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Small Molecule Therapeutics

Highly Active Combination of BRD4 Antagonist and Histone Deacetylase Inhibitor against Human Acute Myelogenous Leukemia Cells

Warren Fiskus, Sunil Sharma, Jun Qi, John A. Valenta, Leasha J. Schaub, Bhavin Shah, Karissa Peth, Bryce P. Portier, Melissa Rodriguez, Santhana G.T. Devaraj, Ming Zhan, Jianting Sheng, Swaminathan P. Iyer, James E. Bradner and Kapil N. Bhalla
Warren Fiskus
1Houston Methodist Research Institute, Houston, Texas; 2Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah; and 3Dana-Farber Cancer Institute, Boston, Massachusetts
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Sunil Sharma
1Houston Methodist Research Institute, Houston, Texas; 2Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah; and 3Dana-Farber Cancer Institute, Boston, Massachusetts
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Jun Qi
1Houston Methodist Research Institute, Houston, Texas; 2Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah; and 3Dana-Farber Cancer Institute, Boston, Massachusetts
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John A. Valenta
1Houston Methodist Research Institute, Houston, Texas; 2Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah; and 3Dana-Farber Cancer Institute, Boston, Massachusetts
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Leasha J. Schaub
1Houston Methodist Research Institute, Houston, Texas; 2Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah; and 3Dana-Farber Cancer Institute, Boston, Massachusetts
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Bhavin Shah
1Houston Methodist Research Institute, Houston, Texas; 2Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah; and 3Dana-Farber Cancer Institute, Boston, Massachusetts
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Karissa Peth
1Houston Methodist Research Institute, Houston, Texas; 2Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah; and 3Dana-Farber Cancer Institute, Boston, Massachusetts
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Bryce P. Portier
1Houston Methodist Research Institute, Houston, Texas; 2Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah; and 3Dana-Farber Cancer Institute, Boston, Massachusetts
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Melissa Rodriguez
1Houston Methodist Research Institute, Houston, Texas; 2Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah; and 3Dana-Farber Cancer Institute, Boston, Massachusetts
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Santhana G.T. Devaraj
1Houston Methodist Research Institute, Houston, Texas; 2Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah; and 3Dana-Farber Cancer Institute, Boston, Massachusetts
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Ming Zhan
1Houston Methodist Research Institute, Houston, Texas; 2Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah; and 3Dana-Farber Cancer Institute, Boston, Massachusetts
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Jianting Sheng
1Houston Methodist Research Institute, Houston, Texas; 2Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah; and 3Dana-Farber Cancer Institute, Boston, Massachusetts
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Swaminathan P. Iyer
1Houston Methodist Research Institute, Houston, Texas; 2Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah; and 3Dana-Farber Cancer Institute, Boston, Massachusetts
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James E. Bradner
1Houston Methodist Research Institute, Houston, Texas; 2Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah; and 3Dana-Farber Cancer Institute, Boston, Massachusetts
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Kapil N. Bhalla
1Houston Methodist Research Institute, Houston, Texas; 2Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah; and 3Dana-Farber Cancer Institute, Boston, Massachusetts
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DOI: 10.1158/1535-7163.MCT-13-0770 Published May 2014
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Total427754724418

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Article Information

Volume 13, Issue 5, pp. 1142-1154

DOI 
https://doi.org/10.1158/1535-7163.MCT-13-0770
PubMed 
24435446

Published By 
American Association for Cancer Research
Print ISSN 
1535-7163
Online ISSN 
1538-8514
History 
  • Received September 12, 2013
  • Revision received November 24, 2013
  • Accepted November 25, 2013
  • Published first January 16, 2014.

Article Versions

  • Previous version (January 16, 2014 - 14:31).
  • Previous version (April 18, 2014 - 06:57).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2014 American Association for Cancer Research.

Author Information

  1. Warren Fiskus1,
  2. Sunil Sharma2,
  3. Jun Qi3,
  4. John A. Valenta1,
  5. Leasha J. Schaub1,
  6. Bhavin Shah1,
  7. Karissa Peth1,
  8. Bryce P. Portier1,
  9. Melissa Rodriguez1,
  10. Santhana G.T. Devaraj1,
  11. Ming Zhan1,
  12. Jianting Sheng1,
  13. Swaminathan P. Iyer1,
  14. James E. Bradner3, and
  15. Kapil N. Bhalla1
  1. Authors' Affiliations: 1Houston Methodist Research Institute, Houston, Texas; 2Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah; and 3Dana-Farber Cancer Institute, Boston, Massachusetts
  1. Corresponding Author:
    Kapil N. Bhalla, Houston Methodist Research Institute, 6670 Bertner Ave., R9–113, Houston, TX 77030. Phone: 713-441-9113; Fax: 713-441-5349; E-mail: knbhalla{at}tmhs.org
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Molecular Cancer Therapeutics: 13 (5)
May 2014
Volume 13, Issue 5
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Highly Active Combination of BRD4 Antagonist and Histone Deacetylase Inhibitor against Human Acute Myelogenous Leukemia Cells
Warren Fiskus, Sunil Sharma, Jun Qi, John A. Valenta, Leasha J. Schaub, Bhavin Shah, Karissa Peth, Bryce P. Portier, Melissa Rodriguez, Santhana G.T. Devaraj, Ming Zhan, Jianting Sheng, Swaminathan P. Iyer, James E. Bradner and Kapil N. Bhalla
Mol Cancer Ther May 1 2014 (13) (5) 1142-1154; DOI: 10.1158/1535-7163.MCT-13-0770

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Highly Active Combination of BRD4 Antagonist and Histone Deacetylase Inhibitor against Human Acute Myelogenous Leukemia Cells
Warren Fiskus, Sunil Sharma, Jun Qi, John A. Valenta, Leasha J. Schaub, Bhavin Shah, Karissa Peth, Bryce P. Portier, Melissa Rodriguez, Santhana G.T. Devaraj, Ming Zhan, Jianting Sheng, Swaminathan P. Iyer, James E. Bradner and Kapil N. Bhalla
Mol Cancer Ther May 1 2014 (13) (5) 1142-1154; DOI: 10.1158/1535-7163.MCT-13-0770
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Molecular Cancer Therapeutics
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