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Molecular Cancer Therapeutics
Molecular Cancer Therapeutics
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Cancer Biology and Signal Transduction

The PI3K/Akt Pathway Regulates Oxygen Metabolism via Pyruvate Dehydrogenase (PDH)-E1α Phosphorylation

George J. Cerniglia, Souvik Dey, Shannon M. Gallagher-Colombo, Natalie A. Daurio, Stephen Tuttle, Theresa M. Busch, Alexander Lin, Ramon Sun, Tatiana V. Esipova, Sergei A. Vinogradov, Nicholas Denko, Constantinos Koumenis and Amit Maity
George J. Cerniglia
1Department of Radiation Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
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Souvik Dey
1Department of Radiation Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
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Shannon M. Gallagher-Colombo
1Department of Radiation Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
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Natalie A. Daurio
2Pharmacology Graduate Group, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
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Stephen Tuttle
1Department of Radiation Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
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Theresa M. Busch
1Department of Radiation Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
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Alexander Lin
1Department of Radiation Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
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Ramon Sun
3Department of Radiation Oncology, Ohio State University School of Medicine, Columbus, Ohio.
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Tatiana V. Esipova
4Department of Biochemistry and Biophysics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
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Sergei A. Vinogradov
4Department of Biochemistry and Biophysics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
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Nicholas Denko
3Department of Radiation Oncology, Ohio State University School of Medicine, Columbus, Ohio.
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Constantinos Koumenis
1Department of Radiation Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
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Amit Maity
1Department of Radiation Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
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  • For correspondence: maity@uphs.upenn.edu
DOI: 10.1158/1535-7163.MCT-14-0888 Published August 2015
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Article Information

Volume 14, Issue 8, pp. 1928-1938

DOI 
https://doi.org/10.1158/1535-7163.MCT-14-0888
PubMed 
25995437

Published By 
American Association for Cancer Research
Print ISSN 
1535-7163
Online ISSN 
1538-8514
History 
  • Received October 21, 2014
  • Revision received April 20, 2015
  • Accepted May 12, 2015
  • Published first May 20, 2015.

Article Versions

  • Previous version (May 20, 2015 - 11:40).
  • Previous version (July 20, 2015 - 08:42).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2015 American Association for Cancer Research.

Author Information

  1. George J. Cerniglia1,
  2. Souvik Dey1,
  3. Shannon M. Gallagher-Colombo1,
  4. Natalie A. Daurio2,
  5. Stephen Tuttle1,
  6. Theresa M. Busch1,
  7. Alexander Lin1,
  8. Ramon Sun3,
  9. Tatiana V. Esipova4,
  10. Sergei A. Vinogradov4,
  11. Nicholas Denko3,
  12. Constantinos Koumenis1, and
  13. Amit Maity1,*
  1. 1Department of Radiation Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
  2. 2Pharmacology Graduate Group, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
  3. 3Department of Radiation Oncology, Ohio State University School of Medicine, Columbus, Ohio.
  4. 4Department of Biochemistry and Biophysics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
  1. ↵*Corresponding Author:
    Amit Maity, University of Pennsylvania School of Medicine, TRC 2 West, 3400 Civic Center Boulevard, Philadelphia, PA 19104. Phone: 215-662-2428; Fax: 215-349-8952; E-mail: maity{at}uphs.upenn.edu
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Molecular Cancer Therapeutics: 14 (8)
August 2015
Volume 14, Issue 8
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The PI3K/Akt Pathway Regulates Oxygen Metabolism via Pyruvate Dehydrogenase (PDH)-E1α Phosphorylation
George J. Cerniglia, Souvik Dey, Shannon M. Gallagher-Colombo, Natalie A. Daurio, Stephen Tuttle, Theresa M. Busch, Alexander Lin, Ramon Sun, Tatiana V. Esipova, Sergei A. Vinogradov, Nicholas Denko, Constantinos Koumenis and Amit Maity
Mol Cancer Ther August 1 2015 (14) (8) 1928-1938; DOI: 10.1158/1535-7163.MCT-14-0888

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The PI3K/Akt Pathway Regulates Oxygen Metabolism via Pyruvate Dehydrogenase (PDH)-E1α Phosphorylation
George J. Cerniglia, Souvik Dey, Shannon M. Gallagher-Colombo, Natalie A. Daurio, Stephen Tuttle, Theresa M. Busch, Alexander Lin, Ramon Sun, Tatiana V. Esipova, Sergei A. Vinogradov, Nicholas Denko, Constantinos Koumenis and Amit Maity
Mol Cancer Ther August 1 2015 (14) (8) 1928-1938; DOI: 10.1158/1535-7163.MCT-14-0888
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Molecular Cancer Therapeutics
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