Molecular Cancer Therapeutics: 13 (10)

Highlights

Highlights

Highlights of This Issue

Mol Cancer Ther October 1 2014 13 (10) 2251-2251;

Small Molecule Therapeutics

Small Molecule Therapeutics

The CDK4/6 Inhibitor LY2835219 Overcomes Vemurafenib Resistance Resulting from MAPK Reactivation and Cyclin D1 Upregulation

Vipin Yadav, Teresa F. Burke, Lysiane Huber, Robert D. Van Horn, Youyan Zhang, Sean G. Buchanan, Edward M. Chan, James J. Starling, Richard P. Beckmann and Sheng-Bin Peng

Mol Cancer Ther October 1 2014 13 (10) 2253-2263; DOI:10.1158/1535-7163.MCT-14-0257
Small Molecule Therapeutics

Inhibition of Endoglin–GIPC Interaction Inhibits Pancreatic Cancer Cell Growth

Krishnendu Pal, Alexandre A. Pletnev, Shamit K. Dutta, Enfeng Wang, Ruizhi Zhao, Aradhita Baral, Vinod Kumar Yadav, Suruchi Aggarwal, Soundararajan Krishnaswamy, Khalid M. Alkharfy, Shantanu Chowdhury, Mark R. Spaller and Debabrata Mukhopadhyay

Mol Cancer Ther October 1 2014 13 (10) 2264-2275; DOI:10.1158/1535-7163.MCT-14-0291
Small Molecule Therapeutics | AuthorChoice

Drug Repurposing Identifies a Synergistic Combination Therapy with Imatinib Mesylate for Gastrointestinal Stromal Tumor

Ziyan Y. Pessetto, Yan Ma, Jeff J. Hirst, Margaret von Mehren, Scott J. Weir and Andrew K. Godwin

Mol Cancer Ther October 1 2014 13 (10) 2276-2287; DOI:10.1158/1535-7163.MCT-14-0043
Small Molecule Therapeutics

Synergistic Simvastatin and Metformin Combination Chemotherapy for Osseous Metastatic Castration-Resistant Prostate Cancer

Melissa A. Babcook, Sanjeev Shukla, Pingfu Fu, Edwin J. Vazquez, Michelle A. Puchowicz, Joseph P. Molter, Christine Z. Oak, Gregory T. MacLennan, Chris A. Flask, Daniel J. Lindner, Yvonne Parker, Firouz Daneshgari and Sanjay Gupta

Mol Cancer Ther October 1 2014 13 (10) 2288-2302; DOI:10.1158/1535-7163.MCT-14-0451
Small Molecule Therapeutics

The CREB-Binding Protein Inhibitor ICG-001 Suppresses Pancreatic Cancer Growth

Michael D. Arensman, Donatello Telesca, Anna R. Lay, Kathleen M. Kershaw, Nanping Wu, Timothy R. Donahue and David W. Dawson

Mol Cancer Ther October 1 2014 13 (10) 2303-2314; DOI:10.1158/1535-7163.MCT-13-1005
Small Molecule Therapeutics

BET Protein Antagonist JQ1 Is Synergistically Lethal with FLT3 Tyrosine Kinase Inhibitor (TKI) and Overcomes Resistance to FLT3-TKI in AML Cells Expressing FLT-ITD

Warren Fiskus, Sunil Sharma, Jun Qi, Bhavin Shah, Santhana G.T. Devaraj, Christopher Leveque, Bryce P. Portier, Swaminathan Iyer, James E. Bradner and Kapil N. Bhalla

Mol Cancer Ther October 1 2014 13 (10) 2315-2327; DOI:10.1158/1535-7163.MCT-14-0258
Small Molecule Therapeutics

Nanolipolee-007, a Novel Nanoparticle-Based Drug Containing Leelamine for the Treatment of Melanoma

Raghavendra Gowda, SubbaRao V. Madhunapantula, Arati Sharma, Omer F. Kuzu and Gavin P. Robertson

Mol Cancer Ther October 1 2014 13 (10) 2328-2340; DOI:10.1158/1535-7163.MCT-14-0357

Large Molecule Therapeutics

Large Molecule Therapeutics

Redirected T-Cell Killing of Solid Cancers Targeted with an Anti-CD3/Trop-2–Bispecific Antibody Is Enhanced in Combination with Interferon-α

Edmund A. Rossi, Diane L. Rossi, Thomas M. Cardillo, Chien-Hsing Chang and David M. Goldenberg

Mol Cancer Ther October 1 2014 13 (10) 2341-2351; DOI:10.1158/1535-7163.MCT-14-0345
Large Molecule Therapeutics

Systemic Delivery of a miR34a Mimic as a Potential Therapeutic for Liver Cancer

Christopher L. Daige, Jason F. Wiggins, Leslie Priddy, Terri Nelligan-Davis, Jane Zhao and David Brown

Mol Cancer Ther October 1 2014 13 (10) 2352-2360; DOI:10.1158/1535-7163.MCT-14-0209

Cancer Biology and Signal Transduction

Cancer Biology and Signal Transduction

Lipid Catabolism via CPT1 as a Therapeutic Target for Prostate Cancer

Isabel R. Schlaepfer, Leah Rider, Lindsey Ulkus Rodrigues, Miguel A. Gijón, Colton T. Pac, Lina Romero, Adela Cimic, S. Joseph Sirintrapun, L. Michael Glodé, Robert H. Eckel and Scott D. Cramer

Mol Cancer Ther October 1 2014 13 (10) 2361-2371; DOI:10.1158/1535-7163.MCT-14-0183
Cancer Biology and Signal Transduction

Prostate Cancer Cell Response to Paclitaxel Is Affected by Abnormally Expressed Securin PTTG1

Carolina Castilla, M. Luz Flores, Rafael Medina, Begoña Pérez-Valderrama, Francisco Romero, María Tortolero, Miguel A. Japón and Carmen Sáez

Mol Cancer Ther October 1 2014 13 (10) 2372-2383; DOI:10.1158/1535-7163.MCT-13-0405
Cancer Biology and Signal Transduction

Regulation of OSU-03012 Toxicity by ER Stress Proteins and ER Stress–Inducing Drugs

Laurence Booth, Jane L. Roberts, Nichola Cruickshanks, Steven Grant, Andrew Poklepovic and Paul Dent

Mol Cancer Ther October 1 2014 13 (10) 2384-2398; DOI:10.1158/1535-7163.MCT-14-0172
Cancer Biology and Signal Transduction

Temozolomide Induces the Production of Epidermal Growth Factor to Regulate MDR1 Expression in Glioblastoma Cells

Jessian L. Munoz, Vivian Rodriguez-Cruz, Steven J. Greco, Vipul Nagula, Kathleen W. Scotto and Pranela Rameshwar

Mol Cancer Ther October 1 2014 13 (10) 2399-2411; DOI:10.1158/1535-7163.MCT-14-0011
Cancer Biology and Signal Transduction | AuthorChoice

BRCA2 and RAD51 Promote Double-Strand Break Formation and Cell Death in Response to Gemcitabine

Rebecca M. Jones, Panagiotis Kotsantis, Grant S. Stewart, Petra Groth and Eva Petermann

Mol Cancer Ther October 1 2014 13 (10) 2412-2421; DOI:10.1158/1535-7163.MCT-13-0862
Cancer Biology and Signal Transduction

Piperlongumine Chemosensitizes Tumor Cells through Interaction with Cysteine 179 of IκBα Kinase, Leading to Suppression of NF-κB–Regulated Gene Products

Jia Gang Han, Subash C. Gupta, Sahdeo Prasad and Bharat B. Aggarwal

Mol Cancer Ther October 1 2014 13 (10) 2422-2435; DOI:10.1158/1535-7163.MCT-14-0171
Cancer Biology and Signal Transduction

Calpain-Mediated Integrin Deregulation as a Novel Mode of Action for the Anticancer Gallium Compound KP46

Ute Jungwirth, Johannes Gojo, Theresa Tuder, Gernot Walko, Martin Holcmann, Thomas Schöfl, Karin Nowikovsky, Nastasia Wilfinger, Sushilla Schoonhoven, Christian R. Kowol, Rosa Lemmens-Gruber, Petra Heffeter, Bernhard K. Keppler and Walter Berger

Mol Cancer Ther October 1 2014 13 (10) 2436-2449; DOI:10.1158/1535-7163.MCT-14-0087

Models and Technologies

Models and Technologies

An In Vivo Antilymphatic Screen in Zebrafish Identifies Novel Inhibitors of Mammalian Lymphangiogenesis and Lymphatic-Mediated Metastasis

Jonathan W. Astin, Stephen M.F. Jamieson, Tiffany C.Y. Eng, Maria V. Flores, June P. Misa, Annie Chien, Kathryn E. Crosier and Philip S. Crosier

Mol Cancer Ther October 1 2014 13 (10) 2450-2462; DOI:10.1158/1535-7163.MCT-14-0469-T
Models and Technologies

Integrated Analysis of Transcriptomes of Cancer Cell Lines and Patient Samples Reveals STK11/LKB1–Driven Regulation of cAMP Phosphodiesterase-4D

Ningning He, Nayoung Kim, Mee Song, Choa Park, Somin Kim, Eun Young Park, Hwa Young Yim, Kyunga Kim, Jong Hoon Park, Keun Il Kim, Fan Zhang, Gordon B. Mills and Sukjoon Yoon

Mol Cancer Ther October 1 2014 13 (10) 2463-2473; DOI:10.1158/1535-7163.MCT-14-0297

Main menu

User menu

Search

Table of Contents

Highlights

Small Molecule Therapeutics

Large Molecule Therapeutics

Cancer Biology and Signal Transduction

Models and Technologies

Issue Highlights

Jump to

Articles

Info for

About MCT