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Molecular Cancer Therapeutics
Molecular Cancer Therapeutics
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Table of Contents

Highlights

  • Highlights
    Highlights of This Issue
    Mol Cancer Ther May 1 2018 17 (5) 883-883;

Small Molecule Therapeutics

  • Small Molecule Therapeutics
    Antitumor Activity of Osimertinib, an Irreversible Mutant-Selective EGFR Tyrosine Kinase Inhibitor, in NSCLC Harboring EGFR Exon 20 Insertions
    Nicolas Floc'h, Matthew J. Martin, Jonathan W. Riess, Jonathan P. Orme, Anna D. Staniszewska, Ludovic Ménard, Maria Emanuela Cuomo, Daniel J. O'Neill, Richard A. Ward, M. Raymond V. Finlay, Darren McKerrecher, Mingshan Cheng, Daniel P. Vang, Rebekah A. Burich, James G. Keck, David R. Gandara, Philip C. Mack and Darren A.E. Cross
    Mol Cancer Ther May 1 2018 17 (5) 885-896; DOI:10.1158/1535-7163.MCT-17-0758

  • Small Molecule Therapeutics | AuthorChoice
    Preclinical Activity of Abemaciclib Alone or in Combination with Antimitotic and Targeted Therapies in Breast Cancer
    Neil O'Brien, Dylan Conklin, Richard Beckmann, Tong Luo, Kevin Chau, Josh Thomas, Ann Mc Nulty, Christophe Marchal, Ondrej Kalous, Erika von Euw, Sara Hurvitz, Colleen Mockbee and Dennis J. Slamon
    Mol Cancer Ther May 1 2018 17 (5) 897-907; DOI:10.1158/1535-7163.MCT-17-0290

  • Small Molecule Therapeutics | AuthorChoice
    Combined Inhibition of mTOR and CDK4/6 Is Required for Optimal Blockade of E2F Function and Long-term Growth Inhibition in Estrogen Receptor–positive Breast Cancer
    Chrysiis Michaloglou, Claire Crafter, Rasmus Siersbaek, Oona Delpuech, Jon O. Curwen, Larissa S. Carnevalli, Anna D. Staniszewska, Urszula M. Polanska, Azadeh Cheraghchi-Bashi, Mandy Lawson, Igor Chernukhin, Robert McEwen, Jason S. Carroll and Sabina C. Cosulich
    Mol Cancer Ther May 1 2018 17 (5) 908-920; DOI:10.1158/1535-7163.MCT-17-0537

  • Small Molecule Therapeutics
    Trastuzumab-Resistant HER2+ Breast Cancer Cells Retain Sensitivity to Poly (ADP-Ribose) Polymerase (PARP) Inhibition
    Monica E. Wielgos, Zhuo Zhang, Rajani Rajbhandari, Tiffiny S. Cooper, Ling Zeng, Andres Forero, Francisco J. Esteva, C. Kent Osborne, Rachel Schiff, Albert F. LoBuglio, Susan E. Nozell and Eddy S. Yang
    Mol Cancer Ther May 1 2018 17 (5) 921-930; DOI:10.1158/1535-7163.MCT-17-0302

  • Small Molecule Therapeutics
    Impact of the Anticancer Drug NT157 on Tyrosine Kinase Signaling Networks
    Shih-Ping Su, Efrat Flashner-Abramson, Shoshana Klein, Mor Gal, Rachel S. Lee, Jianmin Wu, Alexander Levitzki and Roger J. Daly
    Mol Cancer Ther May 1 2018 17 (5) 931-942; DOI:10.1158/1535-7163.MCT-17-0377

  • Small Molecule Therapeutics
    Cholesterol Depletion by TASIN-1 Induces Apoptotic Cell Death through the ER Stress/ROS/JNK Signaling in Colon Cancer Cells
    Lu Zhang, Sang Bum Kim, Krishna Luitel and Jerry W. Shay
    Mol Cancer Ther May 1 2018 17 (5) 943-951; DOI:10.1158/1535-7163.MCT-17-0887

  • Small Molecule Therapeutics
    Nigericin Exerts Anticancer Effects on Human Colorectal Cancer Cells by Inhibiting Wnt/β-catenin Signaling Pathway
    Fei Liu, Wei Li, Shangbo Hua, Ye Han, Zhihua Xu, Daiwei Wan, Yilin Wang, Weichang Chen, Yuting Kuang, Jianming Shi and Qiaoming Zhi
    Mol Cancer Ther May 1 2018 17 (5) 952-965; DOI:10.1158/1535-7163.MCT-17-0906

  • Small Molecule Therapeutics
    A Tricin Derivative from Deschampsia antarctica Desv. Inhibits Colorectal Carcinoma Growth and Liver Metastasis through the Induction of a Specific Immune Response
    Mariana Malvicini, Ana Gutierrez-Moraga, Marcelo M. Rodriguez, Sofia Gomez-Bustillo, Lorena Salazar, Carlos Sunkel, Leonor Nozal, Antonio Salgado, Manuel Hidalgo, Pedro P. Lopez-Casas, Jose Luis Novella, Juan Jose Vaquero, Julio Alvarez-Builla, Adda Mora, Manuel Gidekel and Guillermo Mazzolini
    Mol Cancer Ther May 1 2018 17 (5) 966-976; DOI:10.1158/1535-7163.MCT-17-0193

  • Small Molecule Therapeutics
    A miR-29b Byproduct Sequence Exhibits Potent Tumor-Suppressive Activities via Inhibition of NF-κB Signaling in KRAS-Mutant Colon Cancer Cells
    Akira Inoue, Tsunekazu Mizushima, Xin Wu, Daisuke Okuzaki, Nanami Kambara, Sho Ishikawa, Jiaqi Wang, Yamin Qian, Haruka Hirose, Yuhki Yokoyama, Ryo Ikeshima, Masayuki Hiraki, Norikatsu Miyoshi, Hidekazu Takahashi, Naotsugu Haraguchi, Taishi Hata, Chu Matsuda, Yuichiro Doki, Masaki Mori and Hirofumi Yamamoto
    Mol Cancer Ther May 1 2018 17 (5) 977-987; DOI:10.1158/1535-7163.MCT-17-0850

  • Small Molecule Therapeutics
    Targeting Polo-like Kinase 1 by a Novel Pyrrole-Imidazole Polyamide–Hoechst Conjugate Suppresses Tumor Growth In Vivo
    Ke Liu, Lijing Fang, Haiyan Sun, Zhengyin Pan, Jianchao Zhang, Juntao Chen, Ximing Shao, Wei Wang, Yuanyan Tan, Zhihao Ding, Lijiao Ao, Chunlei Wu, Xiaoqi Liu, Huashun Li, Rui Wang, Wu Su and Hongchang Li
    Mol Cancer Ther May 1 2018 17 (5) 988-1002; DOI:10.1158/1535-7163.MCT-17-0747

Large Molecule Therapeutics

  • Large Molecule Therapeutics
    In Vitro and In Vivo Activity of IMGN853, an Antibody–Drug Conjugate Targeting Folate Receptor Alpha Linked to DM4, in Biologically Aggressive Endometrial Cancers
    Gary Altwerger, Elena Bonazzoli, Stefania Bellone, Tomomi Egawa-Takata, Gulden Menderes, Francesca Pettinella, Anna Bianchi, Francesco Riccio, Jacqueline Feinberg, Luca Zammataro, Chanhee Han, Ghanshyam Yadav, Katherine Dugan, Ashley Morneault, Jose F. Ponte, Natalia Buza, Pei Hui, Serena Wong, Babak Litkouhi, Elena Ratner, Dan-Arin Silasi, Gloria S. Huang, Masoud Azodi, Peter E. Schwartz and Alessandro D. Santin
    Mol Cancer Ther May 1 2018 17 (5) 1003-1011; DOI:10.1158/1535-7163.MCT-17-0930

  • Large Molecule Therapeutics
    Targeted Doxorubicin-Loaded Bacterially Derived Nano-Cells for the Treatment of Neuroblastoma
    Sharon M. Sagnella, Jennifer Trieu, Himanshu Brahmbhatt, Jennifer A. MacDiarmid, Alex MacMillan, Renee M. Whan, Christopher M. Fife, Joshua A. McCarroll, Andrew J. Gifford, David S. Ziegler and Maria Kavallaris
    Mol Cancer Ther May 1 2018 17 (5) 1012-1023; DOI:10.1158/1535-7163.MCT-17-0738

  • Large Molecule Therapeutics | AuthorChoice
    Potent Immune Modulation by MEDI6383, an Engineered Human OX40 Ligand IgG4P Fc Fusion Protein
    Michael D. Oberst, Catherine Augé, Chad Morris, Stacy Kentner, Kathy Mulgrew, Kelly McGlinchey, James Hair, Shino Hanabuchi, Qun Du, Melissa Damschroder, Hui Feng, Steven Eck, Nicholas Buss, Lolke de Haan, Andrew J. Pierce, Haesun Park, Andrew Sylwester, Michael K. Axthelm, Louis Picker, Nicholas P. Morris, Andrew Weinberg and Scott A. Hammond
    Mol Cancer Ther May 1 2018 17 (5) 1024-1038; DOI:10.1158/1535-7163.MCT-17-0200

  • Large Molecule Therapeutics | AuthorChoice
    ABT-165, a Dual Variable Domain Immunoglobulin (DVD-Ig) Targeting DLL4 and VEGF, Demonstrates Superior Efficacy and Favorable Safety Profiles in Preclinical Models
    Yingchun Li, Jonathan A. Hickson, Dominic J. Ambrosi, Deanna L. Haasch, Kelly D. Foster-Duke, Lucia J. Eaton, Enrico L. DiGiammarino, Sanjay C. Panchal, Fang Jiang, Sarah R. Mudd, Catherine Zhang, Surekha S. Akella, Wenqing Gao, Sherry L. Ralston, Louie Naumovski, Jijie Gu and Susan E. Morgan-Lappe
    Mol Cancer Ther May 1 2018 17 (5) 1039-1050; DOI:10.1158/1535-7163.MCT-17-0800

Cancer Biology and Translational Studies

  • Cancer Biology and Translational Studies
    Small Molecule–Mediated Activation of RAS Elicits Biphasic Modulation of Phospho-ERK Levels that Are Regulated through Negative Feedback on SOS1
    Jennifer E. Howes, Denis T. Akan, Michael C. Burns, Olivia W. Rossanese, Alex G. Waterson and Stephen W. Fesik
    Mol Cancer Ther May 1 2018 17 (5) 1051-1060; DOI:10.1158/1535-7163.MCT-17-0666

  • Cancer Biology and Translational Studies | AuthorChoice
    MicroRNA-203 Inhibits Long Noncoding RNA HOTAIR and Regulates Tumorigenesis through Epithelial-to-mesenchymal Transition Pathway in Renal Cell Carcinoma
    Pritha Dasgupta, Priyanka Kulkarni, Shahana Majid, Varahram Shahryari, Yutaka Hashimoto, Nadeem S. Bhat, Marisa Shiina, Guoren Deng, Sharanjot Saini, Z. Laura Tabatabai, Soichiro Yamamura, Yuichiro Tanaka and Rajvir Dahiya
    Mol Cancer Ther May 1 2018 17 (5) 1061-1069; DOI:10.1158/1535-7163.MCT-17-0925

  • Cancer Biology and Translational Studies
    Inhibition of the Histone H3K27 Demethylase UTX Enhances Tumor Cell Radiosensitivity
    Barbara H. Rath, Isabella Waung, Kevin Camphausen and Philip J. Tofilon
    Mol Cancer Ther May 1 2018 17 (5) 1070-1078; DOI:10.1158/1535-7163.MCT-17-1053

  • Cancer Biology and Translational Studies
    EGF Receptor and mTORC1 Are Novel Therapeutic Targets in Nonseminomatous Germ Cell Tumors
    Kenneth S. Chen, Nicholas J. Fustino, Abhay A. Shukla, Emily K. Stroup, Albert Budhipramono, Christina Ateek, Sarai H. Stuart, Kiyoshi Yamaguchi, Payal Kapur, A. Lindsay Frazier, Lawrence Lum, Leendert H.J. Looijenga, Theodore W. Laetsch, Dinesh Rakheja and James F. Amatruda
    Mol Cancer Ther May 1 2018 17 (5) 1079-1089; DOI:10.1158/1535-7163.MCT-17-0137

  • Cancer Biology and Translational Studies
    p110α Inhibition Overcomes Stromal Cell–Mediated Ibrutinib Resistance in Mantle Cell Lymphoma
    Jiyu Guan, Dan Huang, Konstantin Yakimchuk and Sam Okret
    Mol Cancer Ther May 1 2018 17 (5) 1090-1100; DOI:10.1158/1535-7163.MCT-17-0784

  • Cancer Biology and Translational Studies
    Targeting PRPK Function Blocks Colon Cancer Metastasis
    Tatyana Zykova, Feng Zhu, Lei Wang, Haitao Li, Do Young Lim, Ke Yao, Eunmiri Roh, Sang-Pil Yoon, Hong-Gyum Kim, Ki Beom Bae, Weihong Wen, Seung Ho Shin, Janos Nadas, Yan Li, Weiya Ma, Ann M. Bode and Zigang Dong
    Mol Cancer Ther May 1 2018 17 (5) 1101-1113; DOI:10.1158/1535-7163.MCT-17-0628

Companion Diagnostic, Pharmacogenomic, and Cancer Biomarkers

  • Companion Diagnostic, Pharmacogenomic, and Cancer Biomarkers
    Analysis of Tissue and Circulating Tumor DNA by Next-Generation Sequencing of Hepatocellular Carcinoma: Implications for Targeted Therapeutics
    Sadakatsu Ikeda, Jordan S. Lim and Razelle Kurzrock
    Mol Cancer Ther May 1 2018 17 (5) 1114-1122; DOI:10.1158/1535-7163.MCT-17-0604

  • Companion Diagnostic, Pharmacogenomic, and Cancer Biomarkers
    Correlation of Somatic Genomic Alterations Between Tissue Genomics and ctDNA Employing Next-Generation Sequencing: Analysis of Lung and Gastrointestinal Cancers
    Omer M. Toor, Zaheer Ahmed, Waled Bahaj, Urooge Boda, Lee S. Cummings, Megan E. McNally, Kevin F. Kennedy, Timothy J. Pluard, Arif Hussain, Janakiraman Subramanian and Ashiq Masood
    Mol Cancer Ther May 1 2018 17 (5) 1123-1132; DOI:10.1158/1535-7163.MCT-17-1015

Models and Technologies

  • Models and Technologies
    Anti-HER2 scFv-Directed Extracellular Vesicle-Mediated mRNA-Based Gene Delivery Inhibits Growth of HER2-Positive Human Breast Tumor Xenografts by Prodrug Activation
    Jing-Hung Wang, Alexis V. Forterre, Jinjing Zhao, Daniel O. Frimannsson, Alain Delcayre, Travis J. Antes, Bradley Efron, Stefanie S. Jeffrey, Mark D. Pegram and A.C. Matin
    Mol Cancer Ther May 1 2018 17 (5) 1133-1142; DOI:10.1158/1535-7163.MCT-17-0827

Correction

  • Correction | Free Article
    Correction: PRIMA-1Met/APR-246 Displays High Antitumor Activity in Multiple Myeloma by Induction of p73 and Noxa
    Mol Cancer Ther May 1 2018 17 (5) 1143-1143; DOI:10.1158/1535-7163.MCT-18-0096

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Molecular Cancer Therapeutics: 17 (5)
May 2018
Volume 17, Issue 5
  • Table of Contents
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Issue Highlights

  • Preclinical Activity of Abemaciclib Alone or in Combination with Antimitotic and Targeted Therapies in Breast Cancer
  • Antitumor Activity of Osimertinib, an Irreversible Mutant-Selective EGFR Tyrosine Kinase Inhibitor, in NSCLC Harboring EGFR Exon 20 Insertions
  • Targeted Doxorubicin-Loaded Bacterially Derived Nano-Cells for the Treatment of Neuroblastoma
  • In Vitro and In Vivo Activity of IMGN853, an Antibody–Drug Conjugate Targeting Folate Receptor Alpha Linked to DM4, in Biologically Aggressive Endometrial Cancers

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Molecular Cancer Therapeutics
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