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Molecular Cancer Therapeutics
Molecular Cancer Therapeutics
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About the Cover

Cover image

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TRAIL is a potent inductor of apoptosis through activation of death receptors expressed on tumor cells. To improve the therapeutic activity of TRAIL, a novel tetravalent, bifunctional fusion protein was generated composed of single-chain Fv for targeted delivery (shown in blue), the IgE heavy chain domain 2 (EHD2) as covalently linked homodimerization module (shown in green), and a single-chain derivative of TRAIL as effector moiety (shown in red). Potent antitumoral effects were demonstrated for this scFv-EHD2-scTRAIL fusion protein in vitro and in vivo, further establishing the advantages of combining tumor targeting with dimeric presentation of scTRAIL. For details, see article by Seifert and colleagues on page 101.

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Molecular Cancer Therapeutics: 13 (1)
January 2014
Volume 13, Issue 1
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Issue Highlights

  • Tetravalent Antibody–scTRAIL Fusion Proteins with Improved Properties
  • Synergistic Combination of Novel Tubulin Inhibitor ABI-274 and Vemurafenib Overcomes Vemurafenib Acquired Resistance in BRAFV600E Melanoma
  • Enhanced PI3K p110α Signaling Confers Acquired Lapatinib Resistance That Can Be Effectively Reversed by a p110α-Selective PI3K Inhibitor
  • Superior Antitumor Activity of a Novel Bispecific Antibody Cotargeting Human Epidermal Growth Factor Receptor 2 and Type I Insulin-like Growth Factor Receptor
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Molecular Cancer Therapeutics
eISSN: 1538-8514
ISSN: 1535-7163

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