Particle replication in nonwetting templates (PRINT) is a novel soft lithography process developed to fabricate nanotherapeutics. PRINT nanoparticles improve plasma exposure and increase tumor accumulation of the encapsulated therapeutic. Metronomic delivery of PLGA-PRINT-docetaxel nanoparticles combined with systemic EZH2 siRNA delivery using chitosan nanoparticles resulted in robust antitumor effects in ovarian cancer mouse models. For details, see the article by Gharpure and colleagues on page 1750.