Molecular Cancer Therapeutics: 13 (1)

Highlights

Highlights

Highlights of This Issue

Mol Cancer Ther January 1 2014 13 (1) 1-1;

Editorial

Editorial

A Message from the New Editor-in-Chief

Napoleone Ferrara

Mol Cancer Ther January 1 2014 13 (1) 3-4; DOI:10.1158/1535-7163.MCT-13-1077

Small Molecule Therapeutics

Small Molecule Therapeutics

Small-Molecule IAP Antagonists Sensitize Cancer Cells to TRAIL-Induced Apoptosis: Roles of XIAP and cIAPs

Darren Finlay, Mitchell Vamos, Marcos González-López, Robert J. Ardecky, Santhi Reddy Ganji, Hongbin Yuan, Ying Su, Trina R. Cooley, Curt T. Hauser, Kate Welsh, John C. Reed, Nicholas D.P. Cosford and Kristiina Vuori

Mol Cancer Ther January 1 2014 13 (1) 5-15; DOI:10.1158/1535-7163.MCT-13-0153
Small Molecule Therapeutics

Synergistic Combination of Novel Tubulin Inhibitor ABI-274 and Vemurafenib Overcomes Vemurafenib Acquired Resistance in BRAF^V600E Melanoma

Jin Wang, Jianjun Chen, Duane D. Miller and Wei Li

Mol Cancer Ther January 1 2014 13 (1) 16-26; DOI:10.1158/1535-7163.MCT-13-0212
Small Molecule Therapeutics

SC-60, a Dimer-Based Sorafenib Derivative, Shows a Better Anti–Hepatocellular Carcinoma Effect than Sorafenib in a Preclinical Hepatocellular Carcinoma Model

Wei-Tien Tai, Chung-Wai Shiau, Yong-Shi Li, Yao-Li Chen, Pei-Yi Chu, Jui-Wen Huang, Cheng-Yi Hsu, Yi-Chieh Hsu, Pei-Jer Chen and Kuen-Feng Chen

Mol Cancer Ther January 1 2014 13 (1) 27-36; DOI:10.1158/1535-7163.MCT-13-0595
Small Molecule Therapeutics

Synergistic Activities of MET/RON Inhibitor BMS-777607 and mTOR Inhibitor AZD8055 to Polyploid Cells Derived from Pancreatic Cancer and Cancer Stem Cells

Jun-Ying Zeng, Sharad Sharma, Yong-Qing Zhou, Hang-Ping Yao, Xing Hu, Ruiwen Zhang and Ming-Hai Wang

Mol Cancer Ther January 1 2014 13 (1) 37-48; DOI:10.1158/1535-7163.MCT-13-0242
Small Molecule Therapeutics

Lappaol F, a Novel Anticancer Agent Isolated from Plant Arctium Lappa L.

Qing Sun, Kanglun Liu, Xiaoling Shen, Weixin Jin, Lingyan Jiang, M. Saeed Sheikh, Yingjie Hu and Ying Huang

Mol Cancer Ther January 1 2014 13 (1) 49-59; DOI:10.1158/1535-7163.MCT-13-0552
Small Molecule Therapeutics

Enhanced PI3K p110α Signaling Confers Acquired Lapatinib Resistance That Can Be Effectively Reversed by a p110α-Selective PI3K Inhibitor

Samuel W. Brady, Jian Zhang, Daniel Seok, Hai Wang and Dihua Yu

Mol Cancer Ther January 1 2014 13 (1) 60-70; DOI:10.1158/1535-7163.MCT-13-0518

Large Molecule Therapeutics

Large Molecule Therapeutics

Surface-Modified Nanoparticles Enhance Transurothelial Penetration and Delivery of Survivin siRNA in Treating Bladder Cancer

Darryl T. Martin, Jill M. Steinbach, Jingchun Liu, Shogo Shimizu, Hristos Z. Kaimakliotis, Marcia A. Wheeler, Adam B. Hittelman, W. Mark Saltzman and Robert M. Weiss

Mol Cancer Ther January 1 2014 13 (1) 71-81; DOI:10.1158/1535-7163.MCT-13-0502
Large Molecule Therapeutics

Antitumor Effects of Immunotoxins Are Enhanced by Lowering HCK or Treatment with Src Kinase Inhibitors

Xiu-Fen Liu, Laiman Xiang, David J. FitzGerald and Ira Pastan

Mol Cancer Ther January 1 2014 13 (1) 82-89; DOI:10.1158/1535-7163.MCT-13-0726
Large Molecule Therapeutics

Superior Antitumor Activity of a Novel Bispecific Antibody Cotargeting Human Epidermal Growth Factor Receptor 2 and Type I Insulin-like Growth Factor Receptor

Chao Chen, Yanyu Zhang, Yu Zhang, Jingjing Li, Sai Wah Tsao and Mei-Yun Zhang

Mol Cancer Ther January 1 2014 13 (1) 90-100; DOI:10.1158/1535-7163.MCT-13-0558
Large Molecule Therapeutics

Tetravalent Antibody–scTRAIL Fusion Proteins with Improved Properties

Oliver Seifert, Aline Plappert, Sina Fellermeier, Martin Siegemund, Klaus Pfizenmaier and Roland E. Kontermann

Mol Cancer Ther January 1 2014 13 (1) 101-111; DOI:10.1158/1535-7163.MCT-13-0396
Large Molecule Therapeutics

Combining Antibody-Directed Presentation of IL-15 and 4-1BBL in a Trifunctional Fusion Protein for Cancer Immunotherapy

Vanessa Kermer, Nora Hornig, Markus Harder, Anastasiia Bondarieva, Roland E. Kontermann and Dafne Müller

Mol Cancer Ther January 1 2014 13 (1) 112-121; DOI:10.1158/1535-7163.MCT-13-0282

Cancer Biology and Signal Transduction

Cancer Biology and Signal Transduction

Response to MLN8237 in Pancreatic Cancer Is Not Dependent on RalA Phosphorylation

Nicole F. Neel, Jeran K. Stratford, Vaishali Shinde, Jeffrey A. Ecsedy, Timothy D. Martin, Channing J. Der and Jen Jen Yeh

Mol Cancer Ther January 1 2014 13 (1) 122-133; DOI:10.1158/1535-7163.MCT-12-1232
Cancer Biology and Signal Transduction

Off-Target Effects of c-MET Inhibitors on Thyroid Cancer Cells

Yan Zhou, Conghui Zhao, Sigal Gery, Glenn D. Braunstein, Ryoko Okamoto, Rocio Alvarez, Steven A. Miles, Ngan B. Doan, Jonathan W. Said, Jiang Gu and H. Phillip Koeffler

Mol Cancer Ther January 1 2014 13 (1) 134-143; DOI:10.1158/1535-7163.MCT-13-0187
Cancer Biology and Signal Transduction

Breaking the Invulnerability of Cancer Stem Cells: Two-Step Strategy to Kill the Stem-like Cell Subpopulation of Multiple Myeloma

Agnieszka Morgenroth, Andreas T.J. Vogg, Boris D. Zlatopolskiy, Monika Siluschek, Caroline Oedekoven and Felix M. Mottaghy

Mol Cancer Ther January 1 2014 13 (1) 144-153; DOI:10.1158/1535-7163.MCT-13-0240
Cancer Biology and Signal Transduction

Targeting Sphingosine Kinase Induces Apoptosis and Tumor Regression for KSHV-Associated Primary Effusion Lymphoma

Zhiqiang Qin, Lu Dai, Jimena Trillo-Tinoco, Can Senkal, Wenxue Wang, Tom Reske, Karlie Bonstaff, Luis Del Valle, Paulo Rodriguez, Erik Flemington, Christina Voelkel-Johnson, Charles D. Smith, Besim Ogretmen and Chris Parsons

Mol Cancer Ther January 1 2014 13 (1) 154-164; DOI:10.1158/1535-7163.MCT-13-0466
Cancer Biology and Signal Transduction | AuthorChoice

Hypoxia-Regulated Overexpression of Soluble VEGFR2 Controls Angiogenesis and Inhibits Tumor Growth

Guillaume Collet, Nathalie Lamerant-Fayel, Magdalena Tertil, Bouchra El Hafny-Rahbi, Jacek Stepniewski, Alan Guichard, Alexandra Foucault-Collet, Krzysztof Klimkiewicz, Stéphane Petoud, Agata Matejuk, Catherine Grillon, Alicja Jozkowicz, Jozef Dulak and Claudine Kieda

Mol Cancer Ther January 1 2014 13 (1) 165-178; DOI:10.1158/1535-7163.MCT-13-0637
Cancer Biology and Signal Transduction

Reversible Action of Diaminothiazoles in Cancer Cells Is Implicated by the Induction of a Fast Conformational Change of Tubulin and Suppression of Microtubule Dynamics

Nisha E. Thomas, Reshma Thamkachy, Krishnankutty C. Sivakumar, Krishnakumar J. Sreedevi, Xavier Lieben Louis, Sannu A. Thomas, Rohith Kumar, Kallikat N. Rajasekharan, Lynne Cassimeris and Suparna Sengupta

Mol Cancer Ther January 1 2014 13 (1) 179-189; DOI:10.1158/1535-7163.MCT-13-0479
Cancer Biology and Signal Transduction | AuthorChoice

Phosphoproteomic Profiling Identifies Focal Adhesion Kinase as a Mediator of Docetaxel Resistance in Castrate-Resistant Prostate Cancer

Brian Y. Lee, Falko Hochgräfe, Hui-Ming Lin, Lesley Castillo, Jianmin Wu, Mark J. Raftery, S. Martin Shreeve, Lisa G. Horvath and Roger J. Daly

Mol Cancer Ther January 1 2014 13 (1) 190-201; DOI:10.1158/1535-7163.MCT-13-0225-T
Cancer Biology and Signal Transduction

Differential Therapeutic Effects of Anti–VEGF-A Antibody in Different Tumor Models: Implications for Choosing Appropriate Tumor Models for Drug Testing

Dror Alishekevitz, Rotem Bril, David Loven, Valeria Miller, Tali Voloshin, Svetlana Gingis-Velistki, Ella Fremder, Stefan J. Scherer and Yuval Shaked

Mol Cancer Ther January 1 2014 13 (1) 202-213; DOI:10.1158/1535-7163.MCT-13-0356
Cancer Biology and Signal Transduction

Differential and Common DNA Repair Pathways for Topoisomerase I- and II-Targeted Drugs in a Genetic DT40 Repair Cell Screen Panel

Yuko Maede, Hiroyasu Shimizu, Toru Fukushima, Toshiaki Kogame, Terukazu Nakamura, Tsuneharu Miki, Shunichi Takeda, Yves Pommier and Junko Murai

Mol Cancer Ther January 1 2014 13 (1) 214-220; DOI:10.1158/1535-7163.MCT-13-0551
Cancer Biology and Signal Transduction

Sorafenib Suppresses JNK-Dependent Apoptosis through Inhibition of ZAK

Harina Vin, Grace Ching, Sandra S. Ojeda, Charles H. Adelmann, Vida Chitsazzadeh, David W. Dwyer, Haiching Ma, Karin Ehrenreiter, Manuela Baccarini, Rosamaria Ruggieri, Jonathan L. Curry, Ana M. Ciurea, Madeleine Duvic, Naifa L. Busaidy, Nizar M. Tannir and Kenneth Y. Tsai

Mol Cancer Ther January 1 2014 13 (1) 221-229; DOI:10.1158/1535-7163.MCT-13-0561
Cancer Biology and Signal Transduction

Protein-Tyrosine Phosphatase H1 Increases Breast Cancer Sensitivity to Antiestrogens by Dephosphorylating Estrogen Receptor at Tyr537

Padmanaban S. Suresh, Shao Ma, Antimo Migliaccio and Guan Chen

Mol Cancer Ther January 1 2014 13 (1) 230-238; DOI:10.1158/1535-7163.MCT-13-0610
Cancer Biology and Signal Transduction

The Natural Inhibitor of DNA Topoisomerase I, Camptothecin, Modulates HIF-1α Activity by Changing miR Expression Patterns in Human Cancer Cells

Davide Bertozzi, Jessica Marinello, Stefano G. Manzo, Francesca Fornari, Laura Gramantieri and Giovanni Capranico

Mol Cancer Ther January 1 2014 13 (1) 239-248; DOI:10.1158/1535-7163.MCT-13-0729

Companion Diagnostics and Cancer Biomarkers

Companion Diagnostics and Cancer Biomarkers | AuthorChoice

MRP1 Overexpression Determines Poor Prognosis in Prospectively Treated Patients with Localized High-Risk Soft Tissue Sarcoma of Limbs and Trunk Wall: An ISG/GEIS Study

Javier Martin-Broto, Antonio M. Gutierrez, Rafael F. Ramos, José A. Lopez-Guerrero, Stefano Ferrari, Silvia Stacchiotti, Piero Picci, Silvia Calabuig, Paola Collini, Marco Gambarotti, Silvia Bague, Angelo P. Dei Tos, Elena Palassini, Pablo Luna, Josefina Cruz, Ricardo Cubedo, Javier Martinez-Trufero, Andres Poveda, Paolo G. Casali, Antonio Fernandez-Serra, Antonio Lopez-Pousa and Alessandro Gronchi

Mol Cancer Ther January 1 2014 13 (1) 249-259; DOI:10.1158/1535-7163.MCT-13-0406
Companion Diagnostics and Cancer Biomarkers

Proteomics of Cancer Cell Lines Resistant to Microtubule-Stabilizing Agents

Jakob Albrethsen, Ruth H. Angeletti, Susan Band Horwitz and Chia-Ping Huang Yang

Mol Cancer Ther January 1 2014 13 (1) 260-269; DOI:10.1158/1535-7163.MCT-13-0471

Corrections

Corrections

Correction: Chemotherapy Counteracts Metastatic Dissemination Induced by Antiangiogenic Treatment in Mice

Mol Cancer Ther January 1 2014 13 (1) 270-270; DOI:10.1158/1535-7163.MCT-13-0914
Corrections

Correction: MicroRNA Regulation of Oncolytic Adenovirus 6 for Selective Treatment of Castration-Resistant Prostate Cancer

Mol Cancer Ther January 1 2014 13 (1) 271-271; DOI:10.1158/1535-7163.MCT-13-0936

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Highlights

Editorial

Small Molecule Therapeutics

Large Molecule Therapeutics

Cancer Biology and Signal Transduction

Companion Diagnostics and Cancer Biomarkers

Corrections

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