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Molecular Cancer Therapeutics
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Cancer Biology and Signal Transduction

KRAS Mutation Status Is Associated with Enhanced Dependency on Folate Metabolism Pathways in Non–Small Cell Lung Cancer Cells

Diarmuid M. Moran, Patricia B. Trusk, Karen Pry, Keren Paz, David Sidransky and Sarah S. Bacus
Diarmuid M. Moran
1Translational R&D Oncology Group, Quintiles, Westmont; 2Department of Pharmacology, University of Illinois at Chicago, Chicago, Illinois; 3Department of Oncology, Johns Hopkins School of Medicine, Baltimore, Maryland; and 4Champions Oncology, Inc., Hackensack, New Jersey and Baltimore, Maryland
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Patricia B. Trusk
1Translational R&D Oncology Group, Quintiles, Westmont; 2Department of Pharmacology, University of Illinois at Chicago, Chicago, Illinois; 3Department of Oncology, Johns Hopkins School of Medicine, Baltimore, Maryland; and 4Champions Oncology, Inc., Hackensack, New Jersey and Baltimore, Maryland
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Karen Pry
1Translational R&D Oncology Group, Quintiles, Westmont; 2Department of Pharmacology, University of Illinois at Chicago, Chicago, Illinois; 3Department of Oncology, Johns Hopkins School of Medicine, Baltimore, Maryland; and 4Champions Oncology, Inc., Hackensack, New Jersey and Baltimore, Maryland
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Keren Paz
1Translational R&D Oncology Group, Quintiles, Westmont; 2Department of Pharmacology, University of Illinois at Chicago, Chicago, Illinois; 3Department of Oncology, Johns Hopkins School of Medicine, Baltimore, Maryland; and 4Champions Oncology, Inc., Hackensack, New Jersey and Baltimore, Maryland
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David Sidransky
1Translational R&D Oncology Group, Quintiles, Westmont; 2Department of Pharmacology, University of Illinois at Chicago, Chicago, Illinois; 3Department of Oncology, Johns Hopkins School of Medicine, Baltimore, Maryland; and 4Champions Oncology, Inc., Hackensack, New Jersey and Baltimore, Maryland
1Translational R&D Oncology Group, Quintiles, Westmont; 2Department of Pharmacology, University of Illinois at Chicago, Chicago, Illinois; 3Department of Oncology, Johns Hopkins School of Medicine, Baltimore, Maryland; and 4Champions Oncology, Inc., Hackensack, New Jersey and Baltimore, Maryland
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Sarah S. Bacus
1Translational R&D Oncology Group, Quintiles, Westmont; 2Department of Pharmacology, University of Illinois at Chicago, Chicago, Illinois; 3Department of Oncology, Johns Hopkins School of Medicine, Baltimore, Maryland; and 4Champions Oncology, Inc., Hackensack, New Jersey and Baltimore, Maryland
1Translational R&D Oncology Group, Quintiles, Westmont; 2Department of Pharmacology, University of Illinois at Chicago, Chicago, Illinois; 3Department of Oncology, Johns Hopkins School of Medicine, Baltimore, Maryland; and 4Champions Oncology, Inc., Hackensack, New Jersey and Baltimore, Maryland
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DOI: 10.1158/1535-7163.MCT-13-0649 Published June 2014
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Article Information

Volume 13, Issue 6, pp. 1611-1624

DOI 
https://doi.org/10.1158/1535-7163.MCT-13-0649
PubMed 
24688052

Published By 
American Association for Cancer Research
Print ISSN 
1535-7163
Online ISSN 
1538-8514
History 
  • Received August 9, 2013
  • Revision received February 28, 2014
  • Accepted March 12, 2014
  • Published first March 31, 2014.

Article Versions

  • Previous version (March 31, 2014 - 12:22).
  • Previous version (May 20, 2014 - 12:42).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2014 American Association for Cancer Research.

Author Information

  1. Diarmuid M. Moran1,
  2. Patricia B. Trusk1,
  3. Karen Pry1,
  4. Keren Paz4,
  5. David Sidransky3,4, and
  6. Sarah S. Bacus1,2
  1. Authors' Affiliations: 1Translational R&D Oncology Group, Quintiles, Westmont; 2Department of Pharmacology, University of Illinois at Chicago, Chicago, Illinois; 3Department of Oncology, Johns Hopkins School of Medicine, Baltimore, Maryland; and 4Champions Oncology, Inc., Hackensack, New Jersey and Baltimore, Maryland
  1. Corresponding Authors:
    Sarah Bacus, Translational R&D Oncology Group, Quintiles, 777 Oakmont Lane, Westmont, IL 60559. Phone: 630-203-6211/630-203-6237; Fax: 630-7893-765/331-330-2658; E-mail: sarah.bacus{at}quintiles.com; and Diarmuid Moran, diarmuid.moran{at}quintiles.com
  1. D.M. Moran and P.B. Trusk contributed equally to this work.

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Molecular Cancer Therapeutics: 13 (6)
June 2014
Volume 13, Issue 6
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KRAS Mutation Status Is Associated with Enhanced Dependency on Folate Metabolism Pathways in Non–Small Cell Lung Cancer Cells
Diarmuid M. Moran, Patricia B. Trusk, Karen Pry, Keren Paz, David Sidransky and Sarah S. Bacus
Mol Cancer Ther June 1 2014 (13) (6) 1611-1624; DOI: 10.1158/1535-7163.MCT-13-0649

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KRAS Mutation Status Is Associated with Enhanced Dependency on Folate Metabolism Pathways in Non–Small Cell Lung Cancer Cells
Diarmuid M. Moran, Patricia B. Trusk, Karen Pry, Keren Paz, David Sidransky and Sarah S. Bacus
Mol Cancer Ther June 1 2014 (13) (6) 1611-1624; DOI: 10.1158/1535-7163.MCT-13-0649
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