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Molecular Cancer Therapeutics
Molecular Cancer Therapeutics
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Table of Contents

Highlights

  • Highlights
    Highlights of This Issue
    Mol Cancer Ther February 1 2015 14 (2) 315-315;

Small Molecule Therapeutics

  • Small Molecule Therapeutics
    Antitumor Activity of the MEK Inhibitor TAK-733 against Melanoma Cell Lines and Patient-Derived Tumor Explants
    Lindsey N. Micel, John J. Tentler, Aik-Choon Tan, Heather M. Selby, Kelsey L. Brunkow, Kelli M. Robertson, S. Lindsey Davis, Peter J. Klauck, Todd M. Pitts, Esha Gangolli, Robyn Fabrey, Shawn M. O'Connell, Patrick W. Vincent and S. Gail Eckhardt
    Mol Cancer Ther February 1 2015 14 (2) 317-325; DOI:10.1158/1535-7163.MCT-13-1012

  • Small Molecule Therapeutics
    Identification of Novel Radiosensitizers in a High-Throughput, Cell-Based Screen for DSB Repair Inhibitors
    Alexander G. Goglia, Robert Delsite, Antonio N. Luz, David Shahbazian, Ahmed F. Salem, Ranjini K. Sundaram, Jeanne Chiaravalli, Petrus J. Hendrikx, Jennifer A. Wilshire, Maria Jasin, Harriet M. Kluger, J. Fraser Glickman, Simon N. Powell and Ranjit S. Bindra
    Mol Cancer Ther February 1 2015 14 (2) 326-342; DOI:10.1158/1535-7163.MCT-14-0765

  • Small Molecule Therapeutics
    A Novel Compound, NK150460, Exhibits Selective Antitumor Activity against Breast Cancer Cell Lines through Activation of Aryl Hydrocarbon Receptor
    Kazuteru Fukasawa, Shigehide Kagaya, Sakiko Maruyama, Shunsuke Kuroiwa, Kuniko Masuda, Yoshio Kameyama, Yoshitaka Satoh, Yuichi Akatsu, Arihiro Tomura, Kiyohiro Nishikawa, Shigeo Horie and Yuh-ichiro Ichikawa
    Mol Cancer Ther February 1 2015 14 (2) 343-354; DOI:10.1158/1535-7163.MCT-14-0158

  • Small Molecule Therapeutics
    Berberine Induces Senescence of Human Glioblastoma Cells by Downregulating the EGFR–MEK–ERK Signaling Pathway
    Qiao Liu, Xiuhua Xu, Minnan Zhao, Zhao Wei, Xi Li, Xiyu Zhang, Zhaojian Liu, Yaoqin Gong and Changshun Shao
    Mol Cancer Ther February 1 2015 14 (2) 355-363; DOI:10.1158/1535-7163.MCT-14-0634

  • Small Molecule Therapeutics
    Evaluation of the In Vitro and In Vivo Efficacy of the JAK Inhibitor AZD1480 against JAK-Mutated Acute Lymphoblastic Leukemia
    Santi Suryani, Lauryn S. Bracken, Richard C. Harvey, Keith C.S. Sia, Hernan Carol, I-Ming Chen, Kathryn Evans, Philipp A. Dietrich, Kathryn G. Roberts, Raushan T. Kurmasheva, Catherine A. Billups, Charles G. Mullighan, Cheryl L. Willman, Mignon L. Loh, Stephen P. Hunger, Peter J. Houghton, Malcolm A. Smith and Richard B. Lock
    Mol Cancer Ther February 1 2015 14 (2) 364-374; DOI:10.1158/1535-7163.MCT-14-0647

  • Small Molecule Therapeutics | AuthorChoice
    AMG 925 Is a Dual FLT3/CDK4 Inhibitor with the Potential to Overcome FLT3 Inhibitor Resistance in Acute Myeloid Leukemia
    Cong Li, Liqin Liu, Lingming Liang, Zhen Xia, Zhihong Li, Xianghong Wang, Lawrence R. McGee, Katie Newhall, Angus Sinclair, Alexander Kamb, Dineli Wickramasinghe and Kang Dai
    Mol Cancer Ther February 1 2015 14 (2) 375-383; DOI:10.1158/1535-7163.MCT-14-0388

  • Small Molecule Therapeutics
    The Selective Intravenous Inhibitor of the MET Tyrosine Kinase SAR125844 Inhibits Tumor Growth in MET-Amplified Cancer
    Coumaran Egile, Mireille Kenigsberg, Christine Delaisi, Françoise Bégassat, Véronique Do-Vale, Jessica Mestadier, Fabrice Bonche, Tsiala Bénard, Jean-Paul Nicolas, Sandrine Valence, Céline Lefranc, Elisa Francesconi, Christelle Castell, Anne-Marie Lefebvre, Conception Nemecek, Loreley Calvet and Hélène Goulaouic
    Mol Cancer Ther February 1 2015 14 (2) 384-394; DOI:10.1158/1535-7163.MCT-14-0428

  • Small Molecule Therapeutics
    MLN0128, an ATP-Competitive mTOR Kinase Inhibitor with Potent In Vitro and In Vivo Antitumor Activity, as Potential Therapy for Bone and Soft-Tissue Sarcoma
    Emily K. Slotkin, Parag P. Patwardhan, Shyamprasad D. Vasudeva, Elisa de Stanchina, William D. Tap and Gary K. Schwartz
    Mol Cancer Ther February 1 2015 14 (2) 395-406; DOI:10.1158/1535-7163.MCT-14-0711

  • Small Molecule Therapeutics
    A Preclinical Evaluation of SKLB261, a Multikinase Inhibitor of EGFR/Src/VEGFR2, as a Therapeutic Agent against Pancreatic Cancer
    Youli Pan, Mingwu Zheng, Lei Zhong, Jiao Yang, Shu Zhou, Ya Qin, Rong Xiang, Yuzong Chen and Sheng-Yong Yang
    Mol Cancer Ther February 1 2015 14 (2) 407-418; DOI:10.1158/1535-7163.MCT-14-0485

  • Small Molecule Therapeutics
    Radiotherapy Followed by Aurora Kinase Inhibition Targets Tumor-Propagating Cells in Human Glioblastoma
    Nan Li, Dustin J. Maly, Yvan H. Chanthery, Daniel W. Sirkis, Jean L. Nakamura, Mitchel S. Berger, C. David James, Kevan M. Shokat, William A. Weiss and Anders I. Persson
    Mol Cancer Ther February 1 2015 14 (2) 419-428; DOI:10.1158/1535-7163.MCT-14-0526

  • Small Molecule Therapeutics
    Dual PI3K/mTOR Inhibitors, GSK2126458 and PKI-587, Suppress Tumor Progression and Increase Radiosensitivity in Nasopharyngeal Carcinoma
    Tongxin Liu, Quanquan Sun, Qi Li, Hua Yang, Yuqin Zhang, Rong Wang, Xiaoshan Lin, Dong Xiao, Yawei Yuan, Longhua Chen and Wei Wang
    Mol Cancer Ther February 1 2015 14 (2) 429-439; DOI:10.1158/1535-7163.MCT-14-0548

  • Small Molecule Therapeutics
    The Use of Dipeptide Derivatives of 5-Aminolaevulinic Acid Promotes Their Entry to Tumor Cells and Improves Tumor Selectivity of Photodynamic Therapy
    Gabriela Di Venosa, Pablo Vallecorsa, Francesca Giuntini, Leandro Mamone, Alcira Batlle, Silvia Vanzuli, Angeles Juarranz, Alexander J. MacRobert, Ian M. Eggleston and Adriana Casas
    Mol Cancer Ther February 1 2015 14 (2) 440-451; DOI:10.1158/1535-7163.MCT-13-1084

  • Small Molecule Therapeutics
    A Novel Photodynamic Therapy Targeting Cancer Cells and Tumor-Associated Macrophages
    Noriyuki Hayashi, Hiromi Kataoka, Shigenobu Yano, Mamoru Tanaka, Kazuhiro Moriwaki, Haruo Akashi, Shugo Suzuki, Yoshinori Mori, Eiji Kubota, Satoshi Tanida, Satoru Takahashi and Takashi Joh
    Mol Cancer Ther February 1 2015 14 (2) 452-460; DOI:10.1158/1535-7163.MCT-14-0348

  • Small Molecule Therapeutics
    A Multicenter Phase I Study of Pazopanib in Combination with Paclitaxel in First-Line Treatment of Patients with Advanced Solid Tumors
    Kari L. Kendra, Ruth Plummer, Ravi Salgia, Mary E. R. O'Brien, Elaine M. Paul, A. Benjamin Suttle, Natalie Compton, Chun-Fang Xu, Lone H. Ottesen and Miguel A. Villalona-Calero
    Mol Cancer Ther February 1 2015 14 (2) 461-469; DOI:10.1158/1535-7163.MCT-14-0431

Large Molecule Therapeutics

  • Large Molecule Therapeutics
    Novel Glycosylated VEGF Decoy Receptor Fusion Protein, VEGF-Grab, Efficiently Suppresses Tumor Angiogenesis and Progression
    Jung-Eun Lee, Chan Kim, Hannah Yang, Intae Park, Nuri Oh, Serenus Hua, Haneul Jeong, Hyun Joo An, Sun Chang Kim, Gyun Min Lee, Gou Young Koh and Ho Min Kim
    Mol Cancer Ther February 1 2015 14 (2) 470-479; DOI:10.1158/1535-7163.MCT-14-0968-T

  • Large Molecule Therapeutics | AuthorChoice
    Identification of LY2510924, a Novel Cyclic Peptide CXCR4 Antagonist That Exhibits Antitumor Activities in Solid Tumor and Breast Cancer Metastatic Models
    Sheng-Bin Peng, Xiaoyi Zhang, Donald Paul, Lisa M. Kays, Wendy Gough, Julie Stewart, Mark T. Uhlik, Qi Chen, Yu-Hua Hui, Maciej J. Zamek-Gliszczynski, John A. Wijsman, Kelly M. Credille and Liang Zeng Yan
    Mol Cancer Ther February 1 2015 14 (2) 480-490; DOI:10.1158/1535-7163.MCT-14-0850

  • Large Molecule Therapeutics
    SapC–DOPS Nanovesicles as Targeted Therapy for Lung Cancer
    Shuli Zhao, Zhengtao Chu, Victor M. Blanco, Yunzhong Nie, Yayi Hou and Xiaoyang Qi
    Mol Cancer Ther February 1 2015 14 (2) 491-498; DOI:10.1158/1535-7163.MCT-14-0661

Cancer Biology and Signal Transduction

  • Cancer Biology and Signal Transduction | AuthorChoice
    Tumor-Suppressor Role of Notch3 in Medullary Thyroid Carcinoma Revealed by Genetic and Pharmacological Induction
    Renata Jaskula-Sztul, Jacob Eide, Sara Tesfazghi, Ajitha Dammalapati, April D. Harrison, Xiao-Min Yu, Casi Scheinebeck, Gabrielle Winston-McPherson, Kevin R. Kupcho, Matthew B. Robers, Amrit K. Hundal, Weiping Tang and Herbert Chen
    Mol Cancer Ther February 1 2015 14 (2) 499-512; DOI:10.1158/1535-7163.MCT-14-0073

  • Cancer Biology and Signal Transduction
    Sunitinib Dose Escalation Overcomes Transient Resistance in Clear Cell Renal Cell Carcinoma and Is Associated with Epigenetic Modifications
    Remi Adelaiye, Eric Ciamporcero, Kiersten Marie Miles, Paula Sotomayor, Jonathan Bard, Maria Tsompana, Dylan Conroy, Li Shen, Swathi Ramakrishnan, Sheng-Yu Ku, Ashley Orillion, Joshua Prey, Gerald Fetterly, Michael Buck, Sreenivasulu Chintala, Georg A. Bjarnason and Roberto Pili
    Mol Cancer Ther February 1 2015 14 (2) 513-522; DOI:10.1158/1535-7163.MCT-14-0208

  • Cancer Biology and Signal Transduction
    Tumor-Associated Hyaluronan Limits Efficacy of Monoclonal Antibody Therapy
    Netai C. Singha, Tara Nekoroski, Chunmei Zhao, Rebecca Symons, Ping Jiang, Gregory I. Frost, Zhongdong Huang and H. Michael Shepard
    Mol Cancer Ther February 1 2015 14 (2) 523-532; DOI:10.1158/1535-7163.MCT-14-0580

  • Cancer Biology and Signal Transduction
    Combining Onartuzumab with Erlotinib Inhibits Growth of Non–Small Cell Lung Cancer with Activating EGFR Mutations and HGF Overexpression
    Yuji Sano, Eri Hashimoto, Noriaki Nakatani, Masaichi Abe, Yasuko Satoh, Kiyoaki Sakata, Toshihiko Fujii, Kaori Fujimoto-Ouchi, Masamichi Sugimoto, Shigehisa Nagahashi, Masahiro Aoki, Hiroshi Motegi, Eiichi Sasaki and Yasushi Yatabe
    Mol Cancer Ther February 1 2015 14 (2) 533-541; DOI:10.1158/1535-7163.MCT-14-0456

  • Cancer Biology and Signal Transduction
    Optimizing the Sequence of Anti-EGFR–Targeted Therapy in EGFR-Mutant Lung Cancer
    Catherine B. Meador, Hailing Jin, Elisa de Stanchina, Caroline A. Nebhan, Valentina Pirazzoli, Lu Wang, Pengcheng Lu, Huy Vuong, Katherine E. Hutchinson, Peilin Jia, Xi Chen, Rosana Eisenberg, Marc Ladanyi, Katerina Politi, Zhongming Zhao, Christine M. Lovly, Darren A.E. Cross and William Pao
    Mol Cancer Ther February 1 2015 14 (2) 542-552; DOI:10.1158/1535-7163.MCT-14-0723

  • Cancer Biology and Signal Transduction
    HAb18G/CD147 Promotes Radioresistance in Hepatocellular Carcinoma Cells: A Potential Role for Integrin β1 Signaling
    Jiao Wu, Yong Li, Ya-Zheng Dang, Hong-Xiang Gao, Jian-Li Jiang and Zhi-Nan Chen
    Mol Cancer Ther February 1 2015 14 (2) 553-563; DOI:10.1158/1535-7163.MCT-14-0618

  • Cancer Biology and Signal Transduction
    Glycogen Synthase Kinase 3β Sustains Invasion of Glioblastoma via the Focal Adhesion Kinase, Rac1, and c-Jun N-Terminal Kinase-Mediated Pathway
    Yuri Chikano, Takahiro Domoto, Takuya Furuta, Hemragul Sabit, Ayako Kitano-Tamura, Ilya V. Pyko, Takahisa Takino, Yoshimichi Sai, Yutaka Hayashi, Hiroshi Sato, Ken-ichi Miyamoto, Mitsutoshi Nakada and Toshinari Minamoto
    Mol Cancer Ther February 1 2015 14 (2) 564-574; DOI:10.1158/1535-7163.MCT-14-0479

  • Cancer Biology and Signal Transduction
    Clinical and Cellular Roles for TDP1 and TOP1 in Modulating Colorectal Cancer Response to Irinotecan
    Cornelia Meisenberg, Duncan C. Gilbert, Anthony Chalmers, Vikki Haley, Simon Gollins, Simon E. Ward and Sherif F. El-Khamisy
    Mol Cancer Ther February 1 2015 14 (2) 575-585; DOI:10.1158/1535-7163.MCT-14-0762

  • Cancer Biology and Signal Transduction
    Inhibition of the GTPase Rac1 Mediates the Antimigratory Effects of Metformin in Prostate Cancer Cells
    Béatrice Dirat, Isabelle Ader, Muriel Golzio, Fabienne Massa, Amel Mettouchi, Kathiane Laurent, Frédéric Larbret, Bernard Malavaud, Mireille Cormont, Emmanuel Lemichez, Olivier Cuvillier, Jean François Tanti and Frédéric Bost
    Mol Cancer Ther February 1 2015 14 (2) 586-596; DOI:10.1158/1535-7163.MCT-14-0102

  • Cancer Biology and Signal Transduction
    Targeting BRG1 Chromatin Remodeler via Its Bromodomain for Enhanced Tumor Cell Radiosensitivity In Vitro and In Vivo
    Su-Jung Kwon, Seul-Ki Lee, Juri Na, Shin-Ai Lee, Han-Sae Lee, Ji-Hye Park, June-Key Chung, Hyewon Youn and Jongbum Kwon
    Mol Cancer Ther February 1 2015 14 (2) 597-607; DOI:10.1158/1535-7163.MCT-14-0372

Companion Diagnostics and Cancer Biomarkers

  • Companion Diagnostics and Cancer Biomarkers | AuthorChoice
    Wee-1 Kinase Inhibition Overcomes Cisplatin Resistance Associated with High-Risk TP53 Mutations in Head and Neck Cancer through Mitotic Arrest Followed by Senescence
    Abdullah A. Osman, Marcus M. Monroe, Marcus V. Ortega Alves, Ameeta A. Patel, Panagiotis Katsonis, Alison L. Fitzgerald, David M. Neskey, Mitchell J. Frederick, Sang Hyeok Woo, Carlos Caulin, Teng-Kuei Hsu, Thomas O. McDonald, Marek Kimmel, Raymond E. Meyn, Olivier Lichtarge and Jeffrey N. Myers
    Mol Cancer Ther February 1 2015 14 (2) 608-619; DOI:10.1158/1535-7163.MCT-14-0735-T

  • Companion Diagnostics and Cancer Biomarkers
    IRS2 Copy Number Gain, KRAS and BRAF Mutation Status as Predictive Biomarkers for Response to the IGF-1R/IR Inhibitor BMS-754807 in Colorectal Cancer Cell Lines
    Fei Huang, Han Chang, Ann Greer, Stephen Hillerman, Karen A. Reeves, Warren Hurlburt, John Cogswell, Dharmesh Patel, Zhenhao Qi, Craig Fairchild, Rolf-Peter Ryseck, Tai W. Wong, Friedrich G. Finckenstein, Jeffrey Jackson and Joan M. Carboni
    Mol Cancer Ther February 1 2015 14 (2) 620-630; DOI:10.1158/1535-7163.MCT-14-0794-T

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Molecular Cancer Therapeutics: 14 (2)
February 2015
Volume 14, Issue 2
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Issue Highlights

  • Tumor-Associated Hyaluronan Limits Efficacy of Monoclonal Antibody Therapy
  • Tumor-Suppressor Role of Notch3 in Medullary Thyroid Carcinoma Revealed by Genetic and Pharmacological Induction
  • Identification of Novel Radiosensitizers in a High-Throughput, Cell-Based Screen for DSB Repair Inhibitors
  • Novel Glycosylated VEGF Decoy Receptor Fusion Protein, VEGF-Grab, Efficiently Suppresses Tumor Angiogenesis and Progression

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Molecular Cancer Therapeutics
eISSN: 1538-8514
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