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Molecular Cancer Therapeutics
Molecular Cancer Therapeutics
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Cancer Biology and Translational Studies

A Patient-derived Xenograft Model of Pancreatic Neuroendocrine Tumors Identifies Sapanisertib as a Possible New Treatment for Everolimus-resistant Tumors

Chester E. Chamberlain, Michael S. German, Katherine Yang, Jason Wang, Henry VanBrocklin, Melanie Regan, Kevan M. Shokat, Gregory S. Ducker, Grace E. Kim, Byron Hann, David B. Donner, Robert S. Warren, Alan P. Venook, Emily K. Bergsland, Danny Lee, Yucheng Wang and Eric K. Nakakura
Chester E. Chamberlain
1Center for Regeneration Medicine, University of California, San Francisco, California.
2Diabetes Center, University of California, San Francisco, California.
3Department of Medicine, University of California, San Francisco, California.
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  • For correspondence: eric.nakakura@ucsf.edu chester.chamberlain@ucsf.edu
Michael S. German
1Center for Regeneration Medicine, University of California, San Francisco, California.
2Diabetes Center, University of California, San Francisco, California.
3Department of Medicine, University of California, San Francisco, California.
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Katherine Yang
1Center for Regeneration Medicine, University of California, San Francisco, California.
2Diabetes Center, University of California, San Francisco, California.
3Department of Medicine, University of California, San Francisco, California.
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Jason Wang
1Center for Regeneration Medicine, University of California, San Francisco, California.
2Diabetes Center, University of California, San Francisco, California.
3Department of Medicine, University of California, San Francisco, California.
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Henry VanBrocklin
4Department of Radiology and Biomedical Imaging, University of California, San Francisco, California.
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Melanie Regan
4Department of Radiology and Biomedical Imaging, University of California, San Francisco, California.
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Kevan M. Shokat
5Department of Cellular Molecular Pharmacology, University of California, San Francisco, California.
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  • ORCID record for Kevan M. Shokat
Gregory S. Ducker
5Department of Cellular Molecular Pharmacology, University of California, San Francisco, California.
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Grace E. Kim
6Department of Pathology, University of California, San Francisco, California.
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Byron Hann
7Helen Diller Family HDF Comprehensive Cancer Center, University of California, San Francisco, California.
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David B. Donner
7Helen Diller Family HDF Comprehensive Cancer Center, University of California, San Francisco, California.
8Department of Surgery, University of California, San Francisco, California.
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Robert S. Warren
7Helen Diller Family HDF Comprehensive Cancer Center, University of California, San Francisco, California.
8Department of Surgery, University of California, San Francisco, California.
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Alan P. Venook
3Department of Medicine, University of California, San Francisco, California.
7Helen Diller Family HDF Comprehensive Cancer Center, University of California, San Francisco, California.
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Emily K. Bergsland
3Department of Medicine, University of California, San Francisco, California.
7Helen Diller Family HDF Comprehensive Cancer Center, University of California, San Francisco, California.
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Danny Lee
7Helen Diller Family HDF Comprehensive Cancer Center, University of California, San Francisco, California.
8Department of Surgery, University of California, San Francisco, California.
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Yucheng Wang
7Helen Diller Family HDF Comprehensive Cancer Center, University of California, San Francisco, California.
8Department of Surgery, University of California, San Francisco, California.
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Eric K. Nakakura
7Helen Diller Family HDF Comprehensive Cancer Center, University of California, San Francisco, California.
8Department of Surgery, University of California, San Francisco, California.
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  • For correspondence: eric.nakakura@ucsf.edu chester.chamberlain@ucsf.edu
DOI: 10.1158/1535-7163.MCT-17-1204 Published December 2018
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Article Information

Volume 17, Issue 12, pp. 2702-2709

DOI 
https://doi.org/10.1158/1535-7163.MCT-17-1204
PubMed 
30254185

Published By 
American Association for Cancer Research
Print ISSN 
1535-7163
Online ISSN 
1538-8514
History 
  • Received December 3, 2017
  • Revision received July 18, 2018
  • Accepted September 20, 2018
  • Published first September 25, 2018.

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  • Previous version (September 25, 2018 - 07:06).
  • You are viewing the most recent version of this article.
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©2018 American Association for Cancer Research.

Author Information

  1. Chester E. Chamberlain1,2,3,*,
  2. Michael S. German1,2,3,
  3. Katherine Yang1,2,3,
  4. Jason Wang1,2,3,
  5. Henry VanBrocklin4,
  6. Melanie Regan4,
  7. Kevan M. Shokat5,
  8. Gregory S. Ducker5,
  9. Grace E. Kim6,
  10. Byron Hann7,
  11. David B. Donner7,8,
  12. Robert S. Warren7,8,
  13. Alan P. Venook3,7,
  14. Emily K. Bergsland3,7,
  15. Danny Lee7,8,
  16. Yucheng Wang7,8, and
  17. Eric K. Nakakura7,8,*
  1. 1Center for Regeneration Medicine, University of California, San Francisco, California.
  2. 2Diabetes Center, University of California, San Francisco, California.
  3. 3Department of Medicine, University of California, San Francisco, California.
  4. 4Department of Radiology and Biomedical Imaging, University of California, San Francisco, California.
  5. 5Department of Cellular Molecular Pharmacology, University of California, San Francisco, California.
  6. 6Department of Pathology, University of California, San Francisco, California.
  7. 7Helen Diller Family HDF Comprehensive Cancer Center, University of California, San Francisco, California.
  8. 8Department of Surgery, University of California, San Francisco, California.
  1. ↵*Corresponding Authors:
    Eric K. Nakakura, University of California, 1600 Divisadero Street, A-724, San Francisco, CA 94143-1932. Phone: 415-353-9294; Fax: 415-353-9695; E-mail: eric.nakakura{at}ucsf.edu; Chester E. Chamberlain, chester.chamberlain{at}ucsf.edu
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Molecular Cancer Therapeutics: 17 (12)
December 2018
Volume 17, Issue 12
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A Patient-derived Xenograft Model of Pancreatic Neuroendocrine Tumors Identifies Sapanisertib as a Possible New Treatment for Everolimus-resistant Tumors
Chester E. Chamberlain, Michael S. German, Katherine Yang, Jason Wang, Henry VanBrocklin, Melanie Regan, Kevan M. Shokat, Gregory S. Ducker, Grace E. Kim, Byron Hann, David B. Donner, Robert S. Warren, Alan P. Venook, Emily K. Bergsland, Danny Lee, Yucheng Wang and Eric K. Nakakura
Mol Cancer Ther December 1 2018 (17) (12) 2702-2709; DOI: 10.1158/1535-7163.MCT-17-1204

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A Patient-derived Xenograft Model of Pancreatic Neuroendocrine Tumors Identifies Sapanisertib as a Possible New Treatment for Everolimus-resistant Tumors
Chester E. Chamberlain, Michael S. German, Katherine Yang, Jason Wang, Henry VanBrocklin, Melanie Regan, Kevan M. Shokat, Gregory S. Ducker, Grace E. Kim, Byron Hann, David B. Donner, Robert S. Warren, Alan P. Venook, Emily K. Bergsland, Danny Lee, Yucheng Wang and Eric K. Nakakura
Mol Cancer Ther December 1 2018 (17) (12) 2702-2709; DOI: 10.1158/1535-7163.MCT-17-1204
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