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Molecular Cancer Therapeutics
Molecular Cancer Therapeutics
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About the Cover

Cover image

Cover image expansion

The cover shows the schematic of liposomal formulations for single drug–loaded nanoparticles of doxorubicin and carfilzomib (top and middle, respectively) and the carfilzomib and doxorubicin dual-loaded combination nanoparticle (bottom). Doxorubicin was chemically conjugated to a phospholipid via a labile hydrazone bond, while carfilzomib was passively loaded into the lipid bilayer. The dual drug–loaded combination nanoparticle demonstrated synergy in vitro and was more efficacious in inhibiting tumor growth in vivo than a combination of free drugs or single-agent liposomes. For more information, see the article by Ashley and colleagues beginning on page 1452.

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Molecular Cancer Therapeutics: 15 (7)
July 2016
Volume 15, Issue 7
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Issue Highlights

  • Dual Carfilzomib and Doxorubicin–Loaded Liposomal Nanoparticles for Synergistic Efficacy in Multiple Myeloma
  • An Artificially Designed Interfering lncRNA Expressed by Oncolytic Adenovirus Competitively Consumes OncomiRs to Exert Antitumor Efficacy in Hepatocellular Carcinoma
  • Plk1 Inhibitors in Cancer Therapy: From Laboratory to Clinics
  • Activating Transcription Factor 3 Expression as a Marker of Response to the Histone Deacetylase Inhibitor Pracinostat
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Copyright © 2021 by the American Association for Cancer Research.

Molecular Cancer Therapeutics
eISSN: 1538-8514
ISSN: 1535-7163

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