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Molecular Cancer Therapeutics
Molecular Cancer Therapeutics
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About the Cover

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ABOUT THE COVER
The extracellular matrix limits the efficacy of chemotherapy in pancreatic ductal adenocarcinoma (PDA) in part by active cell signaling. Discoidin domain receptor 1 (DDR1) is a receptor tyrosine kinase that binds fibrillar collagens and is expressed by PDA tumor cells. The image shows phosphorylated DDR1 staining in human PDA highlighting active collagen signaling in PDA tumor cells. Aguilera and colleagues demonstrate that pharmacologic inhibition of DDR1 with the small molecule 7rh substantially improves the efficacy of standard chemotherapy in robust preclinical models of PDA in the absence of additional normal tissue toxicity.

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Molecular Cancer Therapeutics: 16 (11)
November 2017
Volume 16, Issue 11
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Issue Highlights

  • The Selective Tie2 Inhibitor Rebastinib Blocks Recruitment and Function of Tie2Hi Macrophages in Breast Cancer and Pancreatic Neuroendocrine Tumors
  • Inhibition of the V-ATPase by Archazolid A: A New Strategy to Inhibit EMT
  • Inhibition of Discoidin Domain Receptor 1 Reduces Collagen-mediated Tumorigenicity in Pancreatic Ductal Adenocarcinoma
  • Tumor Mutational Burden as an Independent Predictor of Response to Immunotherapy in Diverse Cancers
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Copyright © 2021 by the American Association for Cancer Research.

Molecular Cancer Therapeutics
eISSN: 1538-8514
ISSN: 1535-7163

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