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Molecular Cancer Therapeutics
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Small Molecule Therapeutics

A Novel Small-Molecule Inhibitor of Mcl-1 Blocks Pancreatic Cancer Growth In Vitro and In Vivo

Fardokht Abulwerdi, Chenzhong Liao, Meilan Liu, Asfar S. Azmi, Amro Aboukameel, Ahmed S.A. Mady, Thippeswamy Gulappa, Tomasz Cierpicki, Scott Owens, Tao Zhang, Duxin Sun, Jeanne A. Stuckey, Ramzi M. Mohammad and Zaneta Nikolovska-Coleska
Fardokht Abulwerdi
1Department of Pathology, University of Michigan Medical School; 2Interdepartmental Program in Medicinal Chemistry, 3Life Sciences Institute; 4Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan; and 5Karmanos Cancer Institute, Wayne State University, Detroit, Michigan
1Department of Pathology, University of Michigan Medical School; 2Interdepartmental Program in Medicinal Chemistry, 3Life Sciences Institute; 4Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan; and 5Karmanos Cancer Institute, Wayne State University, Detroit, Michigan
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Chenzhong Liao
1Department of Pathology, University of Michigan Medical School; 2Interdepartmental Program in Medicinal Chemistry, 3Life Sciences Institute; 4Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan; and 5Karmanos Cancer Institute, Wayne State University, Detroit, Michigan
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Meilan Liu
1Department of Pathology, University of Michigan Medical School; 2Interdepartmental Program in Medicinal Chemistry, 3Life Sciences Institute; 4Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan; and 5Karmanos Cancer Institute, Wayne State University, Detroit, Michigan
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Asfar S. Azmi
1Department of Pathology, University of Michigan Medical School; 2Interdepartmental Program in Medicinal Chemistry, 3Life Sciences Institute; 4Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan; and 5Karmanos Cancer Institute, Wayne State University, Detroit, Michigan
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Amro Aboukameel
1Department of Pathology, University of Michigan Medical School; 2Interdepartmental Program in Medicinal Chemistry, 3Life Sciences Institute; 4Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan; and 5Karmanos Cancer Institute, Wayne State University, Detroit, Michigan
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Ahmed S.A. Mady
1Department of Pathology, University of Michigan Medical School; 2Interdepartmental Program in Medicinal Chemistry, 3Life Sciences Institute; 4Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan; and 5Karmanos Cancer Institute, Wayne State University, Detroit, Michigan
1Department of Pathology, University of Michigan Medical School; 2Interdepartmental Program in Medicinal Chemistry, 3Life Sciences Institute; 4Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan; and 5Karmanos Cancer Institute, Wayne State University, Detroit, Michigan
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Thippeswamy Gulappa
1Department of Pathology, University of Michigan Medical School; 2Interdepartmental Program in Medicinal Chemistry, 3Life Sciences Institute; 4Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan; and 5Karmanos Cancer Institute, Wayne State University, Detroit, Michigan
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Tomasz Cierpicki
1Department of Pathology, University of Michigan Medical School; 2Interdepartmental Program in Medicinal Chemistry, 3Life Sciences Institute; 4Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan; and 5Karmanos Cancer Institute, Wayne State University, Detroit, Michigan
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Scott Owens
1Department of Pathology, University of Michigan Medical School; 2Interdepartmental Program in Medicinal Chemistry, 3Life Sciences Institute; 4Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan; and 5Karmanos Cancer Institute, Wayne State University, Detroit, Michigan
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Tao Zhang
1Department of Pathology, University of Michigan Medical School; 2Interdepartmental Program in Medicinal Chemistry, 3Life Sciences Institute; 4Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan; and 5Karmanos Cancer Institute, Wayne State University, Detroit, Michigan
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Duxin Sun
1Department of Pathology, University of Michigan Medical School; 2Interdepartmental Program in Medicinal Chemistry, 3Life Sciences Institute; 4Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan; and 5Karmanos Cancer Institute, Wayne State University, Detroit, Michigan
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Jeanne A. Stuckey
1Department of Pathology, University of Michigan Medical School; 2Interdepartmental Program in Medicinal Chemistry, 3Life Sciences Institute; 4Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan; and 5Karmanos Cancer Institute, Wayne State University, Detroit, Michigan
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Ramzi M. Mohammad
1Department of Pathology, University of Michigan Medical School; 2Interdepartmental Program in Medicinal Chemistry, 3Life Sciences Institute; 4Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan; and 5Karmanos Cancer Institute, Wayne State University, Detroit, Michigan
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Zaneta Nikolovska-Coleska
1Department of Pathology, University of Michigan Medical School; 2Interdepartmental Program in Medicinal Chemistry, 3Life Sciences Institute; 4Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan; and 5Karmanos Cancer Institute, Wayne State University, Detroit, Michigan
1Department of Pathology, University of Michigan Medical School; 2Interdepartmental Program in Medicinal Chemistry, 3Life Sciences Institute; 4Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan; and 5Karmanos Cancer Institute, Wayne State University, Detroit, Michigan
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DOI: 10.1158/1535-7163.MCT-12-0767 Published March 2014
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ARTICLE USAGE: September 2013 to April 2021

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Article Information

Volume 13, Issue 3, pp. 565-575

DOI 
https://doi.org/10.1158/1535-7163.MCT-12-0767
PubMed 
24019208

Published By 
American Association for Cancer Research
Print ISSN 
1535-7163
Online ISSN 
1538-8514
History 
  • Received July 23, 2012
  • Revision received August 19, 2013
  • Accepted August 24, 2013
  • Published first September 9, 2013.

Article Versions

  • Previous version (September 9, 2013 - 12:01).
  • Previous version (February 24, 2014 - 14:25).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2013 American Association for Cancer Research.

Author Information

  1. Fardokht Abulwerdi1,2,
  2. Chenzhong Liao1,
  3. Meilan Liu1,
  4. Asfar S. Azmi5,
  5. Amro Aboukameel5,
  6. Ahmed S.A. Mady1,2,
  7. Thippeswamy Gulappa1,
  8. Tomasz Cierpicki1,
  9. Scott Owens1,
  10. Tao Zhang4,
  11. Duxin Sun4,
  12. Jeanne A. Stuckey3,
  13. Ramzi M. Mohammad5, and
  14. Zaneta Nikolovska-Coleska1,2
  1. Authors' Affiliations: 1Department of Pathology, University of Michigan Medical School; 2Interdepartmental Program in Medicinal Chemistry, 3Life Sciences Institute; 4Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan; and 5Karmanos Cancer Institute, Wayne State University, Detroit, Michigan
  1. Corresponding Author:
    Zaneta Nikolovska-Coleska, 4510E MSRB I, 1150 West Medical Center Drive, Ann Arbor, MI 48109. Phone: 734-615-9202; Fax: 734-763-6476; E-mail: zanetan{at}med.umich.edu
  1. F. Abulwerdi and C. Liao contributed equally to this work.

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Molecular Cancer Therapeutics: 13 (3)
March 2014
Volume 13, Issue 3
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A Novel Small-Molecule Inhibitor of Mcl-1 Blocks Pancreatic Cancer Growth In Vitro and In Vivo
Fardokht Abulwerdi, Chenzhong Liao, Meilan Liu, Asfar S. Azmi, Amro Aboukameel, Ahmed S.A. Mady, Thippeswamy Gulappa, Tomasz Cierpicki, Scott Owens, Tao Zhang, Duxin Sun, Jeanne A. Stuckey, Ramzi M. Mohammad and Zaneta Nikolovska-Coleska
Mol Cancer Ther March 1 2014 (13) (3) 565-575; DOI: 10.1158/1535-7163.MCT-12-0767

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A Novel Small-Molecule Inhibitor of Mcl-1 Blocks Pancreatic Cancer Growth In Vitro and In Vivo
Fardokht Abulwerdi, Chenzhong Liao, Meilan Liu, Asfar S. Azmi, Amro Aboukameel, Ahmed S.A. Mady, Thippeswamy Gulappa, Tomasz Cierpicki, Scott Owens, Tao Zhang, Duxin Sun, Jeanne A. Stuckey, Ramzi M. Mohammad and Zaneta Nikolovska-Coleska
Mol Cancer Ther March 1 2014 (13) (3) 565-575; DOI: 10.1158/1535-7163.MCT-12-0767
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