Colorectal Cancer Cells by Inhibiting Wnt/β-catenin Signaling Pathway

Fei Liu, Wei Li, Shangbo Hua, Ye Han, Zhihua Xu, Daiwei Wan, Yilin Wang, Weichang Chen, Yuting Kuang, Jianming Shi and Qiaoming Zhi

Mol Cancer Ther May 1 2018 17 (5) 952-965; DOI:10.1158/1535-7163.MCT-17-0906
Small Molecule Therapeutics

A Tricin Derivative from Deschampsia antarctica Desv. Inhibits Colorectal Carcinoma Growth and Liver Metastasis through the Induction of a Specific Immune Response

Mariana Malvicini, Ana Gutierrez-Moraga, Marcelo M. Rodriguez, Sofia Gomez-Bustillo, Lorena Salazar, Carlos Sunkel, Leonor Nozal, Antonio Salgado, Manuel Hidalgo, Pedro P. Lopez-Casas, Jose Luis Novella, Juan Jose Vaquero, Julio Alvarez-Builla, Adda Mora, Manuel Gidekel and Guillermo Mazzolini

Mol Cancer Ther May 1 2018 17 (5) 966-976; DOI:10.1158/1535-7163.MCT-17-0193
Small Molecule Therapeutics

A miR-29b Byproduct Sequence Exhibits Potent Tumor-Suppressive Activities via Inhibition of NF-κB Signaling in KRAS-Mutant Colon Cancer Cells

Akira Inoue, Tsunekazu Mizushima, Xin Wu, Daisuke Okuzaki, Nanami Kambara, Sho Ishikawa, Jiaqi Wang, Yamin Qian, Haruka Hirose, Yuhki Yokoyama, Ryo Ikeshima, Masayuki Hiraki, Norikatsu Miyoshi, Hidekazu Takahashi, Naotsugu Haraguchi, Taishi Hata, Chu Matsuda, Yuichiro Doki, Masaki Mori and Hirofumi Yamamoto

Mol Cancer Ther May 1 2018 17 (5) 977-987; DOI:10.1158/1535-7163.MCT-17-0850
Small Molecule Therapeutics

Targeting Polo-like Kinase 1 by a Novel Pyrrole-Imidazole Polyamide–Hoechst Conjugate Suppresses Tumor Growth In Vivo

Ke Liu, Lijing Fang, Haiyan Sun, Zhengyin Pan, Jianchao Zhang, Juntao Chen, Ximing Shao, Wei Wang, Yuanyan Tan, Zhihao Ding, Lijiao Ao, Chunlei Wu, Xiaoqi Liu, Huashun Li, Rui Wang, Wu Su and Hongchang Li

Mol Cancer Ther May 1 2018 17 (5) 988-1002; DOI:10.1158/1535-7163.MCT-17-0747

Large Molecule Therapeutics

Large Molecule Therapeutics

In Vitro and In Vivo Activity of IMGN853, an Antibody–Drug Conjugate Targeting Folate Receptor Alpha Linked to DM4, in Biologically Aggressive Endometrial Cancers

Gary Altwerger, Elena Bonazzoli, Stefania Bellone, Tomomi Egawa-Takata, Gulden Menderes, Francesca Pettinella, Anna Bianchi, Francesco Riccio, Jacqueline Feinberg, Luca Zammataro, Chanhee Han, Ghanshyam Yadav, Katherine Dugan, Ashley Morneault, Jose F. Ponte, Natalia Buza, Pei Hui, Serena Wong, Babak Litkouhi, Elena Ratner, Dan-Arin Silasi, Gloria S. Huang, Masoud Azodi, Peter E. Schwartz and Alessandro D. Santin

Mol Cancer Ther May 1 2018 17 (5) 1003-1011; DOI:10.1158/1535-7163.MCT-17-0930
Large Molecule Therapeutics

Targeted Doxorubicin-Loaded Bacterially Derived Nano-Cells for the Treatment of Neuroblastoma

Sharon M. Sagnella, Jennifer Trieu, Himanshu Brahmbhatt, Jennifer A. MacDiarmid, Alex MacMillan, Renee M. Whan, Christopher M. Fife, Joshua A. McCarroll, Andrew J. Gifford, David S. Ziegler and Maria Kavallaris

Mol Cancer Ther May 1 2018 17 (5) 1012-1023; DOI:10.1158/1535-7163.MCT-17-0738
Large Molecule Therapeutics | AuthorChoice

Potent Immune Modulation by MEDI6383, an Engineered Human OX40 Ligand IgG4P Fc Fusion Protein

Michael D. Oberst, Catherine Augé, Chad Morris, Stacy Kentner, Kathy Mulgrew, Kelly McGlinchey, James Hair, Shino Hanabuchi, Qun Du, Melissa Damschroder, Hui Feng, Steven Eck, Nicholas Buss, Lolke de Haan, Andrew J. Pierce, Haesun Park, Andrew Sylwester, Michael K. Axthelm, Louis Picker, Nicholas P. Morris, Andrew Weinberg and Scott A. Hammond

Mol Cancer Ther May 1 2018 17 (5) 1024-1038; DOI:10.1158/1535-7163.MCT-17-0200
Large Molecule Therapeutics | AuthorChoice

ABT-165, a Dual Variable Domain Immunoglobulin (DVD-Ig) Targeting DLL4 and VEGF, Demonstrates Superior Efficacy and Favorable Safety Profiles in Preclinical Models

Yingchun Li, Jonathan A. Hickson, Dominic J. Ambrosi, Deanna L. Haasch, Kelly D. Foster-Duke, Lucia J. Eaton, Enrico L. DiGiammarino, Sanjay C. Panchal, Fang Jiang, Sarah R. Mudd, Catherine Zhang, Surekha S. Akella, Wenqing Gao, Sherry L. Ralston, Louie Naumovski, Jijie Gu and Susan E. Morgan-Lappe

Mol Cancer Ther May 1 2018 17 (5) 1039-1050; DOI:10.1158/1535-7163.MCT-17-0800

Cancer Biology and Translational Studies

Cancer Biology and Translational Studies

Small Molecule–Mediated Activation of RAS Elicits Biphasic Modulation of Phospho-ERK Levels that Are Regulated through Negative Feedback on SOS1

Jennifer E. Howes, Denis T. Akan, Michael C. Burns, Olivia W. Rossanese, Alex G. Waterson and Stephen W. Fesik

Mol Cancer Ther May 1 2018 17 (5) 1051-1060; DOI:10.1158/1535-7163.MCT-17-0666
Cancer Biology and Translational Studies | AuthorChoice

MicroRNA-203 Inhibits Long Noncoding RNA HOTAIR and Regulates Tumorigenesis through Epithelial-to-mesenchymal Transition Pathway in Renal Cell Carcinoma

Pritha Dasgupta, Priyanka Kulkarni, Shahana Majid, Varahram Shahryari, Yutaka Hashimoto, Nadeem S. Bhat, Marisa Shiina, Guoren Deng, Sharanjot Saini, Z. Laura Tabatabai, Soichiro Yamamura, Yuichiro Tanaka and Rajvir Dahiya

Mol Cancer Ther May 1 2018 17 (5) 1061-1069; DOI:10.1158/1535-7163.MCT-17-0925
Cancer Biology and Translational Studies

Inhibition of the Histone H3K27 Demethylase UTX Enhances Tumor Cell Radiosensitivity

Barbara H. Rath, Isabella Waung, Kevin Camphausen and Philip J. Tofilon

Mol Cancer Ther May 1 2018 17 (5) 1070-1078; DOI:10.1158/1535-7163.MCT-17-1053
Cancer Biology and Translational Studies

EGF Receptor and mTORC1 Are Novel Therapeutic Targets in Nonseminomatous Germ Cell Tumors

Kenneth S. Chen, Nicholas J. Fustino, Abhay A. Shukla, Emily K. Stroup, Albert Budhipramono, Christina Ateek, Sarai H. Stuart, Kiyoshi Yamaguchi, Payal Kapur, A. Lindsay Frazier, Lawrence Lum, Leendert H.J. Looijenga, Theodore W. Laetsch, Dinesh Rakheja and James F. Amatruda

Mol Cancer Ther May 1 2018 17 (5) 1079-1089; DOI:10.1158/1535-7163.MCT-17-0137
Cancer Biology and Translational Studies

p110α Inhibition Overcomes Stromal Cell–Mediated Ibrutinib Resistance in Mantle Cell Lymphoma

Jiyu Guan, Dan Huang, Konstantin Yakimchuk and Sam Okret

Mol Cancer Ther May 1 2018 17 (5) 1090-1100; DOI:10.1158/1535-7163.MCT-17-0784
Cancer Biology and Translational Studies

Targeting PRPK Function Blocks Colon Cancer Metastasis

Tatyana Zykova, Feng Zhu, Lei Wang, Haitao Li, Do Young Lim, Ke Yao, Eunmiri Roh, Sang-Pil Yoon, Hong-Gyum Kim, Ki Beom Bae, Weihong Wen, Seung Ho Shin, Janos Nadas, Yan Li, Weiya Ma, Ann M. Bode and Zigang Dong

Mol Cancer Ther May 1 2018 17 (5) 1101-1113; DOI:10.1158/1535-7163.MCT-17-0628

Companion Diagnostic, Pharmacogenomic, and Cancer Biomarkers

Companion Diagnostic, Pharmacogenomic, and Cancer Biomarkers

Analysis of Tissue and Circulating Tumor DNA by Next-Generation Sequencing of Hepatocellular Carcinoma: Implications for Targeted Therapeutics

Sadakatsu Ikeda, Jordan S. Lim and Razelle Kurzrock

Mol Cancer Ther May 1 2018 17 (5) 1114-1122; DOI:10.1158/1535-7163.MCT-17-0604
Companion Diagnostic, Pharmacogenomic, and Cancer Biomarkers

Correlation of Somatic Genomic Alterations Between Tissue Genomics and ctDNA Employing Next-Generation Sequencing: Analysis of Lung and Gastrointestinal Cancers

Omer M. Toor, Zaheer Ahmed, Waled Bahaj, Urooge Boda, Lee S. Cummings, Megan E. McNally, Kevin F. Kennedy, Timothy J. Pluard, Arif Hussain, Janakiraman Subramanian and Ashiq Masood

Mol Cancer Ther May 1 2018 17 (5) 1123-1132; DOI:10.1158/1535-7163.MCT-17-1015

Models and Technologies

Models and Technologies

Anti-HER2 scFv-Directed Extracellular Vesicle-Mediated mRNA-Based Gene Delivery Inhibits Growth of HER2-Positive Human Breast Tumor Xenografts by Prodrug Activation

Jing-Hung Wang, Alexis V. Forterre, Jinjing Zhao, Daniel O. Frimannsson, Alain Delcayre, Travis J. Antes, Bradley Efron, Stefanie S. Jeffrey, Mark D. Pegram and A.C. Matin

Mol Cancer Ther May 1 2018 17 (5) 1133-1142; DOI:10.1158/1535-7163.MCT-17-0827

Correction

Correction | Free Article

Correction: PRIMA-1Met/APR-246 Displays High Antitumor Activity in Multiple Myeloma by Induction of p73 and Noxa

Mol Cancer Ther May 1 2018 17 (5) 1143-1143; DOI:10.1158/1535-7163.MCT-18-0096

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Highlights

Small Molecule Therapeutics

Large Molecule Therapeutics

Cancer Biology and Translational Studies

Companion Diagnostic, Pharmacogenomic, and Cancer Biomarkers

Models and Technologies

Correction

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