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Molecular Cancer Therapeutics
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Cancer Biology and Signal Transduction

Synuclein γ Compromises Spindle Assembly Checkpoint and Renders Resistance to Antimicrotubule Drugs

Suyu Miao, Kejin Wu, Bo Zhang, Ziyi Weng, Mingjie Zhu, Yunshu Lu, Ramadas Krishna and Yuenian Eric Shi
Suyu Miao
1Department of Surgical Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing; Departments of 2General Surgery and 3Pathology, XinHua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China; 4Centre for Bioinformatics, School of Life Science, Pondicherry University, Puducherry, India; and 5The Feinstein Institute for Medical Research, Manhasset, New York
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Kejin Wu
1Department of Surgical Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing; Departments of 2General Surgery and 3Pathology, XinHua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China; 4Centre for Bioinformatics, School of Life Science, Pondicherry University, Puducherry, India; and 5The Feinstein Institute for Medical Research, Manhasset, New York
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Bo Zhang
1Department of Surgical Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing; Departments of 2General Surgery and 3Pathology, XinHua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China; 4Centre for Bioinformatics, School of Life Science, Pondicherry University, Puducherry, India; and 5The Feinstein Institute for Medical Research, Manhasset, New York
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Ziyi Weng
1Department of Surgical Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing; Departments of 2General Surgery and 3Pathology, XinHua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China; 4Centre for Bioinformatics, School of Life Science, Pondicherry University, Puducherry, India; and 5The Feinstein Institute for Medical Research, Manhasset, New York
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Mingjie Zhu
1Department of Surgical Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing; Departments of 2General Surgery and 3Pathology, XinHua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China; 4Centre for Bioinformatics, School of Life Science, Pondicherry University, Puducherry, India; and 5The Feinstein Institute for Medical Research, Manhasset, New York
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Yunshu Lu
1Department of Surgical Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing; Departments of 2General Surgery and 3Pathology, XinHua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China; 4Centre for Bioinformatics, School of Life Science, Pondicherry University, Puducherry, India; and 5The Feinstein Institute for Medical Research, Manhasset, New York
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Ramadas Krishna
1Department of Surgical Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing; Departments of 2General Surgery and 3Pathology, XinHua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China; 4Centre for Bioinformatics, School of Life Science, Pondicherry University, Puducherry, India; and 5The Feinstein Institute for Medical Research, Manhasset, New York
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Yuenian Eric Shi
1Department of Surgical Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing; Departments of 2General Surgery and 3Pathology, XinHua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China; 4Centre for Bioinformatics, School of Life Science, Pondicherry University, Puducherry, India; and 5The Feinstein Institute for Medical Research, Manhasset, New York
1Department of Surgical Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing; Departments of 2General Surgery and 3Pathology, XinHua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China; 4Centre for Bioinformatics, School of Life Science, Pondicherry University, Puducherry, India; and 5The Feinstein Institute for Medical Research, Manhasset, New York
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DOI: 10.1158/1535-7163.MCT-13-0671 Published March 2014
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Total218917981986

Cited By

Article Information

Volume 13, Issue 3, pp. 699-713

DOI 
https://doi.org/10.1158/1535-7163.MCT-13-0671
PubMed 
24431077

Published By 
American Association for Cancer Research
Print ISSN 
1535-7163
Online ISSN 
1538-8514
History 
  • Received August 14, 2013
  • Revision received December 11, 2013
  • Accepted December 26, 2013
  • Published first January 15, 2014.

Article Versions

  • Previous version (January 15, 2014 - 11:18).
  • Previous version (February 24, 2014 - 13:51).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2014 American Association for Cancer Research.

Author Information

  1. Suyu Miao1,
  2. Kejin Wu2,
  3. Bo Zhang1,
  4. Ziyi Weng2,
  5. Mingjie Zhu3,
  6. Yunshu Lu2,
  7. Ramadas Krishna4, and
  8. Yuenian Eric Shi1,5
  1. Authors' Affiliations: 1Department of Surgical Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing; Departments of 2General Surgery and 3Pathology, XinHua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China; 4Centre for Bioinformatics, School of Life Science, Pondicherry University, Puducherry, India; and 5The Feinstein Institute for Medical Research, Manhasset, New York
  1. Corresponding Authors:
    Yuenian Eric Shi, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, China. E-mail: daweieric{at}gmail.com; and Kejin Wu, Department of General Surgery, XinHua Hospital, Shanghai Jiaotong University School of Medicine, 1665 Kongjiang Road, Shanghai, 200092. E-mail: kejinwu{at}163.com.
  1. S. Miao and K. Wu contributed equally to this work.

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Molecular Cancer Therapeutics: 13 (3)
March 2014
Volume 13, Issue 3
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Synuclein γ Compromises Spindle Assembly Checkpoint and Renders Resistance to Antimicrotubule Drugs
Suyu Miao, Kejin Wu, Bo Zhang, Ziyi Weng, Mingjie Zhu, Yunshu Lu, Ramadas Krishna and Yuenian Eric Shi
Mol Cancer Ther March 1 2014 (13) (3) 699-713; DOI: 10.1158/1535-7163.MCT-13-0671

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Synuclein γ Compromises Spindle Assembly Checkpoint and Renders Resistance to Antimicrotubule Drugs
Suyu Miao, Kejin Wu, Bo Zhang, Ziyi Weng, Mingjie Zhu, Yunshu Lu, Ramadas Krishna and Yuenian Eric Shi
Mol Cancer Ther March 1 2014 (13) (3) 699-713; DOI: 10.1158/1535-7163.MCT-13-0671
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