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Molecular Cancer Therapeutics
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Cancer Biology and Signal Transduction

Inhibition of SIRT1 Signaling Sensitizes the Antitumor Activity of Silybin against Human Lung Adenocarcinoma Cells In Vitro and In Vivo

Zhenxing Liang, Yang Yang, Haibin Wang, Wei Yi, Xiaolong Yan, Juanjuan Yan, Yue Li, Yingtong Feng, Shiqiang Yu, Jian Yang, Zhenxiao Jin, Weixun Duan and Wensheng Chen
Zhenxing Liang
1Department of Cardiovascular Surgery, Xijing Hospital;
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Yang Yang
1Department of Cardiovascular Surgery, Xijing Hospital;
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Haibin Wang
4Department of Clinical Laboratory, The First Affiliated Hospital of General Hospital of PLA, Beijing, China
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Wei Yi
1Department of Cardiovascular Surgery, Xijing Hospital;
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Xiaolong Yan
2Department of Thoracic Surgery, Tangdu Hospital;
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Juanjuan Yan
3Department of Prosthodontics, School of Stomatology, The Fourth Military Medical University, Xi'an; and
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Yue Li
1Department of Cardiovascular Surgery, Xijing Hospital;
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Yingtong Feng
2Department of Thoracic Surgery, Tangdu Hospital;
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Shiqiang Yu
1Department of Cardiovascular Surgery, Xijing Hospital;
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Jian Yang
1Department of Cardiovascular Surgery, Xijing Hospital;
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Zhenxiao Jin
1Department of Cardiovascular Surgery, Xijing Hospital;
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Weixun Duan
1Department of Cardiovascular Surgery, Xijing Hospital;
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  • For correspondence: wenshengchen210@126.com weixunduan210@126.com
Wensheng Chen
1Department of Cardiovascular Surgery, Xijing Hospital;
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  • For correspondence: wenshengchen210@126.com weixunduan210@126.com
DOI: 10.1158/1535-7163.MCT-13-0942 Published July 2014
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Total219424191312

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Article Information

Volume 13, Issue 7, pp. 1860-1872

DOI 
https://doi.org/10.1158/1535-7163.MCT-13-0942
PubMed 
24798868

Published By 
American Association for Cancer Research
Print ISSN 
1535-7163
Online ISSN 
1538-8514
History 
  • Received November 13, 2013
  • Revision received March 27, 2014
  • Accepted April 24, 2014
  • Published first May 5, 2014.

Article Versions

  • Previous version (May 5, 2014 - 12:46).
  • Previous version (June 19, 2014 - 14:33).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2014 American Association for Cancer Research.

Author Information

  1. Zhenxing Liang1,
  2. Yang Yang1,
  3. Haibin Wang4,
  4. Wei Yi1,
  5. Xiaolong Yan2,
  6. Juanjuan Yan3,
  7. Yue Li1,
  8. Yingtong Feng2,
  9. Shiqiang Yu1,
  10. Jian Yang1,
  11. Zhenxiao Jin1,
  12. Weixun Duan1,*, and
  13. Wensheng Chen1,*
  1. Authors' Affiliations: 1Department of Cardiovascular Surgery, Xijing Hospital;
  2. 2Department of Thoracic Surgery, Tangdu Hospital;
  3. 3Department of Prosthodontics, School of Stomatology, The Fourth Military Medical University, Xi'an; and
  4. 4Department of Clinical Laboratory, The First Affiliated Hospital of General Hospital of PLA, Beijing, China
  1. ↵*Corresponding Authors:
    Wensheng Chen, Department of Cardiovascular Surgery, Xijing Hospital, The Fourth Military Medical University, 127 Changle West Road, Xi'an 710032, China. Phone: 86-29-8477-5314; Fax: 86-29-8321-0092; E-mail: wenshengchen210{at}126.com; and Weixun Duan, weixunduan210{at}126.com
  1. Z. Liang, Y. Yang, and Haibin Wang contributed equally to this work.

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Molecular Cancer Therapeutics: 13 (7)
July 2014
Volume 13, Issue 7
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Inhibition of SIRT1 Signaling Sensitizes the Antitumor Activity of Silybin against Human Lung Adenocarcinoma Cells In Vitro and In Vivo
Zhenxing Liang, Yang Yang, Haibin Wang, Wei Yi, Xiaolong Yan, Juanjuan Yan, Yue Li, Yingtong Feng, Shiqiang Yu, Jian Yang, Zhenxiao Jin, Weixun Duan and Wensheng Chen
Mol Cancer Ther July 1 2014 (13) (7) 1860-1872; DOI: 10.1158/1535-7163.MCT-13-0942

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Inhibition of SIRT1 Signaling Sensitizes the Antitumor Activity of Silybin against Human Lung Adenocarcinoma Cells In Vitro and In Vivo
Zhenxing Liang, Yang Yang, Haibin Wang, Wei Yi, Xiaolong Yan, Juanjuan Yan, Yue Li, Yingtong Feng, Shiqiang Yu, Jian Yang, Zhenxiao Jin, Weixun Duan and Wensheng Chen
Mol Cancer Ther July 1 2014 (13) (7) 1860-1872; DOI: 10.1158/1535-7163.MCT-13-0942
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