Molecular Cancer Therapeutics: 16 (1)

Highlights

Highlights

Highlights of This Issue

Mol Cancer Ther January 1 2017 16 (1) 1-1;

Small Molecule Therapeutics

Small Molecule Therapeutics | AuthorChoice

6α-Acetoxyanopterine: A Novel Structure Class of Mitotic Inhibitor Disrupting Microtubule Dynamics in Prostate Cancer Cells

Claire Levrier, Martin C. Sadowski, Anja Rockstroh, Brian Gabrielli, Maria Kavallaris, Melanie Lehman, Rohan A. Davis and Colleen C. Nelson

Mol Cancer Ther January 1 2017 16 (1) 3-15; DOI:10.1158/1535-7163.MCT-16-0325
Small Molecule Therapeutics

TAS-116, a Novel Hsp90 Inhibitor, Selectively Enhances Radiosensitivity of Human Cancer Cells to X-rays and Carbon Ion Radiation

Younghyun Lee, Shigeaki Sunada, Hirokazu Hirakawa, Akira Fujimori, Jac A. Nickoloff and Ryuichi Okayasu

Mol Cancer Ther January 1 2017 16 (1) 16-24; DOI:10.1158/1535-7163.MCT-16-0573
Small Molecule Therapeutics | AuthorChoice

Radiosensitization by the ATR Inhibitor AZD6738 through Generation of Acentric Micronuclei

Magnus T. Dillon, Holly E. Barker, Malin Pedersen, Hind Hafsi, Shreerang A. Bhide, Kate L. Newbold, Christopher M. Nutting, Martin McLaughlin and Kevin J. Harrington

Mol Cancer Ther January 1 2017 16 (1) 25-34; DOI:10.1158/1535-7163.MCT-16-0239
Small Molecule Therapeutics

Inhibition of AKR1C3 Activation Overcomes Resistance to Abiraterone in Advanced Prostate Cancer

Chengfei Liu, Cameron M. Armstrong, Wei Lou, Alan Lombard, Christopher P. Evans and Allen C. Gao

Mol Cancer Ther January 1 2017 16 (1) 35-44; DOI:10.1158/1535-7163.MCT-16-0186
Small Molecule Therapeutics | AuthorChoice

Identification and Validation of Compounds Selectively Killing Resistant Cancer: Delineating Cell Line–Specific Effects from P-Glycoprotein–Induced Toxicity

András Füredi, Szilárd Tóth, Kornélia Szebényi, Veronika F.S. Pape, Dóra Türk, Nóra Kucsma, László Cervenak, József Tóvári and Gergely Szakács

Mol Cancer Ther January 1 2017 16 (1) 45-56; DOI:10.1158/1535-7163.MCT-16-0333-T
Small Molecule Therapeutics

N-Arachidonoyl Dopamine Inhibits NRAS Neoplastic Transformation by Suppressing Its Plasma Membrane Translocation

Min Wu, Jinyan Huang, Jianming Zhang, Cyril Benes, Bo Jiao and Ruibao Ren

Mol Cancer Ther January 1 2017 16 (1) 57-67; DOI:10.1158/1535-7163.MCT-16-0419
Small Molecule Therapeutics | AuthorChoice

ASP5878, a Novel Inhibitor of FGFR1, 2, 3, and 4, Inhibits the Growth of FGF19-Expressing Hepatocellular Carcinoma

Takashi Futami, Hidetsugu Okada, Rumi Kihara, Tatsuya Kawase, Ayako Nakayama, Tomoyuki Suzuki, Minoru Kameda, Nobuaki Shindoh, Tadashi Terasaka, Masaaki Hirano and Sadao Kuromitsu

Mol Cancer Ther January 1 2017 16 (1) 68-75; DOI:10.1158/1535-7163.MCT-16-0188
Small Molecule Therapeutics

Novel p21-Activated Kinase 4 (PAK4) Allosteric Modulators Overcome Drug Resistance and Stemness in Pancreatic Ductal Adenocarcinoma

Amro Aboukameel, Irfana Muqbil, William Senapedis, Erkan Baloglu, Yosef Landesman, Sharon Shacham, Michael Kauffman, Philip A. Philip, Ramzi M. Mohammad and Asfar S. Azmi

Mol Cancer Ther January 1 2017 16 (1) 76-87; DOI:10.1158/1535-7163.MCT-16-0205
Small Molecule Therapeutics

Combinatorial Drug Screening Identifies Ewing Sarcoma–specific Sensitivities

Branka Radic-Sarikas, Kalliopi P. Tsafou, Kristina B. Emdal, Theodore Papamarkou, Kilian V. M. Huber, Cornelia Mutz, Jeffrey A. Toretsky, Keiryn L. Bennett, Jesper V. Olsen, Søren Brunak, Heinrich Kovar and Giulio Superti-Furga

Mol Cancer Ther January 1 2017 16 (1) 88-101; DOI:10.1158/1535-7163.MCT-16-0235
Small Molecule Therapeutics | AuthorChoice

The mTORC1/2 Inhibitor AZD8055 Strengthens the Efficiency of the MEK Inhibitor Trametinib to Reduce the Mcl-1/[Bim and Puma] ratio and to Sensitize Ovarian Carcinoma Cells to ABT-737

Cécile Pétigny-Lechartier, Charlène Duboc, Abdelghani Jebahi, Marie-Hélène Louis, Edwige Abeilard, Christophe Denoyelle, Pascal Gauduchon, Laurent Poulain and Marie Villedieu

Mol Cancer Ther January 1 2017 16 (1) 102-115; DOI:10.1158/1535-7163.MCT-16-0342

Large Molecule Therapeutics

Large Molecule Therapeutics | AuthorChoice

Optimization of a PEGylated Glucuronide-Monomethylauristatin E Linker for Antibody–Drug Conjugates

Patrick J. Burke, Joseph Z. Hamilton, Scott C. Jeffrey, Joshua H. Hunter, Svetlana O. Doronina, Nicole M. Okeley, Jamie B. Miyamoto, Martha E. Anderson, Ivan J. Stone, Michelle L. Ulrich, Jessica K. Simmons, Erica E. McKinney, Peter D. Senter and Robert P. Lyon

Mol Cancer Ther January 1 2017 16 (1) 116-123; DOI:10.1158/1535-7163.MCT-16-0343
Large Molecule Therapeutics | AuthorChoice

Establishment of the In Vivo Efficacy of Pretargeted Radioimmunotherapy Utilizing Inverse Electron Demand Diels-Alder Click Chemistry

Jacob L. Houghton, Rosemery Membreno, Dalya Abdel-Atti, Kristen M. Cunanan, Sean Carlin, Wolfgang W. Scholz, Pat B. Zanzonico, Jason S. Lewis and Brian M. Zeglis

Mol Cancer Ther January 1 2017 16 (1) 124-133; DOI:10.1158/1535-7163.MCT-16-0503
Large Molecule Therapeutics

Preclinical Efficacy of an Antibody–Drug Conjugate Targeting Mesothelin Correlates with Quantitative ⁸⁹Zr-ImmunoPET

Anton G.T. Terwisscha van Scheltinga, Annie Ogasawara, Glenn Pacheco, Alexander N. Vanderbilt, Jeff N. Tinianow, Nidhi Gupta, Dongwei Li, Ron Firestein, Jan Marik, Suzie J. Scales and Simon-Peter Williams

Mol Cancer Ther January 1 2017 16 (1) 134-142; DOI:10.1158/1535-7163.MCT-16-0449

Cancer Biology and Signal Transduction

Cancer Biology and Signal Transduction

MENA Confers Resistance to Paclitaxel in Triple-Negative Breast Cancer

Madeleine J. Oudin, Lucie Barbier, Claudia Schäfer, Tatsiana Kosciuk, Miles A. Miller, Sangyoon Han, Oliver Jonas, Douglas A. Lauffenburger and Frank B. Gertler

Mol Cancer Ther January 1 2017 16 (1) 143-155; DOI:10.1158/1535-7163.MCT-16-0413
Cancer Biology and Signal Transduction

Interference with the HSF1/HSP70/BAG3 Pathway Primes Glioma Cells to Matrix Detachment and BH3 Mimetic–Induced Apoptosis

Patrick Antonietti, Benedikt Linder, Stephanie Hehlgans, Iris C. Mildenberger, Michael C. Burger, Simone Fulda, Joachim P. Steinbach, Florian Gessler, Franz Rödel, Michel Mittelbronn and Donat Kögel

Mol Cancer Ther January 1 2017 16 (1) 156-168; DOI:10.1158/1535-7163.MCT-16-0262
Cancer Biology and Signal Transduction

Digitalis-like Compounds Facilitate Non-Medullary Thyroid Cancer Redifferentiation through Intracellular Ca²⁺, FOS, and Autophagy-Dependent Pathways

Marika H. Tesselaar, Thomas Crezee, Herman G. Swarts, Danny Gerrits, Otto C. Boerman, Jan B. Koenderink, Hendrik G. Stunnenberg, Mihai G. Netea, Johannes W.A. Smit, Romana T. Netea-Maier and Theo S. Plantinga

Mol Cancer Ther January 1 2017 16 (1) 169-181; DOI:10.1158/1535-7163.MCT-16-0460
Cancer Biology and Signal Transduction

Simvastatin-Induced Apoptosis in Osteosarcoma Cells: A Key Role of RhoA-AMPK/p38 MAPK Signaling in Antitumor Activity

Walied A. Kamel, Eiji Sugihara, Hiroyuki Nobusue, Sayaka Yamaguchi-Iwai, Nobuyuki Onishi, Kenta Maki, Yumi Fukuchi, Koichi Matsuo, Akihiro Muto, Hideyuki Saya and Takatsune Shimizu

Mol Cancer Ther January 1 2017 16 (1) 182-192; DOI:10.1158/1535-7163.MCT-16-0499
Cancer Biology and Signal Transduction

Pharmacological Inhibition of Myocardin-related Transcription Factor Pathway Blocks Lung Metastases of RhoC-Overexpressing Melanoma

Andrew J. Haak, Kathryn M. Appleton, Erika M. Lisabeth, Sean A. Misek, Yajing Ji, Susan M. Wade, Jessica L. Bell, Cheryl E. Rockwell, Merlin Airik, Melanie A. Krook, Scott D. Larsen, Monique Verhaegen, Elizabeth R. Lawlor and Richard R. Neubig

Mol Cancer Ther January 1 2017 16 (1) 193-204; DOI:10.1158/1535-7163.MCT-16-0482
Cancer Biology and Signal Transduction

Penfluridol Represses Integrin Expression in Breast Cancer through Induction of Reactive Oxygen Species and Downregulation of Sp Transcription Factors

Erik Hedrick, Xi Li and Stephen Safe

Mol Cancer Ther January 1 2017 16 (1) 205-216; DOI:10.1158/1535-7163.MCT-16-0451
Cancer Biology and Signal Transduction

Trifluoperazine, a Well-Known Antipsychotic, Inhibits Glioblastoma Invasion by Binding to Calmodulin and Disinhibiting Calcium Release Channel IP₃R

Seokmin Kang, Jinpyo Hong, Jung Moo Lee, Hyo Eun Moon, Borami Jeon, Jungil Choi, Nal Ae Yoon, Sun Ha Paek, Eun Joo Roh, C. Justin Lee and Sang Soo Kang

Mol Cancer Ther January 1 2017 16 (1) 217-227; DOI:10.1158/1535-7163.MCT-16-0169-T

Companion Diagnostics and Cancer Biomarkers

Companion Diagnostics and Cancer Biomarkers | AuthorChoice

HER2 Status in Advanced or Metastatic Gastric, Esophageal, or Gastroesophageal Adenocarcinoma for Entry to the TRIO-013/LOGiC Trial of Lapatinib

Michael F. Press, Catherine E. Ellis, Robert C. Gagnon, Tobias J. Grob, Marc Buyse, Ivonne Villalobos, Zhiyong Liang, Shafei Wu, Yung-Jue Bang, Shu-Kui Qin, Hyun Cheol Chung, Jianming Xu, Joon Oh Park, Krzysztof Jeziorski, Karen Afenjar, Yanling Ma, Monica C. Estrada, Douglas M. Robinson, Stefan J. Scherer, Guido Sauter, J. Randolph Hecht and Dennis J. Slamon

Mol Cancer Ther January 1 2017 16 (1) 228-238; DOI:10.1158/1535-7163.MCT-15-0887
Companion Diagnostics and Cancer Biomarkers

Clinicopathological and Functional Significance of RECQL1 Helicase in Sporadic Breast Cancers

Arvind Arora, Swetha Parvathaneni, Mohammed A. Aleskandarany, Devika Agarwal, Reem Ali, Tarek Abdel-Fatah, Andrew R. Green, Graham R. Ball, Emad A. Rakha, Ian O. Ellis, Sudha Sharma and Srinivasan Madhusudan

Mol Cancer Ther January 1 2017 16 (1) 239-250; DOI:10.1158/1535-7163.MCT-16-0290

Models and Technologies

Models and Technologies

Enhanced Oncolytic Activities of the Telomerase-Specific Replication-Competent Adenovirus Expressing Short-Hairpin RNA against Dicer

Mitsuhiro Machitani, Fuminori Sakurai, Keisaku Wakabayashi, Masashi Tachibana, Toshiyoshi Fujiwara and Hiroyuki Mizuguchi

Mol Cancer Ther January 1 2017 16 (1) 251-259; DOI:10.1158/1535-7163.MCT-16-0383

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Highlights

Small Molecule Therapeutics

Large Molecule Therapeutics

Cancer Biology and Signal Transduction

Companion Diagnostics and Cancer Biomarkers

Models and Technologies

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