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Molecular Cancer Therapeutics
Molecular Cancer Therapeutics
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Cancer Biology and Signal Transduction

GSK3 Inhibitors Regulate MYCN mRNA Levels and Reduce Neuroblastoma Cell Viability through Multiple Mechanisms, Including p53 and Wnt Signaling

David J. Duffy, Aleksandar Krstic, Thomas Schwarzl, Desmond G. Higgins and Walter Kolch
David J. Duffy
1Systems Biology Ireland; 2Conway Institute of Biomolecular and Biomedical Research; and 3School of Medicine and Medical Science, University College Dublin, Belfield, Dublin, Ireland
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Aleksandar Krstic
1Systems Biology Ireland; 2Conway Institute of Biomolecular and Biomedical Research; and 3School of Medicine and Medical Science, University College Dublin, Belfield, Dublin, Ireland
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Thomas Schwarzl
1Systems Biology Ireland; 2Conway Institute of Biomolecular and Biomedical Research; and 3School of Medicine and Medical Science, University College Dublin, Belfield, Dublin, Ireland
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Desmond G. Higgins
1Systems Biology Ireland; 2Conway Institute of Biomolecular and Biomedical Research; and 3School of Medicine and Medical Science, University College Dublin, Belfield, Dublin, Ireland
1Systems Biology Ireland; 2Conway Institute of Biomolecular and Biomedical Research; and 3School of Medicine and Medical Science, University College Dublin, Belfield, Dublin, Ireland
1Systems Biology Ireland; 2Conway Institute of Biomolecular and Biomedical Research; and 3School of Medicine and Medical Science, University College Dublin, Belfield, Dublin, Ireland
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Walter Kolch
1Systems Biology Ireland; 2Conway Institute of Biomolecular and Biomedical Research; and 3School of Medicine and Medical Science, University College Dublin, Belfield, Dublin, Ireland
1Systems Biology Ireland; 2Conway Institute of Biomolecular and Biomedical Research; and 3School of Medicine and Medical Science, University College Dublin, Belfield, Dublin, Ireland
1Systems Biology Ireland; 2Conway Institute of Biomolecular and Biomedical Research; and 3School of Medicine and Medical Science, University College Dublin, Belfield, Dublin, Ireland
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DOI: 10.1158/1535-7163.MCT-13-0560-T Published February 2014
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ARTICLE USAGE: November 2013 to March 2021

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Total342839323205

Cited By

Article Information

Volume 13, Issue 2, pp. 454-467

DOI 
https://doi.org/10.1158/1535-7163.MCT-13-0560-T
PubMed 
24282277

Published By 
American Association for Cancer Research
Print ISSN 
1535-7163
Online ISSN 
1538-8514
History 
  • Received July 17, 2013
  • Revision received November 4, 2013
  • Accepted November 18, 2013
  • Published first November 26, 2013.

Article Versions

  • Previous version (November 26, 2013 - 13:00).
  • Previous version (January 22, 2014 - 12:45).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2013 American Association for Cancer Research.

Author Information

  1. David J. Duffy1,
  2. Aleksandar Krstic1,
  3. Thomas Schwarzl1,
  4. Desmond G. Higgins1,2,3, and
  5. Walter Kolch1,2,3
  1. Authors' Affiliations: 1Systems Biology Ireland; 2Conway Institute of Biomolecular and Biomedical Research; and 3School of Medicine and Medical Science, University College Dublin, Belfield, Dublin, Ireland
  1. Corresponding Author:
    David J. Duffy, University College Dublin, Belfield, Dublin 4, Ireland. Fax: 353-1-716-6701; E-mail: david.duffy{at}ucd.ie
  1. A. Krstic and T. Schwarzl contributed equally to this work.

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Molecular Cancer Therapeutics: 13 (2)
February 2014
Volume 13, Issue 2
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GSK3 Inhibitors Regulate MYCN mRNA Levels and Reduce Neuroblastoma Cell Viability through Multiple Mechanisms, Including p53 and Wnt Signaling
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GSK3 Inhibitors Regulate MYCN mRNA Levels and Reduce Neuroblastoma Cell Viability through Multiple Mechanisms, Including p53 and Wnt Signaling
David J. Duffy, Aleksandar Krstic, Thomas Schwarzl, Desmond G. Higgins and Walter Kolch
Mol Cancer Ther February 1 2014 (13) (2) 454-467; DOI: 10.1158/1535-7163.MCT-13-0560-T

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GSK3 Inhibitors Regulate MYCN mRNA Levels and Reduce Neuroblastoma Cell Viability through Multiple Mechanisms, Including p53 and Wnt Signaling
David J. Duffy, Aleksandar Krstic, Thomas Schwarzl, Desmond G. Higgins and Walter Kolch
Mol Cancer Ther February 1 2014 (13) (2) 454-467; DOI: 10.1158/1535-7163.MCT-13-0560-T
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Molecular Cancer Therapeutics
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