Table of Contents

Small Molecule Therapeutics

• Small Molecule Therapeutics

  Antitumor Activity of the MEK Inhibitor TAK-733 against Melanoma Cell Lines and Patient-Derived Tumor Explants

  Lindsey N. Micel, John J. Tentler, Aik-Choon Tan, Heather M. Selby, Kelsey L. Brunkow, Kelli M. Robertson, S. Lindsey Davis, Peter J. Klauck, Todd M. Pitts, Esha Gangolli, Robyn Fabrey, Shawn M. O'Connell, Patrick W. Vincent and S. Gail Eckhardt

  Mol Cancer Ther February 1 2015 14 (2) 317-325; DOI:10.1158/1535-7163.MCT-13-1012

  
  
• Small Molecule Therapeutics

  Identification of Novel Radiosensitizers in a High-Throughput, Cell-Based Screen for DSB Repair Inhibitors

  Alexander G. Goglia, Robert Delsite, Antonio N. Luz, David Shahbazian, Ahmed F. Salem, Ranjini K. Sundaram, Jeanne Chiaravalli, Petrus J. Hendrikx, Jennifer A. Wilshire, Maria Jasin, Harriet M. Kluger, J. Fraser Glickman, Simon N. Powell and Ranjit S. Bindra

  Mol Cancer Ther February 1 2015 14 (2) 326-342; DOI:10.1158/1535-7163.MCT-14-0765

  
  
• Small Molecule Therapeutics

  A Novel Compound, NK150460, Exhibits Selective Antitumor Activity against Breast Cancer Cell Lines through Activation of Aryl Hydrocarbon Receptor

  Kazuteru Fukasawa, Shigehide Kagaya, Sakiko Maruyama, Shunsuke Kuroiwa, Kuniko Masuda, Yoshio Kameyama, Yoshitaka Satoh, Yuichi Akatsu, Arihiro Tomura, Kiyohiro Nishikawa, Shigeo Horie and Yuh-ichiro Ichikawa

  Mol Cancer Ther February 1 2015 14 (2) 343-354; DOI:10.1158/1535-7163.MCT-14-0158

  
  
• Small Molecule Therapeutics

  Berberine Induces Senescence of Human Glioblastoma Cells by Downregulating the EGFR–MEK–ERK Signaling Pathway

  Qiao Liu, Xiuhua Xu, Minnan Zhao, Zhao Wei, Xi Li, Xiyu Zhang, Zhaojian Liu, Yaoqin Gong and Changshun Shao

  Mol Cancer Ther February 1 2015 14 (2) 355-363; DOI:10.1158/1535-7163.MCT-14-0634

  
  
• Small Molecule Therapeutics

  Evaluation of the In Vitro and In Vivo Efficacy of the JAK Inhibitor AZD1480 against JAK-Mutated Acute Lymphoblastic Leukemia

  Santi Suryani, Lauryn S. Bracken, Richard C. Harvey, Keith C.S. Sia, Hernan Carol, I-Ming Chen, Kathryn Evans, Philipp A. Dietrich, Kathryn G. Roberts, Raushan T. Kurmasheva, Catherine A. Billups, Charles G. Mullighan, Cheryl L. Willman, Mignon L. Loh, Stephen P. Hunger, Peter J. Houghton, Malcolm A. Smith and Richard B. Lock

  Mol Cancer Ther February 1 2015 14 (2) 364-374; DOI:10.1158/1535-7163.MCT-14-0647

  
  
• Small Molecule Therapeutics | AuthorChoice

  AMG 925 Is a Dual FLT3/CDK4 Inhibitor with the Potential to Overcome FLT3 Inhibitor Resistance in Acute Myeloid Leukemia

  Cong Li, Liqin Liu, Lingming Liang, Zhen Xia, Zhihong Li, Xianghong Wang, Lawrence R. McGee, Katie Newhall, Angus Sinclair, Alexander Kamb, Dineli Wickramasinghe and Kang Dai

  Mol Cancer Ther February 1 2015 14 (2) 375-383; DOI:10.1158/1535-7163.MCT-14-0388

  
  
• Small Molecule Therapeutics

  The Selective Intravenous Inhibitor of the MET Tyrosine Kinase SAR125844 Inhibits Tumor Growth in MET-Amplified Cancer

  Coumaran Egile, Mireille Kenigsberg, Christine Delaisi, Françoise Bégassat, Véronique Do-Vale, Jessica Mestadier, Fabrice Bonche, Tsiala Bénard, Jean-Paul Nicolas, Sandrine Valence, Céline Lefranc, Elisa Francesconi, Christelle Castell, Anne-Marie Lefebvre, Conception Nemecek, Loreley Calvet and Hélène Goulaouic

  Mol Cancer Ther February 1 2015 14 (2) 384-394; DOI:10.1158/1535-7163.MCT-14-0428

  
  
• Small Molecule Therapeutics

  MLN0128, an ATP-Competitive mTOR Kinase Inhibitor with Potent In Vitro and In Vivo Antitumor Activity, as Potential Therapy for Bone and Soft-Tissue Sarcoma

  Emily K. Slotkin, Parag P. Patwardhan, Shyamprasad D. Vasudeva, Elisa de Stanchina, William D. Tap and Gary K. Schwartz

  Mol Cancer Ther February 1 2015 14 (2) 395-406; DOI:10.1158/1535-7163.MCT-14-0711

  
  
• Small Molecule Therapeutics

  A Preclinical Evaluation of SKLB261, a Multikinase Inhibitor of EGFR/Src/VEGFR2, as a Therapeutic Agent against Pancreatic Cancer

  Youli Pan, Mingwu Zheng, Lei Zhong, Jiao Yang, Shu Zhou, Ya Qin, Rong Xiang, Yuzong Chen and Sheng-Yong Yang

  Mol Cancer Ther February 1 2015 14 (2) 407-418; DOI:10.1158/1535-7163.MCT-14-0485

  
  
• Small Molecule Therapeutics

  Radiotherapy Followed by Aurora Kinase Inhibition Targets Tumor-Propagating Cells in Human Glioblastoma

  Nan Li, Dustin J. Maly, Yvan H. Chanthery, Daniel W. Sirkis, Jean L. Nakamura, Mitchel S. Berger, C. David James, Kevan M. Shokat, William A. Weiss and Anders I. Persson

  Mol Cancer Ther February 1 2015 14 (2) 419-428; DOI:10.1158/1535-7163.MCT-14-0526

  
  
• Small Molecule Therapeutics

  Dual PI3K/mTOR Inhibitors, GSK2126458 and PKI-587, Suppress Tumor Progression and Increase Radiosensitivity in Nasopharyngeal Carcinoma

  Tongxin Liu, Quanquan Sun, Qi Li, Hua Yang, Yuqin Zhang, Rong Wang, Xiaoshan Lin, Dong Xiao, Yawei Yuan, Longhua Chen and Wei Wang

  Mol Cancer Ther February 1 2015 14 (2) 429-439; DOI:10.1158/1535-7163.MCT-14-0548

  
  
• Small Molecule Therapeutics

  The Use of Dipeptide Derivatives of 5-Aminolaevulinic Acid Promotes Their Entry to Tumor Cells and Improves Tumor Selectivity of Photodynamic Therapy

  Gabriela Di Venosa, Pablo Vallecorsa, Francesca Giuntini, Leandro Mamone, Alcira Batlle, Silvia Vanzuli, Angeles Juarranz, Alexander J. MacRobert, Ian M. Eggleston and Adriana Casas

  Mol Cancer Ther February 1 2015 14 (2) 440-451; DOI:10.1158/1535-7163.MCT-13-1084

  
  
• Small Molecule Therapeutics

  A Novel Photodynamic Therapy Targeting Cancer Cells and Tumor-Associated Macrophages

  Noriyuki Hayashi, Hiromi Kataoka, Shigenobu Yano, Mamoru Tanaka, Kazuhiro Moriwaki, Haruo Akashi, Shugo Suzuki, Yoshinori Mori, Eiji Kubota, Satoshi Tanida, Satoru Takahashi and Takashi Joh

  Mol Cancer Ther February 1 2015 14 (2) 452-460; DOI:10.1158/1535-7163.MCT-14-0348

  
  
• Small Molecule Therapeutics

  A Multicenter Phase I Study of Pazopanib in Combination with Paclitaxel in First-Line Treatment of Patients with Advanced Solid Tumors

  Kari L. Kendra, Ruth Plummer, Ravi Salgia, Mary E. R. O'Brien, Elaine M. Paul, A. Benjamin Suttle, Natalie Compton, Chun-Fang Xu, Lone H. Ottesen and Miguel A. Villalona-Calero

  Mol Cancer Ther February 1 2015 14 (2) 461-469; DOI:10.1158/1535-7163.MCT-14-0431