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Molecular Cancer Therapeutics
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Small Molecule Therapeutics

Disruption of STAT3 by Niclosamide Reverses Radioresistance of Human Lung Cancer

Shuo You, Rui Li, Dongkyoo Park, Maohua Xie, Gabriel L. Sica, Ya Cao, Zhi-Qiang Xiao and Xingming Deng
Shuo You
Departments of 1Radiation Oncology and 2Pathology, Emory University School of Medicine and Winship Cancer Institute of Emory University, Atlanta, Georgia; 3Cancer Research Institute; 4Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, Xiangya Hospital; 5The Second Affiliated Hospital of Xiangya, Central South University, Changsha, Hunan, China
Departments of 1Radiation Oncology and 2Pathology, Emory University School of Medicine and Winship Cancer Institute of Emory University, Atlanta, Georgia; 3Cancer Research Institute; 4Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, Xiangya Hospital; 5The Second Affiliated Hospital of Xiangya, Central South University, Changsha, Hunan, China
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Rui Li
Departments of 1Radiation Oncology and 2Pathology, Emory University School of Medicine and Winship Cancer Institute of Emory University, Atlanta, Georgia; 3Cancer Research Institute; 4Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, Xiangya Hospital; 5The Second Affiliated Hospital of Xiangya, Central South University, Changsha, Hunan, China
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Dongkyoo Park
Departments of 1Radiation Oncology and 2Pathology, Emory University School of Medicine and Winship Cancer Institute of Emory University, Atlanta, Georgia; 3Cancer Research Institute; 4Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, Xiangya Hospital; 5The Second Affiliated Hospital of Xiangya, Central South University, Changsha, Hunan, China
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Maohua Xie
Departments of 1Radiation Oncology and 2Pathology, Emory University School of Medicine and Winship Cancer Institute of Emory University, Atlanta, Georgia; 3Cancer Research Institute; 4Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, Xiangya Hospital; 5The Second Affiliated Hospital of Xiangya, Central South University, Changsha, Hunan, China
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Gabriel L. Sica
Departments of 1Radiation Oncology and 2Pathology, Emory University School of Medicine and Winship Cancer Institute of Emory University, Atlanta, Georgia; 3Cancer Research Institute; 4Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, Xiangya Hospital; 5The Second Affiliated Hospital of Xiangya, Central South University, Changsha, Hunan, China
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Ya Cao
Departments of 1Radiation Oncology and 2Pathology, Emory University School of Medicine and Winship Cancer Institute of Emory University, Atlanta, Georgia; 3Cancer Research Institute; 4Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, Xiangya Hospital; 5The Second Affiliated Hospital of Xiangya, Central South University, Changsha, Hunan, China
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Zhi-Qiang Xiao
Departments of 1Radiation Oncology and 2Pathology, Emory University School of Medicine and Winship Cancer Institute of Emory University, Atlanta, Georgia; 3Cancer Research Institute; 4Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, Xiangya Hospital; 5The Second Affiliated Hospital of Xiangya, Central South University, Changsha, Hunan, China
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Xingming Deng
Departments of 1Radiation Oncology and 2Pathology, Emory University School of Medicine and Winship Cancer Institute of Emory University, Atlanta, Georgia; 3Cancer Research Institute; 4Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, Xiangya Hospital; 5The Second Affiliated Hospital of Xiangya, Central South University, Changsha, Hunan, China
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DOI: 10.1158/1535-7163.MCT-13-0608 Published March 2014
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ARTICLE USAGE: December 2013 to January 2021

AbstractFull-text HTMLPDF
Total314919582116

Cited By

Article Information

Volume 13, Issue 3, pp. 606-616

DOI 
https://doi.org/10.1158/1535-7163.MCT-13-0608
PubMed 
24362463

Published By 
American Association for Cancer Research
Print ISSN 
1535-7163
Online ISSN 
1538-8514
History 
  • Received July 29, 2013
  • Revision received November 19, 2013
  • Accepted December 4, 2013
  • Published first December 20, 2013.

Article Versions

  • Previous version (December 20, 2013 - 07:59).
  • Previous version (February 21, 2014 - 12:32).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2013 American Association for Cancer Research.

Author Information

  1. Shuo You1,5,
  2. Rui Li1,
  3. Dongkyoo Park1,
  4. Maohua Xie1,
  5. Gabriel L. Sica2,
  6. Ya Cao3,
  7. Zhi-Qiang Xiao4, and
  8. Xingming Deng1
  1. Authors' Affiliations: Departments of 1Radiation Oncology and 2Pathology, Emory University School of Medicine and Winship Cancer Institute of Emory University, Atlanta, Georgia; 3Cancer Research Institute; 4Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, Xiangya Hospital; 5The Second Affiliated Hospital of Xiangya, Central South University, Changsha, Hunan, China
  1. Corresponding Authors:
    Xingming Deng, Division of Cancer Biology, Department of Radiation Oncology, Emory University School of Medicine and Winship Cancer Institute of Emory University, Atlanta, GA 30322. Phone: 404-778-3398; Fax: 404-778-5530; E-mail: xdeng4{at}emory.edu; Zhi-Qiang Xiao, Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha, Hunan, China. Phone: 86-138-731-46236; Fax: 86-731-8432-7332; E-mail: zqxiao2001{at}hotmail.com
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Molecular Cancer Therapeutics: 13 (3)
March 2014
Volume 13, Issue 3
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Disruption of STAT3 by Niclosamide Reverses Radioresistance of Human Lung Cancer
Shuo You, Rui Li, Dongkyoo Park, Maohua Xie, Gabriel L. Sica, Ya Cao, Zhi-Qiang Xiao and Xingming Deng
Mol Cancer Ther March 1 2014 (13) (3) 606-616; DOI: 10.1158/1535-7163.MCT-13-0608

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Disruption of STAT3 by Niclosamide Reverses Radioresistance of Human Lung Cancer
Shuo You, Rui Li, Dongkyoo Park, Maohua Xie, Gabriel L. Sica, Ya Cao, Zhi-Qiang Xiao and Xingming Deng
Mol Cancer Ther March 1 2014 (13) (3) 606-616; DOI: 10.1158/1535-7163.MCT-13-0608
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