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Molecular Cancer Therapeutics
Molecular Cancer Therapeutics
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About the Cover

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5-hydroxydecanoate (5-HD) is a potential neuroprotective drug in cortical neurons. Paclitaxel has a potent toxicity on neuron viability, neurite morphology, and synaptic formation. 5-HD, screened from compound libraries, exhibited the most significant neuroprotective effects against paclitaxel-induced neurotoxicity. Using an image-based high-content platform, 5-HD decreased paclitaxel-induced damage to viability, neurite outgrowth, and synaptogenesis in cortical neurons. For details, see the article by Chen and colleagues on page 2206.

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Molecular Cancer Therapeutics: 14 (10)
October 2015
Volume 14, Issue 10
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Issue Highlights

  • Integrating Image-Based High-Content Screening with Mouse Models Identifies 5-Hydroxydecanoate as a Neuroprotective Drug for Paclitaxel-Induced Neuropathy
  • Redesigning a Monospecific Anti-FGFR3 Antibody to Add Selectivity for FGFR2 and Expand Antitumor Activity
  • Sensitivity of Small Cell Lung Cancer to BET Inhibition Is Mediated by Regulation of ASCL1 Gene Expression
  • NSCLC Driven by DDR2 Mutation Is Sensitive to Dasatinib and JQ1 Combination Therapy
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Copyright © 2021 by the American Association for Cancer Research.

Molecular Cancer Therapeutics
eISSN: 1538-8514
ISSN: 1535-7163

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