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Molecular Cancer Therapeutics
Molecular Cancer Therapeutics
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About the Cover

Cover image

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Orlistat is a FDA-approved antiobesity drug that shows anticancer effect in a wide range of cancers. However, off-target effects and poor bioavailability hinder its clinical translation as a repurposed new drug against triple-negative breast cancer (TNBC). Orlistat loaded in HEA-b-EHA polymeric micellar-nanoparticles improved the solubility, bioavailability, and therapeutic efficacy of orlistat in vitro in cells and in vivo in tumor xenografts of TNBC in mice. The cover image shows a schematic illustration of the orlistat-loaded HEA-b-EHA polymeric micelles with different functional moieties used for tumor targeting (folic acid) and imaging (DyLight-747-B1-NIR Dye) in living animals. The results of this study indicate that the orlistat packaged in HEA-b-EHA micellar-NP is a highly promising new drug formulation for TNBC therapy. For details, see the article by Paulmurugan and colleagues on page 221.

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Molecular Cancer Therapeutics: 15 (2)
February 2016
Volume 15, Issue 2
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Issue Highlights

  • Folate Receptor–Targeted Polymeric Micellar Nanocarriers for Delivery of Orlistat as a Repurposed Drug against Triple-Negative Breast Cancer
  • GC1118, an Anti-EGFR Antibody with a Distinct Binding Epitope and Superior Inhibitory Activity against High-Affinity EGFR Ligands
  • 2-Deoxy-Glucose Downregulates Endothelial AKT and ERK via Interference with N-Linked Glycosylation, Induction of Endoplasmic Reticulum Stress, and GSK3β Activation
  • Human Leukocyte Antigen–Presented Macrophage Migration Inhibitory Factor Is a Surface Biomarker and Potential Therapeutic Target for Ovarian Cancer
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Molecular Cancer Therapeutics
eISSN: 1538-8514
ISSN: 1535-7163

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