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Molecular Cancer Therapeutics
Molecular Cancer Therapeutics

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Cancer Biology and Translational Studies

TDP1 is Critical for the Repair of DNA Breaks Induced by Sapacitabine, a Nucleoside also Targeting ATM- and BRCA-Deficient Tumors

Muthana Al Abo, Hiroyuki Sasanuma, Xiaojun Liu, Vinodh N. Rajapakse, Shar-yin Huang, Evgeny Kiselev, Shunichi Takeda, William Plunkett and Yves Pommier
Muthana Al Abo
Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, NCI, NIH, Bethesda, Maryland.
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Hiroyuki Sasanuma
Department of Radiation Genetics, Kyoto University, Graduate School of Medicine, Yoshida Konoe, Sakyo-ku, Kyoto, Japan.
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Xiaojun Liu
Department of Experimental Therapeutics, University of Texas M.D. Anderson Cancer Center, Houston, Texas.
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Vinodh N. Rajapakse
Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, NCI, NIH, Bethesda, Maryland.
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Shar-yin Huang
Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, NCI, NIH, Bethesda, Maryland.
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Evgeny Kiselev
Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, NCI, NIH, Bethesda, Maryland.
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Shunichi Takeda
Department of Radiation Genetics, Kyoto University, Graduate School of Medicine, Yoshida Konoe, Sakyo-ku, Kyoto, Japan.
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William Plunkett
Department of Experimental Therapeutics, University of Texas M.D. Anderson Cancer Center, Houston, Texas.
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Yves Pommier
Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, NCI, NIH, Bethesda, Maryland.
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  • For correspondence: pommier@nih.gov
DOI: 10.1158/1535-7163.MCT-17-0110 Published November 2017
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ARTICLE USAGE: August 2017 to December 2019

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Total2196509803

Cited By

Article Information

Volume 16, Issue 11, pp. 2543-2551

DOI 
https://doi.org/10.1158/1535-7163.MCT-17-0110
PubMed 
28802254

Published By 
American Association for Cancer Research
Print ISSN 
1535-7163
Online ISSN 
1538-8514
History 
  • Received February 1, 2017
  • Revision received May 24, 2017
  • Accepted July 27, 2017
  • Published first August 11, 2017.

Article Versions

  • Previous version (August 11, 2017 - 09:25).
  • You are viewing the most recent version of this article.
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©2017 American Association for Cancer Research.

Author Information

  1. Muthana Al Abo1,
  2. Hiroyuki Sasanuma2,
  3. Xiaojun Liu3,
  4. Vinodh N. Rajapakse1,
  5. Shar-yin Huang1,
  6. Evgeny Kiselev1,
  7. Shunichi Takeda2,
  8. William Plunkett3, and
  9. Yves Pommier1,*
  1. 1Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, NCI, NIH, Bethesda, Maryland.
  2. 2Department of Radiation Genetics, Kyoto University, Graduate School of Medicine, Yoshida Konoe, Sakyo-ku, Kyoto, Japan.
  3. 3Department of Experimental Therapeutics, University of Texas M.D. Anderson Cancer Center, Houston, Texas.
  1. ↵*Corresponding Author:
    Yves Pommier, National Cancer Institute, Building 37, Room 5068, MD 20892-4255. Phone: 240-760-6142; Fax: 240-541-4475; E-mail: pommier{at}nih.gov
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Molecular Cancer Therapeutics: 16 (11)
November 2017
Volume 16, Issue 11
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TDP1 is Critical for the Repair of DNA Breaks Induced by Sapacitabine, a Nucleoside also Targeting ATM- and BRCA-Deficient Tumors
Muthana Al Abo, Hiroyuki Sasanuma, Xiaojun Liu, Vinodh N. Rajapakse, Shar-yin Huang, Evgeny Kiselev, Shunichi Takeda, William Plunkett and Yves Pommier
Mol Cancer Ther November 1 2017 (16) (11) 2543-2551; DOI: 10.1158/1535-7163.MCT-17-0110

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TDP1 is Critical for the Repair of DNA Breaks Induced by Sapacitabine, a Nucleoside also Targeting ATM- and BRCA-Deficient Tumors
Muthana Al Abo, Hiroyuki Sasanuma, Xiaojun Liu, Vinodh N. Rajapakse, Shar-yin Huang, Evgeny Kiselev, Shunichi Takeda, William Plunkett and Yves Pommier
Mol Cancer Ther November 1 2017 (16) (11) 2543-2551; DOI: 10.1158/1535-7163.MCT-17-0110
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Molecular Cancer Therapeutics
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