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Molecular Cancer Therapeutics
Molecular Cancer Therapeutics
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About the Cover

Cover image

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Zebrafish embryos can be used to examine mechanisms of vascular development and as a platform with which to identify novel antivascular agents; this is an image of a 2-day-old zebrafish embryo showing developing lymphatic vessels in green (lyve1:egfp) and endothelial cell nuclei in red (kdrl:nls:mcherry). This embryo was live imaged for a further 20 hours to identify novel inhibitors of lymphatic vessel growth and revealed that flunarizine, a calcium channel antagonist, was able specifically induce lymphatic endothelial cell death. For details, see the article by Astin and colleagues on page 2450.

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Molecular Cancer Therapeutics: 13 (10)
October 2014
Volume 13, Issue 10
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Issue Highlights

  • An In Vivo Antilymphatic Screen in Zebrafish Identifies Novel Inhibitors of Mammalian Lymphangiogenesis and Lymphatic-Mediated Metastasis
  • Redirected T-Cell Killing of Solid Cancers Targeted with an Anti-CD3/Trop-2–Bispecific Antibody Is Enhanced in Combination with Interferon-α
  • The CDK4/6 Inhibitor LY2835219 Overcomes Vemurafenib Resistance Resulting from MAPK Reactivation and Cyclin D1 Upregulation
  • Inhibition of Endoglin–GIPC Interaction Inhibits Pancreatic Cancer Cell Growth
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Molecular Cancer Therapeutics
eISSN: 1538-8514
ISSN: 1535-7163

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