A Patient-derived Xenograft Model of Pancreatic Neuroendocrine Tumors Identifies Sapanisertib as a Possible New Treatment for Everolimus-resistant Tumors

Chester E. Chamberlain; Michael S. German; Katherine Yang; Jason Wang; Henry VanBrocklin; Melanie Regan; Kevan M. Shokat; Gregory S. Ducker; Grace E. Kim; Byron Hann; David B. Donner; Robert S. Warren; Alan P. Venook; Emily K. Bergsland; Danny Lee; Yucheng Wang; Eric K. Nakakura

doi:10.1158/1535-7163.MCT-17-1204

Cancer Biology and Translational Studies

A Patient-derived Xenograft Model of Pancreatic Neuroendocrine Tumors Identifies Sapanisertib as a Possible New Treatment for Everolimus-resistant Tumors

Chester E. Chamberlain, Michael S. German, Katherine Yang, Jason Wang, Henry VanBrocklin, Melanie Regan, Kevan M. Shokat, Gregory S. Ducker, Grace E. Kim, Byron Hann, David B. Donner, Robert S. Warren, Alan P. Venook, Emily K. Bergsland, Danny Lee, Yucheng Wang and Eric K. Nakakura

Chester E. Chamberlain

Center for Regeneration Medicine, University of California, San Francisco, California.Diabetes Center, University of California, San Francisco, California.Department of Medicine, University of California, San Francisco, California.

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For correspondence: eric.nakakura@ucsf.edu chester.chamberlain@ucsf.edu

Michael S. German

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Katherine Yang

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Jason Wang

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Henry VanBrocklin

Department of Radiology and Biomedical Imaging, University of California, San Francisco, California.

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Melanie Regan

Department of Radiology and Biomedical Imaging, University of California, San Francisco, California.

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Kevan M. Shokat

Department of Cellular Molecular Pharmacology, University of California, San Francisco, California.

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ORCID record for Kevan M. Shokat

Gregory S. Ducker

Department of Cellular Molecular Pharmacology, University of California, San Francisco, California.

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Grace E. Kim

Department of Pathology, University of California, San Francisco, California.

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Byron Hann

Helen Diller Family HDF Comprehensive Cancer Center, University of California, San Francisco, California.

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David B. Donner

Helen Diller Family HDF Comprehensive Cancer Center, University of California, San Francisco, California.Department of Surgery, University of California, San Francisco, California.

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Robert S. Warren

Helen Diller Family HDF Comprehensive Cancer Center, University of California, San Francisco, California.Department of Surgery, University of California, San Francisco, California.

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Alan P. Venook

Department of Medicine, University of California, San Francisco, California.Helen Diller Family HDF Comprehensive Cancer Center, University of California, San Francisco, California.

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Emily K. Bergsland

Department of Medicine, University of California, San Francisco, California.Helen Diller Family HDF Comprehensive Cancer Center, University of California, San Francisco, California.

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Danny Lee

Helen Diller Family HDF Comprehensive Cancer Center, University of California, San Francisco, California.Department of Surgery, University of California, San Francisco, California.

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Yucheng Wang

Helen Diller Family HDF Comprehensive Cancer Center, University of California, San Francisco, California.Department of Surgery, University of California, San Francisco, California.

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Eric K. Nakakura

Helen Diller Family HDF Comprehensive Cancer Center, University of California, San Francisco, California.Department of Surgery, University of California, San Francisco, California.

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For correspondence: eric.nakakura@ucsf.edu chester.chamberlain@ucsf.edu

DOI: 10.1158/1535-7163.MCT-17-1204 Published December 2018

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December 2018
Volume 17, Issue 12

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A Patient-derived Xenograft Model of Pancreatic Neuroendocrine Tumors Identifies Sapanisertib as a Possible New Treatment for Everolimus-resistant Tumors

Mol Cancer Ther December 1 2018 (17) (12) 2702-2709; DOI: 10.1158/1535-7163.MCT-17-1204

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A Patient-derived Xenograft Model of Pancreatic Neuroendocrine Tumors Identifies Sapanisertib as a Possible New Treatment for Everolimus-resistant Tumors