Molecular Cancer Therapeutics: 12 (7)

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Highlights of This Issue

Mol Cancer Ther July 1 2013 12 (7) 1151-1151;

Review

Review

The Potential Role of miR-451 in Cancer Diagnosis, Prognosis, and Therapy

Xuan Pan, Rui Wang and Zhao-Xia Wang

Mol Cancer Ther July 1 2013 12 (7) 1153-1162; DOI:10.1158/1535-7163.MCT-12-0802

Chemical Therapeutics

Chemical Therapeutics

CXCR4-Targeted Therapy Inhibits VEGF Expression and Chondrosarcoma Angiogenesis and Metastasis

Xiaojuan Sun, Cherie Charbonneau, Lei Wei, Wentian Yang, Qian Chen and Richard M. Terek

Mol Cancer Ther July 1 2013 12 (7) 1163-1170; DOI:10.1158/1535-7163.MCT-12-1092
Chemical Therapeutics

CRM1 and BRAF Inhibition Synergize and Induce Tumor Regression in BRAF-Mutant Melanoma

Roberto A. Salas Fragomeni, Hye Won Chung, Yosef Landesman, William Senapedis, Jean-Richard Saint-Martin, Hensin Tsao, Keith T. Flaherty, Sharon Shacham, Michael Kauffman and James C. Cusack

Mol Cancer Ther July 1 2013 12 (7) 1171-1179; DOI:10.1158/1535-7163.MCT-12-1171
Chemical Therapeutics

Identification and Characterization of a Small-Molecule Inhibitor of Wnt Signaling in Glioblastoma Cells

Alessandra De Robertis, Silvia Valensin, Marco Rossi, Patrizia Tunici, Margherita Verani, Antonella De Rosa, Cinzia Giordano, Maurizio Varrone, Arianna Nencini, Carmela Pratelli, Tiziana Benicchi, Annette Bakker, Jeffrey Hill, Kanda Sangthongpitag, Vishal Pendharkar, Boping Liu, Fui Mee Ng, Siew Wen Then, Shi Jing Tai, Seong-Moon Cheong, Xi He, Andrea Caricasole and Massimiliano Salerno

Mol Cancer Ther July 1 2013 12 (7) 1180-1189; DOI:10.1158/1535-7163.MCT-12-1176-T
Chemical Therapeutics

PG545, an Angiogenesis and Heparanase Inhibitor, Reduces Primary Tumor Growth and Metastasis in Experimental Pancreatic Cancer

Katherine T. Ostapoff, Niranjan Awasthi, Bercin Kutluk Cenik, Stefan Hinz, Keith Dredge, Roderich E. Schwarz and Rolf A. Brekken

Mol Cancer Ther July 1 2013 12 (7) 1190-1201; DOI:10.1158/1535-7163.MCT-12-1123
Chemical Therapeutics

MPT0B098, a Novel Microtubule Inhibitor That Destabilizes the Hypoxia-Inducible Factor-1α mRNA through Decreasing Nuclear–Cytoplasmic Translocation of RNA-Binding Protein HuR

Yun-Ching Cheng, Jing-Ping Liou, Ching-Chuan Kuo, Wen-Yang Lai, Kuang-Hsing Shih, Chi-Yen Chang, Wen-Yu Pan, Joseph T. Tseng and Jang-Yang Chang

Mol Cancer Ther July 1 2013 12 (7) 1202-1212; DOI:10.1158/1535-7163.MCT-12-0778

Large Molecule Therapeutics

Large Molecule Therapeutics | AuthorChoice

IGF-1R Targeting Increases the Antitumor Effects of DNA-Damaging Agents in SCLC Model: An Opportunity to Increase the Efficacy of Standard Therapy

Charles Ferté, Yohann Loriot, Céline Clémenson, Frederic Commo, Andrea Gombos, Jean-Emmanuel Bibault, Ingrid Fumagalli, Saad Hamama, Nathalie Auger, Benoit Lahon, Cyrus Chargari, Julien Calderaro, Jean-Charles Soria and Eric Deutsch

Mol Cancer Ther July 1 2013 12 (7) 1213-1222; DOI:10.1158/1535-7163.MCT-12-1067
Large Molecule Therapeutics | AuthorChoice

Human Anti-Macrophage Migration Inhibitory Factor Antibodies Inhibit Growth of Human Prostate Cancer Cells In Vitro and In Vivo

Filza Hussain, Michael Freissmuth, Dirk Völkel, Michael Thiele, Patrice Douillard, Gerhard Antoine, Patrick Thurner, Hartmut Ehrlich, Hans-Peter Schwarz, Friedrich Scheiflinger and Randolf J. Kerschbaumer

Mol Cancer Ther July 1 2013 12 (7) 1223-1234; DOI:10.1158/1535-7163.MCT-12-0988
Large Molecule Therapeutics | Free Article

Multivalent Scaffold Proteins as Superagonists of TRAIL Receptor 2–Induced Apoptosis

Jeffery S. Swers, Luba Grinberg, Lin Wang, Hui Feng, Kristen Lekstrom, Rosa Carrasco, Zhan Xiao, Ivan Inigo, Ching Ching Leow, Herren Wu, David A. Tice and Manuel Baca

Mol Cancer Ther July 1 2013 12 (7) 1235-1244; DOI:10.1158/1535-7163.MCT-12-1107
Large Molecule Therapeutics

Fibroblast Growth Factor Receptor 3 Is a Rational Therapeutic Target in Bladder Cancer

Kilian M. Gust, David J. McConkey, Shannon Awrey, Paul K. Hegarty, Jing Qing, Jolanta Bondaruk, Avi Ashkenazi, Bogdan Czerniak, Colin P. Dinney and Peter C. Black

Mol Cancer Ther July 1 2013 12 (7) 1245-1254; DOI:10.1158/1535-7163.MCT-12-1150
Large Molecule Therapeutics

DCDT2980S, an Anti-CD22-Monomethyl Auristatin E Antibody–Drug Conjugate, Is a Potential Treatment for Non-Hodgkin Lymphoma

Dongwei Li, Kirsten Achilles Poon, Shang-Fan Yu, Randall Dere, MaryAnn Go, Jeffrey Lau, Bing Zheng, Kristi Elkins, Dimitry Danilenko, Katherine R. Kozak, Pamela Chan, Josefa Chuh, Xiaoyan Shi, Denise Nazzal, Franklin Fuh, Jacqueline McBride, Vanitha Ramakrishnan, Ruth de Tute, Andy Rawstron, Andrew S. Jack, Rong Deng, Yu-Waye Chu, David Dornan, Marna Williams, William Ho, Allen Ebens, Saileta Prabhu and Andrew G. Polson

Mol Cancer Ther July 1 2013 12 (7) 1255-1265; DOI:10.1158/1535-7163.MCT-12-1173

Cancer Therapeutics Insights

Cancer Therapeutics Insights

Triptolide Induces the Expression of miR-142-3p: A Negative Regulator of Heat Shock Protein 70 and Pancreatic Cancer Cell Proliferation

Tiffany N. MacKenzie, Nameeta Mujumdar, Sulagna Banerjee, Veena Sangwan, Aaron Sarver, Selwyn Vickers, Subbaya Subramanian and Ashok K. Saluja

Mol Cancer Ther July 1 2013 12 (7) 1266-1275; DOI:10.1158/1535-7163.MCT-12-1231
Cancer Therapeutics Insights

Resveratrol Induces Differentiation Markers Expression in Anaplastic Thyroid Carcinoma via Activation of Notch1 Signaling and Suppresses Cell Growth

Xiao-Min Yu, Renata Jaskula-Sztul, Kamal Ahmed, April D. Harrison, Muthusamy Kunnimalaiyaan and Herbert Chen

Mol Cancer Ther July 1 2013 12 (7) 1276-1287; DOI:10.1158/1535-7163.MCT-12-0841
Cancer Therapeutics Insights

REST Negatively and ISGF3 Positively Regulate the Human STAT1 Gene in Melanoma

James Amalraj, Samuel J. Cutler, Ibtisam Ghazawi, Glen M. Boyle and Stephen J. Ralph

Mol Cancer Ther July 1 2013 12 (7) 1288-1298; DOI:10.1158/1535-7163.MCT-12-0923
Cancer Therapeutics Insights

Drug Repurposing for Gastrointestinal Stromal Tumor

Ziyan Y. Pessetto, Scott J. Weir, Geetika Sethi, Melinda A. Broward and Andrew K. Godwin

Mol Cancer Ther July 1 2013 12 (7) 1299-1309; DOI:10.1158/1535-7163.MCT-12-0968
Cancer Therapeutics Insights

Metabolomics Identifies Pyrimidine Starvation as the Mechanism of 5-Aminoimidazole-4-Carboxamide-1-β-Riboside-Induced Apoptosis in Multiple Myeloma Cells

Carolyne Bardeleben, Sanjai Sharma, Joseph R. Reeve, Sara Bassilian, Patrick Frost, Bao Hoang, Yijiang Shi and Alan Lichtenstein

Mol Cancer Ther July 1 2013 12 (7) 1310-1321; DOI:10.1158/1535-7163.MCT-12-1042
Cancer Therapeutics Insights | AuthorChoice

Regorafenib Inhibits Growth, Angiogenesis, and Metastasis in a Highly Aggressive, Orthotopic Colon Cancer Model

Lotfi Abou-Elkacem, Susanne Arns, Gunnar Brix, Felix Gremse, Dieter Zopf, Fabian Kiessling and Wiltrud Lederle

Mol Cancer Ther July 1 2013 12 (7) 1322-1331; DOI:10.1158/1535-7163.MCT-12-1162
Cancer Therapeutics Insights

Antiproliferative Effects of Continued Mitogen-Activated Protein Kinase Pathway Inhibition following Acquired Resistance to BRAF and/or MEK Inhibition in Melanoma

Matteo S. Carlino, Kavitha Gowrishankar, Catherine A.B. Saunders, Gulietta M. Pupo, Stephanie Snoyman, Xu Dong Zhang, Robyn Saw, Therese M. Becker, Richard F. Kefford, Georgina V. Long and Helen Rizos

Mol Cancer Ther July 1 2013 12 (7) 1332-1342; DOI:10.1158/1535-7163.MCT-13-0011
Cancer Therapeutics Insights

Overlapping Functions of ABC Transporters in Topotecan Disposition as Determined in Gene Knockout Mouse Models

Amit K. Tiwari, Rong Zhang and James M. Gallo

Mol Cancer Ther July 1 2013 12 (7) 1343-1355; DOI:10.1158/1535-7163.MCT-13-0100
Cancer Therapeutics Insights

Zoledronic Acid Reverses the Epithelial–Mesenchymal Transition and Inhibits Self-Renewal of Breast Cancer Cells through Inactivation of NF-κB

Amanda J. Schech, Armina A. Kazi, Rabia A. Gilani and Angela H. Brodie

Mol Cancer Ther July 1 2013 12 (7) 1356-1366; DOI:10.1158/1535-7163.MCT-12-0304

Companion Diagnostics and Cancer Biomarkers

Companion Diagnostics and Cancer Biomarkers

Potential Role of mTORC2 as a Therapeutic Target in Clear Cell Carcinoma of the Ovary

Takeshi Hisamatsu, Seiji Mabuchi, Yuri Matsumoto, Mahiru Kawano, Tomoyuki Sasano, Ryoko Takahashi, Kenjiro Sawada, Kimihiko Ito, Hirohisa Kurachi, Russell J. Schilder, Joseph R. Testa and Tadashi Kimura

Mol Cancer Ther July 1 2013 12 (7) 1367-1377; DOI:10.1158/1535-7163.MCT-12-1185

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Review

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Large Molecule Therapeutics

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