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Molecular Cancer Therapeutics
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Cancer Biology and Signal Transduction

Targeted Blockade of JAK/STAT3 Signaling Inhibits Ovarian Carcinoma Growth

Galina Gritsina, Fang Xiao, Shane W. O'Brien, Rashid Gabbasov, Marisa A. Maglaty, Ren-Huan Xu, Roshan J. Thapa, Yan Zhou, Emmanuelle Nicolas, Samuel Litwin, Siddharth Balachandran, Luis J. Sigal, Dennis Huszar and Denise C. Connolly
Galina Gritsina
1Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania.
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Fang Xiao
1Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania.
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Shane W. O'Brien
1Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania.
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Rashid Gabbasov
1Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania.
2Kazan (Volga Region) Federal University, Kazan, Russia.
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Marisa A. Maglaty
1Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania.
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Ren-Huan Xu
3Immune Cell Development and Host Defense Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania.
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Roshan J. Thapa
3Immune Cell Development and Host Defense Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania.
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Yan Zhou
4Biostatistics Facility, Fox Chase Cancer Center, Philadelphia, Pennsylvania.
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Emmanuelle Nicolas
5Genomics Facility, Fox Chase Cancer Center, Philadelphia, Pennsylvania.
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Samuel Litwin
4Biostatistics Facility, Fox Chase Cancer Center, Philadelphia, Pennsylvania.
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Siddharth Balachandran
3Immune Cell Development and Host Defense Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania.
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Luis J. Sigal
3Immune Cell Development and Host Defense Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania.
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Dennis Huszar
6AstraZeneca Oncology iMed, Waltham, Massachusetts.
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Denise C. Connolly
1Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania.
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  • For correspondence: Denise.Connolly@fccc.edu
DOI: 10.1158/1535-7163.MCT-14-0800 Published April 2015
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Article Information

Volume 14, Issue 4, pp. 1035-1047

DOI 
https://doi.org/10.1158/1535-7163.MCT-14-0800
PubMed 
25646015

Published By 
American Association for Cancer Research
Print ISSN 
1535-7163
Online ISSN 
1538-8514
History 
  • Received September 17, 2014
  • Revision received December 18, 2014
  • Accepted January 26, 2015
  • Published first February 2, 2015.

Article Versions

  • Previous version (February 2, 2015 - 11:43).
  • Previous version (March 27, 2015 - 07:01).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2015 American Association for Cancer Research.

Author Information

  1. Galina Gritsina1,
  2. Fang Xiao1,
  3. Shane W. O'Brien1,
  4. Rashid Gabbasov1,2,
  5. Marisa A. Maglaty1,
  6. Ren-Huan Xu3,
  7. Roshan J. Thapa3,
  8. Yan Zhou4,
  9. Emmanuelle Nicolas5,
  10. Samuel Litwin4,
  11. Siddharth Balachandran3,
  12. Luis J. Sigal3,
  13. Dennis Huszar6, and
  14. Denise C. Connolly1,*
  1. 1Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania.
  2. 2Kazan (Volga Region) Federal University, Kazan, Russia.
  3. 3Immune Cell Development and Host Defense Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania.
  4. 4Biostatistics Facility, Fox Chase Cancer Center, Philadelphia, Pennsylvania.
  5. 5Genomics Facility, Fox Chase Cancer Center, Philadelphia, Pennsylvania.
  6. 6AstraZeneca Oncology iMed, Waltham, Massachusetts.
  1. ↵*Corresponding Author:
    Denise C. Connolly, Molecular Therapeutics Program, Fox Chase Cancer Center, 333 Cottman Avenue, W310, Philadelphia, PA 19111. Phone: 215-728-1004; Fax: 215-728-2741; E-mail: Denise.Connolly{at}fccc.edu
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Molecular Cancer Therapeutics: 14 (4)
April 2015
Volume 14, Issue 4
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Targeted Blockade of JAK/STAT3 Signaling Inhibits Ovarian Carcinoma Growth
Galina Gritsina, Fang Xiao, Shane W. O'Brien, Rashid Gabbasov, Marisa A. Maglaty, Ren-Huan Xu, Roshan J. Thapa, Yan Zhou, Emmanuelle Nicolas, Samuel Litwin, Siddharth Balachandran, Luis J. Sigal, Dennis Huszar and Denise C. Connolly
Mol Cancer Ther April 1 2015 (14) (4) 1035-1047; DOI: 10.1158/1535-7163.MCT-14-0800

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Targeted Blockade of JAK/STAT3 Signaling Inhibits Ovarian Carcinoma Growth
Galina Gritsina, Fang Xiao, Shane W. O'Brien, Rashid Gabbasov, Marisa A. Maglaty, Ren-Huan Xu, Roshan J. Thapa, Yan Zhou, Emmanuelle Nicolas, Samuel Litwin, Siddharth Balachandran, Luis J. Sigal, Dennis Huszar and Denise C. Connolly
Mol Cancer Ther April 1 2015 (14) (4) 1035-1047; DOI: 10.1158/1535-7163.MCT-14-0800
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Molecular Cancer Therapeutics
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