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Chemical Therapeutics

PG545, an Angiogenesis and Heparanase Inhibitor, Reduces Primary Tumor Growth and Metastasis in Experimental Pancreatic Cancer

Katherine T. Ostapoff, Niranjan Awasthi, Bercin Kutluk Cenik, Stefan Hinz, Keith Dredge, Roderich E. Schwarz and Rolf A. Brekken
Katherine T. Ostapoff
1Division of Surgical Oncology, Department of Surgery, 2Hamon Center for Therapeutic Oncology Research, 3Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas; 4University of Lübeck, Lübeck, Germany; and 5Progen Pharmaceuticals Ltd., Brisbane, Queensland, Australia
1Division of Surgical Oncology, Department of Surgery, 2Hamon Center for Therapeutic Oncology Research, 3Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas; 4University of Lübeck, Lübeck, Germany; and 5Progen Pharmaceuticals Ltd., Brisbane, Queensland, Australia
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Niranjan Awasthi
1Division of Surgical Oncology, Department of Surgery, 2Hamon Center for Therapeutic Oncology Research, 3Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas; 4University of Lübeck, Lübeck, Germany; and 5Progen Pharmaceuticals Ltd., Brisbane, Queensland, Australia
1Division of Surgical Oncology, Department of Surgery, 2Hamon Center for Therapeutic Oncology Research, 3Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas; 4University of Lübeck, Lübeck, Germany; and 5Progen Pharmaceuticals Ltd., Brisbane, Queensland, Australia
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Bercin Kutluk Cenik
1Division of Surgical Oncology, Department of Surgery, 2Hamon Center for Therapeutic Oncology Research, 3Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas; 4University of Lübeck, Lübeck, Germany; and 5Progen Pharmaceuticals Ltd., Brisbane, Queensland, Australia
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Stefan Hinz
1Division of Surgical Oncology, Department of Surgery, 2Hamon Center for Therapeutic Oncology Research, 3Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas; 4University of Lübeck, Lübeck, Germany; and 5Progen Pharmaceuticals Ltd., Brisbane, Queensland, Australia
1Division of Surgical Oncology, Department of Surgery, 2Hamon Center for Therapeutic Oncology Research, 3Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas; 4University of Lübeck, Lübeck, Germany; and 5Progen Pharmaceuticals Ltd., Brisbane, Queensland, Australia
1Division of Surgical Oncology, Department of Surgery, 2Hamon Center for Therapeutic Oncology Research, 3Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas; 4University of Lübeck, Lübeck, Germany; and 5Progen Pharmaceuticals Ltd., Brisbane, Queensland, Australia
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Keith Dredge
1Division of Surgical Oncology, Department of Surgery, 2Hamon Center for Therapeutic Oncology Research, 3Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas; 4University of Lübeck, Lübeck, Germany; and 5Progen Pharmaceuticals Ltd., Brisbane, Queensland, Australia
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Roderich E. Schwarz
1Division of Surgical Oncology, Department of Surgery, 2Hamon Center for Therapeutic Oncology Research, 3Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas; 4University of Lübeck, Lübeck, Germany; and 5Progen Pharmaceuticals Ltd., Brisbane, Queensland, Australia
1Division of Surgical Oncology, Department of Surgery, 2Hamon Center for Therapeutic Oncology Research, 3Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas; 4University of Lübeck, Lübeck, Germany; and 5Progen Pharmaceuticals Ltd., Brisbane, Queensland, Australia
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Rolf A. Brekken
1Division of Surgical Oncology, Department of Surgery, 2Hamon Center for Therapeutic Oncology Research, 3Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas; 4University of Lübeck, Lübeck, Germany; and 5Progen Pharmaceuticals Ltd., Brisbane, Queensland, Australia
1Division of Surgical Oncology, Department of Surgery, 2Hamon Center for Therapeutic Oncology Research, 3Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas; 4University of Lübeck, Lübeck, Germany; and 5Progen Pharmaceuticals Ltd., Brisbane, Queensland, Australia
1Division of Surgical Oncology, Department of Surgery, 2Hamon Center for Therapeutic Oncology Research, 3Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas; 4University of Lübeck, Lübeck, Germany; and 5Progen Pharmaceuticals Ltd., Brisbane, Queensland, Australia
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DOI: 10.1158/1535-7163.MCT-12-1123 Published July 2013
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Total399731072186

Cited By

Article Information

Volume 12, Issue 7, pp. 1190-1201

DOI 
https://doi.org/10.1158/1535-7163.MCT-12-1123
PubMed 
23696215

Published By 
American Association for Cancer Research
Print ISSN 
1535-7163
Online ISSN 
1538-8514
History 
  • Received December 4, 2012
  • Revision received May 10, 2013
  • Accepted May 10, 2013
  • Published first May 21, 2013.

Article Versions

  • Previous version (May 21, 2013 - 15:12).
  • Previous version (June 5, 2013 - 13:53).
  • Previous version (June 27, 2013 - 14:10).
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Copyright & Usage 
©2013 American Association for Cancer Research.

Author Information

  1. Katherine T. Ostapoff1,2,
  2. Niranjan Awasthi1,2,
  3. Bercin Kutluk Cenik2,
  4. Stefan Hinz1,2,4,
  5. Keith Dredge5,
  6. Roderich E. Schwarz1,2, and
  7. Rolf A. Brekken1,2,3
  1. Authors' Affiliations: 1Division of Surgical Oncology, Department of Surgery, 2Hamon Center for Therapeutic Oncology Research, 3Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas; 4University of Lübeck, Lübeck, Germany; and 5Progen Pharmaceuticals Ltd., Brisbane, Queensland, Australia
  1. Corresponding Author:
    Rolf A. Brekken, Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, TX 75390. Phone: 214-648-5151; Fax: 214-648-4940; E-mail: Rolf.Brekken{at}utsouthwestern.edu
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Molecular Cancer Therapeutics: 12 (7)
July 2013
Volume 12, Issue 7
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PG545, an Angiogenesis and Heparanase Inhibitor, Reduces Primary Tumor Growth and Metastasis in Experimental Pancreatic Cancer
Katherine T. Ostapoff, Niranjan Awasthi, Bercin Kutluk Cenik, Stefan Hinz, Keith Dredge, Roderich E. Schwarz and Rolf A. Brekken
Mol Cancer Ther July 1 2013 (12) (7) 1190-1201; DOI: 10.1158/1535-7163.MCT-12-1123

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PG545, an Angiogenesis and Heparanase Inhibitor, Reduces Primary Tumor Growth and Metastasis in Experimental Pancreatic Cancer
Katherine T. Ostapoff, Niranjan Awasthi, Bercin Kutluk Cenik, Stefan Hinz, Keith Dredge, Roderich E. Schwarz and Rolf A. Brekken
Mol Cancer Ther July 1 2013 (12) (7) 1190-1201; DOI: 10.1158/1535-7163.MCT-12-1123
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