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Molecular Cancer Therapeutics
Molecular Cancer Therapeutics
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Table of Contents

Highlights

  • Highlights
    Highlights of This Issue
    Mol Cancer Ther January 1 2017 16 (1) 1-1;

Small Molecule Therapeutics

  • Small Molecule Therapeutics | AuthorChoice
    6α-Acetoxyanopterine: A Novel Structure Class of Mitotic Inhibitor Disrupting Microtubule Dynamics in Prostate Cancer Cells
    Claire Levrier, Martin C. Sadowski, Anja Rockstroh, Brian Gabrielli, Maria Kavallaris, Melanie Lehman, Rohan A. Davis and Colleen C. Nelson
    Mol Cancer Ther January 1 2017 16 (1) 3-15; DOI:10.1158/1535-7163.MCT-16-0325

  • Small Molecule Therapeutics
    TAS-116, a Novel Hsp90 Inhibitor, Selectively Enhances Radiosensitivity of Human Cancer Cells to X-rays and Carbon Ion Radiation
    Younghyun Lee, Shigeaki Sunada, Hirokazu Hirakawa, Akira Fujimori, Jac A. Nickoloff and Ryuichi Okayasu
    Mol Cancer Ther January 1 2017 16 (1) 16-24; DOI:10.1158/1535-7163.MCT-16-0573

  • Small Molecule Therapeutics | AuthorChoice
    Radiosensitization by the ATR Inhibitor AZD6738 through Generation of Acentric Micronuclei
    Magnus T. Dillon, Holly E. Barker, Malin Pedersen, Hind Hafsi, Shreerang A. Bhide, Kate L. Newbold, Christopher M. Nutting, Martin McLaughlin and Kevin J. Harrington
    Mol Cancer Ther January 1 2017 16 (1) 25-34; DOI:10.1158/1535-7163.MCT-16-0239

  • Small Molecule Therapeutics
    Inhibition of AKR1C3 Activation Overcomes Resistance to Abiraterone in Advanced Prostate Cancer
    Chengfei Liu, Cameron M. Armstrong, Wei Lou, Alan Lombard, Christopher P. Evans and Allen C. Gao
    Mol Cancer Ther January 1 2017 16 (1) 35-44; DOI:10.1158/1535-7163.MCT-16-0186

  • Small Molecule Therapeutics | AuthorChoice
    Identification and Validation of Compounds Selectively Killing Resistant Cancer: Delineating Cell Line–Specific Effects from P-Glycoprotein–Induced Toxicity
    András Füredi, Szilárd Tóth, Kornélia Szebényi, Veronika F.S. Pape, Dóra Türk, Nóra Kucsma, László Cervenak, József Tóvári and Gergely Szakács
    Mol Cancer Ther January 1 2017 16 (1) 45-56; DOI:10.1158/1535-7163.MCT-16-0333-T

  • Small Molecule Therapeutics
    N-Arachidonoyl Dopamine Inhibits NRAS Neoplastic Transformation by Suppressing Its Plasma Membrane Translocation
    Min Wu, Jinyan Huang, Jianming Zhang, Cyril Benes, Bo Jiao and Ruibao Ren
    Mol Cancer Ther January 1 2017 16 (1) 57-67; DOI:10.1158/1535-7163.MCT-16-0419

  • Small Molecule Therapeutics | AuthorChoice
    ASP5878, a Novel Inhibitor of FGFR1, 2, 3, and 4, Inhibits the Growth of FGF19-Expressing Hepatocellular Carcinoma
    Takashi Futami, Hidetsugu Okada, Rumi Kihara, Tatsuya Kawase, Ayako Nakayama, Tomoyuki Suzuki, Minoru Kameda, Nobuaki Shindoh, Tadashi Terasaka, Masaaki Hirano and Sadao Kuromitsu
    Mol Cancer Ther January 1 2017 16 (1) 68-75; DOI:10.1158/1535-7163.MCT-16-0188

  • Small Molecule Therapeutics
    Novel p21-Activated Kinase 4 (PAK4) Allosteric Modulators Overcome Drug Resistance and Stemness in Pancreatic Ductal Adenocarcinoma
    Amro Aboukameel, Irfana Muqbil, William Senapedis, Erkan Baloglu, Yosef Landesman, Sharon Shacham, Michael Kauffman, Philip A. Philip, Ramzi M. Mohammad and Asfar S. Azmi
    Mol Cancer Ther January 1 2017 16 (1) 76-87; DOI:10.1158/1535-7163.MCT-16-0205

  • Small Molecule Therapeutics
    Combinatorial Drug Screening Identifies Ewing Sarcoma–specific Sensitivities
    Branka Radic-Sarikas, Kalliopi P. Tsafou, Kristina B. Emdal, Theodore Papamarkou, Kilian V. M. Huber, Cornelia Mutz, Jeffrey A. Toretsky, Keiryn L. Bennett, Jesper V. Olsen, Søren Brunak, Heinrich Kovar and Giulio Superti-Furga
    Mol Cancer Ther January 1 2017 16 (1) 88-101; DOI:10.1158/1535-7163.MCT-16-0235

  • Small Molecule Therapeutics | AuthorChoice
    The mTORC1/2 Inhibitor AZD8055 Strengthens the Efficiency of the MEK Inhibitor Trametinib to Reduce the Mcl-1/[Bim and Puma] ratio and to Sensitize Ovarian Carcinoma Cells to ABT-737
    Cécile Pétigny-Lechartier, Charlène Duboc, Abdelghani Jebahi, Marie-Hélène Louis, Edwige Abeilard, Christophe Denoyelle, Pascal Gauduchon, Laurent Poulain and Marie Villedieu
    Mol Cancer Ther January 1 2017 16 (1) 102-115; DOI:10.1158/1535-7163.MCT-16-0342

Large Molecule Therapeutics

  • Large Molecule Therapeutics | AuthorChoice
    Optimization of a PEGylated Glucuronide-Monomethylauristatin E Linker for Antibody–Drug Conjugates
    Patrick J. Burke, Joseph Z. Hamilton, Scott C. Jeffrey, Joshua H. Hunter, Svetlana O. Doronina, Nicole M. Okeley, Jamie B. Miyamoto, Martha E. Anderson, Ivan J. Stone, Michelle L. Ulrich, Jessica K. Simmons, Erica E. McKinney, Peter D. Senter and Robert P. Lyon
    Mol Cancer Ther January 1 2017 16 (1) 116-123; DOI:10.1158/1535-7163.MCT-16-0343

  • Large Molecule Therapeutics | AuthorChoice
    Establishment of the In Vivo Efficacy of Pretargeted Radioimmunotherapy Utilizing Inverse Electron Demand Diels-Alder Click Chemistry
    Jacob L. Houghton, Rosemery Membreno, Dalya Abdel-Atti, Kristen M. Cunanan, Sean Carlin, Wolfgang W. Scholz, Pat B. Zanzonico, Jason S. Lewis and Brian M. Zeglis
    Mol Cancer Ther January 1 2017 16 (1) 124-133; DOI:10.1158/1535-7163.MCT-16-0503

  • Large Molecule Therapeutics
    Preclinical Efficacy of an Antibody–Drug Conjugate Targeting Mesothelin Correlates with Quantitative 89Zr-ImmunoPET
    Anton G.T. Terwisscha van Scheltinga, Annie Ogasawara, Glenn Pacheco, Alexander N. Vanderbilt, Jeff N. Tinianow, Nidhi Gupta, Dongwei Li, Ron Firestein, Jan Marik, Suzie J. Scales and Simon-Peter Williams
    Mol Cancer Ther January 1 2017 16 (1) 134-142; DOI:10.1158/1535-7163.MCT-16-0449

Cancer Biology and Signal Transduction

  • Cancer Biology and Signal Transduction
    MENA Confers Resistance to Paclitaxel in Triple-Negative Breast Cancer
    Madeleine J. Oudin, Lucie Barbier, Claudia Schäfer, Tatsiana Kosciuk, Miles A. Miller, Sangyoon Han, Oliver Jonas, Douglas A. Lauffenburger and Frank B. Gertler
    Mol Cancer Ther January 1 2017 16 (1) 143-155; DOI:10.1158/1535-7163.MCT-16-0413

  • Cancer Biology and Signal Transduction
    Interference with the HSF1/HSP70/BAG3 Pathway Primes Glioma Cells to Matrix Detachment and BH3 Mimetic–Induced Apoptosis
    Patrick Antonietti, Benedikt Linder, Stephanie Hehlgans, Iris C. Mildenberger, Michael C. Burger, Simone Fulda, Joachim P. Steinbach, Florian Gessler, Franz Rödel, Michel Mittelbronn and Donat Kögel
    Mol Cancer Ther January 1 2017 16 (1) 156-168; DOI:10.1158/1535-7163.MCT-16-0262

  • Cancer Biology and Signal Transduction
    Digitalis-like Compounds Facilitate Non-Medullary Thyroid Cancer Redifferentiation through Intracellular Ca2+, FOS, and Autophagy-Dependent Pathways
    Marika H. Tesselaar, Thomas Crezee, Herman G. Swarts, Danny Gerrits, Otto C. Boerman, Jan B. Koenderink, Hendrik G. Stunnenberg, Mihai G. Netea, Johannes W.A. Smit, Romana T. Netea-Maier and Theo S. Plantinga
    Mol Cancer Ther January 1 2017 16 (1) 169-181; DOI:10.1158/1535-7163.MCT-16-0460

  • Cancer Biology and Signal Transduction
    Simvastatin-Induced Apoptosis in Osteosarcoma Cells: A Key Role of RhoA-AMPK/p38 MAPK Signaling in Antitumor Activity
    Walied A. Kamel, Eiji Sugihara, Hiroyuki Nobusue, Sayaka Yamaguchi-Iwai, Nobuyuki Onishi, Kenta Maki, Yumi Fukuchi, Koichi Matsuo, Akihiro Muto, Hideyuki Saya and Takatsune Shimizu
    Mol Cancer Ther January 1 2017 16 (1) 182-192; DOI:10.1158/1535-7163.MCT-16-0499

  • Cancer Biology and Signal Transduction
    Pharmacological Inhibition of Myocardin-related Transcription Factor Pathway Blocks Lung Metastases of RhoC-Overexpressing Melanoma
    Andrew J. Haak, Kathryn M. Appleton, Erika M. Lisabeth, Sean A. Misek, Yajing Ji, Susan M. Wade, Jessica L. Bell, Cheryl E. Rockwell, Merlin Airik, Melanie A. Krook, Scott D. Larsen, Monique Verhaegen, Elizabeth R. Lawlor and Richard R. Neubig
    Mol Cancer Ther January 1 2017 16 (1) 193-204; DOI:10.1158/1535-7163.MCT-16-0482

  • Cancer Biology and Signal Transduction
    Penfluridol Represses Integrin Expression in Breast Cancer through Induction of Reactive Oxygen Species and Downregulation of Sp Transcription Factors
    Erik Hedrick, Xi Li and Stephen Safe
    Mol Cancer Ther January 1 2017 16 (1) 205-216; DOI:10.1158/1535-7163.MCT-16-0451

  • Cancer Biology and Signal Transduction
    Trifluoperazine, a Well-Known Antipsychotic, Inhibits Glioblastoma Invasion by Binding to Calmodulin and Disinhibiting Calcium Release Channel IP3R
    Seokmin Kang, Jinpyo Hong, Jung Moo Lee, Hyo Eun Moon, Borami Jeon, Jungil Choi, Nal Ae Yoon, Sun Ha Paek, Eun Joo Roh, C. Justin Lee and Sang Soo Kang
    Mol Cancer Ther January 1 2017 16 (1) 217-227; DOI:10.1158/1535-7163.MCT-16-0169-T

Companion Diagnostics and Cancer Biomarkers

  • Companion Diagnostics and Cancer Biomarkers | AuthorChoice
    HER2 Status in Advanced or Metastatic Gastric, Esophageal, or Gastroesophageal Adenocarcinoma for Entry to the TRIO-013/LOGiC Trial of Lapatinib
    Michael F. Press, Catherine E. Ellis, Robert C. Gagnon, Tobias J. Grob, Marc Buyse, Ivonne Villalobos, Zhiyong Liang, Shafei Wu, Yung-Jue Bang, Shu-Kui Qin, Hyun Cheol Chung, Jianming Xu, Joon Oh Park, Krzysztof Jeziorski, Karen Afenjar, Yanling Ma, Monica C. Estrada, Douglas M. Robinson, Stefan J. Scherer, Guido Sauter, J. Randolph Hecht and Dennis J. Slamon
    Mol Cancer Ther January 1 2017 16 (1) 228-238; DOI:10.1158/1535-7163.MCT-15-0887

  • Companion Diagnostics and Cancer Biomarkers
    Clinicopathological and Functional Significance of RECQL1 Helicase in Sporadic Breast Cancers
    Arvind Arora, Swetha Parvathaneni, Mohammed A. Aleskandarany, Devika Agarwal, Reem Ali, Tarek Abdel-Fatah, Andrew R. Green, Graham R. Ball, Emad A. Rakha, Ian O. Ellis, Sudha Sharma and Srinivasan Madhusudan
    Mol Cancer Ther January 1 2017 16 (1) 239-250; DOI:10.1158/1535-7163.MCT-16-0290

Models and Technologies

  • Models and Technologies
    Enhanced Oncolytic Activities of the Telomerase-Specific Replication-Competent Adenovirus Expressing Short-Hairpin RNA against Dicer
    Mitsuhiro Machitani, Fuminori Sakurai, Keisaku Wakabayashi, Masashi Tachibana, Toshiyoshi Fujiwara and Hiroyuki Mizuguchi
    Mol Cancer Ther January 1 2017 16 (1) 251-259; DOI:10.1158/1535-7163.MCT-16-0383

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Molecular Cancer Therapeutics: 16 (1)
January 2017
Volume 16, Issue 1
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Editorial Board (PDF)

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Issue Highlights

  • MENA Confers Resistance to Paclitaxel in Triple-Negative Breast Cancer
  • Optimization of a PEGylated Glucuronide-Monomethylauristatin E Linker for Antibody–Drug Conjugates
  • Establishment of the In Vivo Efficacy of Pretargeted Radioimmunotherapy Utilizing Inverse Electron Demand Diels-Alder Click Chemistry
  • HER2 Status in Advanced or Metastatic Gastric, Esophageal, or Gastroesophageal Adenocarcinoma for Entry to the TRIO-013/LOGiC Trial of Lapatinib

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Molecular Cancer Therapeutics
eISSN: 1538-8514
ISSN: 1535-7163

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