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Molecular Cancer Therapeutics
Molecular Cancer Therapeutics
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Table of Contents

Highlights

  • Highlights
    Highlights of This Issue
    Mol Cancer Ther January 1 2014 13 (1) 1-1;

Editorial

  • Editorial
    A Message from the New Editor-in-Chief
    Napoleone Ferrara
    Mol Cancer Ther January 1 2014 13 (1) 3-4; DOI:10.1158/1535-7163.MCT-13-1077

Small Molecule Therapeutics

  • Small Molecule Therapeutics
    Small-Molecule IAP Antagonists Sensitize Cancer Cells to TRAIL-Induced Apoptosis: Roles of XIAP and cIAPs
    Darren Finlay, Mitchell Vamos, Marcos González-López, Robert J. Ardecky, Santhi Reddy Ganji, Hongbin Yuan, Ying Su, Trina R. Cooley, Curt T. Hauser, Kate Welsh, John C. Reed, Nicholas D.P. Cosford and Kristiina Vuori
    Mol Cancer Ther January 1 2014 13 (1) 5-15; DOI:10.1158/1535-7163.MCT-13-0153

  • Small Molecule Therapeutics
    Synergistic Combination of Novel Tubulin Inhibitor ABI-274 and Vemurafenib Overcomes Vemurafenib Acquired Resistance in BRAFV600E Melanoma
    Jin Wang, Jianjun Chen, Duane D. Miller and Wei Li
    Mol Cancer Ther January 1 2014 13 (1) 16-26; DOI:10.1158/1535-7163.MCT-13-0212

  • Small Molecule Therapeutics
    SC-60, a Dimer-Based Sorafenib Derivative, Shows a Better Anti–Hepatocellular Carcinoma Effect than Sorafenib in a Preclinical Hepatocellular Carcinoma Model
    Wei-Tien Tai, Chung-Wai Shiau, Yong-Shi Li, Yao-Li Chen, Pei-Yi Chu, Jui-Wen Huang, Cheng-Yi Hsu, Yi-Chieh Hsu, Pei-Jer Chen and Kuen-Feng Chen
    Mol Cancer Ther January 1 2014 13 (1) 27-36; DOI:10.1158/1535-7163.MCT-13-0595

  • Small Molecule Therapeutics
    Synergistic Activities of MET/RON Inhibitor BMS-777607 and mTOR Inhibitor AZD8055 to Polyploid Cells Derived from Pancreatic Cancer and Cancer Stem Cells
    Jun-Ying Zeng, Sharad Sharma, Yong-Qing Zhou, Hang-Ping Yao, Xing Hu, Ruiwen Zhang and Ming-Hai Wang
    Mol Cancer Ther January 1 2014 13 (1) 37-48; DOI:10.1158/1535-7163.MCT-13-0242

  • Small Molecule Therapeutics
    Lappaol F, a Novel Anticancer Agent Isolated from Plant Arctium Lappa L.
    Qing Sun, Kanglun Liu, Xiaoling Shen, Weixin Jin, Lingyan Jiang, M. Saeed Sheikh, Yingjie Hu and Ying Huang
    Mol Cancer Ther January 1 2014 13 (1) 49-59; DOI:10.1158/1535-7163.MCT-13-0552

  • Small Molecule Therapeutics
    Enhanced PI3K p110α Signaling Confers Acquired Lapatinib Resistance That Can Be Effectively Reversed by a p110α-Selective PI3K Inhibitor
    Samuel W. Brady, Jian Zhang, Daniel Seok, Hai Wang and Dihua Yu
    Mol Cancer Ther January 1 2014 13 (1) 60-70; DOI:10.1158/1535-7163.MCT-13-0518

Large Molecule Therapeutics

  • Large Molecule Therapeutics
    Surface-Modified Nanoparticles Enhance Transurothelial Penetration and Delivery of Survivin siRNA in Treating Bladder Cancer
    Darryl T. Martin, Jill M. Steinbach, Jingchun Liu, Shogo Shimizu, Hristos Z. Kaimakliotis, Marcia A. Wheeler, Adam B. Hittelman, W. Mark Saltzman and Robert M. Weiss
    Mol Cancer Ther January 1 2014 13 (1) 71-81; DOI:10.1158/1535-7163.MCT-13-0502

  • Large Molecule Therapeutics
    Antitumor Effects of Immunotoxins Are Enhanced by Lowering HCK or Treatment with Src Kinase Inhibitors
    Xiu-Fen Liu, Laiman Xiang, David J. FitzGerald and Ira Pastan
    Mol Cancer Ther January 1 2014 13 (1) 82-89; DOI:10.1158/1535-7163.MCT-13-0726

  • Large Molecule Therapeutics
    Superior Antitumor Activity of a Novel Bispecific Antibody Cotargeting Human Epidermal Growth Factor Receptor 2 and Type I Insulin-like Growth Factor Receptor
    Chao Chen, Yanyu Zhang, Yu Zhang, Jingjing Li, Sai Wah Tsao and Mei-Yun Zhang
    Mol Cancer Ther January 1 2014 13 (1) 90-100; DOI:10.1158/1535-7163.MCT-13-0558

  • Large Molecule Therapeutics
    Tetravalent Antibody–scTRAIL Fusion Proteins with Improved Properties
    Oliver Seifert, Aline Plappert, Sina Fellermeier, Martin Siegemund, Klaus Pfizenmaier and Roland E. Kontermann
    Mol Cancer Ther January 1 2014 13 (1) 101-111; DOI:10.1158/1535-7163.MCT-13-0396

  • Large Molecule Therapeutics
    Combining Antibody-Directed Presentation of IL-15 and 4-1BBL in a Trifunctional Fusion Protein for Cancer Immunotherapy
    Vanessa Kermer, Nora Hornig, Markus Harder, Anastasiia Bondarieva, Roland E. Kontermann and Dafne Müller
    Mol Cancer Ther January 1 2014 13 (1) 112-121; DOI:10.1158/1535-7163.MCT-13-0282

Cancer Biology and Signal Transduction

  • Cancer Biology and Signal Transduction
    Response to MLN8237 in Pancreatic Cancer Is Not Dependent on RalA Phosphorylation
    Nicole F. Neel, Jeran K. Stratford, Vaishali Shinde, Jeffrey A. Ecsedy, Timothy D. Martin, Channing J. Der and Jen Jen Yeh
    Mol Cancer Ther January 1 2014 13 (1) 122-133; DOI:10.1158/1535-7163.MCT-12-1232

  • Cancer Biology and Signal Transduction
    Off-Target Effects of c-MET Inhibitors on Thyroid Cancer Cells
    Yan Zhou, Conghui Zhao, Sigal Gery, Glenn D. Braunstein, Ryoko Okamoto, Rocio Alvarez, Steven A. Miles, Ngan B. Doan, Jonathan W. Said, Jiang Gu and H. Phillip Koeffler
    Mol Cancer Ther January 1 2014 13 (1) 134-143; DOI:10.1158/1535-7163.MCT-13-0187

  • Cancer Biology and Signal Transduction
    Breaking the Invulnerability of Cancer Stem Cells: Two-Step Strategy to Kill the Stem-like Cell Subpopulation of Multiple Myeloma
    Agnieszka Morgenroth, Andreas T.J. Vogg, Boris D. Zlatopolskiy, Monika Siluschek, Caroline Oedekoven and Felix M. Mottaghy
    Mol Cancer Ther January 1 2014 13 (1) 144-153; DOI:10.1158/1535-7163.MCT-13-0240

  • Cancer Biology and Signal Transduction
    Targeting Sphingosine Kinase Induces Apoptosis and Tumor Regression for KSHV-Associated Primary Effusion Lymphoma
    Zhiqiang Qin, Lu Dai, Jimena Trillo-Tinoco, Can Senkal, Wenxue Wang, Tom Reske, Karlie Bonstaff, Luis Del Valle, Paulo Rodriguez, Erik Flemington, Christina Voelkel-Johnson, Charles D. Smith, Besim Ogretmen and Chris Parsons
    Mol Cancer Ther January 1 2014 13 (1) 154-164; DOI:10.1158/1535-7163.MCT-13-0466

  • Cancer Biology and Signal Transduction | AuthorChoice
    Hypoxia-Regulated Overexpression of Soluble VEGFR2 Controls Angiogenesis and Inhibits Tumor Growth
    Guillaume Collet, Nathalie Lamerant-Fayel, Magdalena Tertil, Bouchra El Hafny-Rahbi, Jacek Stepniewski, Alan Guichard, Alexandra Foucault-Collet, Krzysztof Klimkiewicz, Stéphane Petoud, Agata Matejuk, Catherine Grillon, Alicja Jozkowicz, Jozef Dulak and Claudine Kieda
    Mol Cancer Ther January 1 2014 13 (1) 165-178; DOI:10.1158/1535-7163.MCT-13-0637

  • Cancer Biology and Signal Transduction
    Reversible Action of Diaminothiazoles in Cancer Cells Is Implicated by the Induction of a Fast Conformational Change of Tubulin and Suppression of Microtubule Dynamics
    Nisha E. Thomas, Reshma Thamkachy, Krishnankutty C. Sivakumar, Krishnakumar J. Sreedevi, Xavier Lieben Louis, Sannu A. Thomas, Rohith Kumar, Kallikat N. Rajasekharan, Lynne Cassimeris and Suparna Sengupta
    Mol Cancer Ther January 1 2014 13 (1) 179-189; DOI:10.1158/1535-7163.MCT-13-0479

  • Cancer Biology and Signal Transduction | AuthorChoice
    Phosphoproteomic Profiling Identifies Focal Adhesion Kinase as a Mediator of Docetaxel Resistance in Castrate-Resistant Prostate Cancer
    Brian Y. Lee, Falko Hochgräfe, Hui-Ming Lin, Lesley Castillo, Jianmin Wu, Mark J. Raftery, S. Martin Shreeve, Lisa G. Horvath and Roger J. Daly
    Mol Cancer Ther January 1 2014 13 (1) 190-201; DOI:10.1158/1535-7163.MCT-13-0225-T

  • Cancer Biology and Signal Transduction
    Differential Therapeutic Effects of Anti–VEGF-A Antibody in Different Tumor Models: Implications for Choosing Appropriate Tumor Models for Drug Testing
    Dror Alishekevitz, Rotem Bril, David Loven, Valeria Miller, Tali Voloshin, Svetlana Gingis-Velistki, Ella Fremder, Stefan J. Scherer and Yuval Shaked
    Mol Cancer Ther January 1 2014 13 (1) 202-213; DOI:10.1158/1535-7163.MCT-13-0356

  • Cancer Biology and Signal Transduction
    Differential and Common DNA Repair Pathways for Topoisomerase I- and II-Targeted Drugs in a Genetic DT40 Repair Cell Screen Panel
    Yuko Maede, Hiroyasu Shimizu, Toru Fukushima, Toshiaki Kogame, Terukazu Nakamura, Tsuneharu Miki, Shunichi Takeda, Yves Pommier and Junko Murai
    Mol Cancer Ther January 1 2014 13 (1) 214-220; DOI:10.1158/1535-7163.MCT-13-0551

  • Cancer Biology and Signal Transduction
    Sorafenib Suppresses JNK-Dependent Apoptosis through Inhibition of ZAK
    Harina Vin, Grace Ching, Sandra S. Ojeda, Charles H. Adelmann, Vida Chitsazzadeh, David W. Dwyer, Haiching Ma, Karin Ehrenreiter, Manuela Baccarini, Rosamaria Ruggieri, Jonathan L. Curry, Ana M. Ciurea, Madeleine Duvic, Naifa L. Busaidy, Nizar M. Tannir and Kenneth Y. Tsai
    Mol Cancer Ther January 1 2014 13 (1) 221-229; DOI:10.1158/1535-7163.MCT-13-0561

  • Cancer Biology and Signal Transduction
    Protein-Tyrosine Phosphatase H1 Increases Breast Cancer Sensitivity to Antiestrogens by Dephosphorylating Estrogen Receptor at Tyr537
    Padmanaban S. Suresh, Shao Ma, Antimo Migliaccio and Guan Chen
    Mol Cancer Ther January 1 2014 13 (1) 230-238; DOI:10.1158/1535-7163.MCT-13-0610

  • Cancer Biology and Signal Transduction
    The Natural Inhibitor of DNA Topoisomerase I, Camptothecin, Modulates HIF-1α Activity by Changing miR Expression Patterns in Human Cancer Cells
    Davide Bertozzi, Jessica Marinello, Stefano G. Manzo, Francesca Fornari, Laura Gramantieri and Giovanni Capranico
    Mol Cancer Ther January 1 2014 13 (1) 239-248; DOI:10.1158/1535-7163.MCT-13-0729

Companion Diagnostics and Cancer Biomarkers

  • Companion Diagnostics and Cancer Biomarkers | AuthorChoice
    MRP1 Overexpression Determines Poor Prognosis in Prospectively Treated Patients with Localized High-Risk Soft Tissue Sarcoma of Limbs and Trunk Wall: An ISG/GEIS Study
    Javier Martin-Broto, Antonio M. Gutierrez, Rafael F. Ramos, José A. Lopez-Guerrero, Stefano Ferrari, Silvia Stacchiotti, Piero Picci, Silvia Calabuig, Paola Collini, Marco Gambarotti, Silvia Bague, Angelo P. Dei Tos, Elena Palassini, Pablo Luna, Josefina Cruz, Ricardo Cubedo, Javier Martinez-Trufero, Andres Poveda, Paolo G. Casali, Antonio Fernandez-Serra, Antonio Lopez-Pousa and Alessandro Gronchi
    Mol Cancer Ther January 1 2014 13 (1) 249-259; DOI:10.1158/1535-7163.MCT-13-0406

  • Companion Diagnostics and Cancer Biomarkers
    Proteomics of Cancer Cell Lines Resistant to Microtubule-Stabilizing Agents
    Jakob Albrethsen, Ruth H. Angeletti, Susan Band Horwitz and Chia-Ping Huang Yang
    Mol Cancer Ther January 1 2014 13 (1) 260-269; DOI:10.1158/1535-7163.MCT-13-0471

Corrections

  • Corrections
    Correction: Chemotherapy Counteracts Metastatic Dissemination Induced by Antiangiogenic Treatment in Mice
    Mol Cancer Ther January 1 2014 13 (1) 270-270; DOI:10.1158/1535-7163.MCT-13-0914

  • Corrections
    Correction: MicroRNA Regulation of Oncolytic Adenovirus 6 for Selective Treatment of Castration-Resistant Prostate Cancer
    Mol Cancer Ther January 1 2014 13 (1) 271-271; DOI:10.1158/1535-7163.MCT-13-0936

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Molecular Cancer Therapeutics: 13 (1)
January 2014
Volume 13, Issue 1
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Issue Highlights

  • Tetravalent Antibody–scTRAIL Fusion Proteins with Improved Properties
  • Synergistic Combination of Novel Tubulin Inhibitor ABI-274 and Vemurafenib Overcomes Vemurafenib Acquired Resistance in BRAFV600E Melanoma
  • Enhanced PI3K p110α Signaling Confers Acquired Lapatinib Resistance That Can Be Effectively Reversed by a p110α-Selective PI3K Inhibitor
  • Superior Antitumor Activity of a Novel Bispecific Antibody Cotargeting Human Epidermal Growth Factor Receptor 2 and Type I Insulin-like Growth Factor Receptor

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  • Large Molecule Therapeutics
  • Cancer Biology and Signal Transduction
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Molecular Cancer Therapeutics
eISSN: 1538-8514
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