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Molecular Cancer Therapeutics
Molecular Cancer Therapeutics
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Table of Contents

Highlights

  • Highlights
    Highlights of This Issue
    Mol Cancer Ther July 1 2013 12 (7) 1151-1151;

Review

  • Review
    The Potential Role of miR-451 in Cancer Diagnosis, Prognosis, and Therapy
    Xuan Pan, Rui Wang and Zhao-Xia Wang
    Mol Cancer Ther July 1 2013 12 (7) 1153-1162; DOI:10.1158/1535-7163.MCT-12-0802

Chemical Therapeutics

  • Chemical Therapeutics
    CXCR4-Targeted Therapy Inhibits VEGF Expression and Chondrosarcoma Angiogenesis and Metastasis
    Xiaojuan Sun, Cherie Charbonneau, Lei Wei, Wentian Yang, Qian Chen and Richard M. Terek
    Mol Cancer Ther July 1 2013 12 (7) 1163-1170; DOI:10.1158/1535-7163.MCT-12-1092

  • Chemical Therapeutics
    CRM1 and BRAF Inhibition Synergize and Induce Tumor Regression in BRAF-Mutant Melanoma
    Roberto A. Salas Fragomeni, Hye Won Chung, Yosef Landesman, William Senapedis, Jean-Richard Saint-Martin, Hensin Tsao, Keith T. Flaherty, Sharon Shacham, Michael Kauffman and James C. Cusack
    Mol Cancer Ther July 1 2013 12 (7) 1171-1179; DOI:10.1158/1535-7163.MCT-12-1171

  • Chemical Therapeutics
    Identification and Characterization of a Small-Molecule Inhibitor of Wnt Signaling in Glioblastoma Cells
    Alessandra De Robertis, Silvia Valensin, Marco Rossi, Patrizia Tunici, Margherita Verani, Antonella De Rosa, Cinzia Giordano, Maurizio Varrone, Arianna Nencini, Carmela Pratelli, Tiziana Benicchi, Annette Bakker, Jeffrey Hill, Kanda Sangthongpitag, Vishal Pendharkar, Boping Liu, Fui Mee Ng, Siew Wen Then, Shi Jing Tai, Seong-Moon Cheong, Xi He, Andrea Caricasole and Massimiliano Salerno
    Mol Cancer Ther July 1 2013 12 (7) 1180-1189; DOI:10.1158/1535-7163.MCT-12-1176-T

  • Chemical Therapeutics
    PG545, an Angiogenesis and Heparanase Inhibitor, Reduces Primary Tumor Growth and Metastasis in Experimental Pancreatic Cancer
    Katherine T. Ostapoff, Niranjan Awasthi, Bercin Kutluk Cenik, Stefan Hinz, Keith Dredge, Roderich E. Schwarz and Rolf A. Brekken
    Mol Cancer Ther July 1 2013 12 (7) 1190-1201; DOI:10.1158/1535-7163.MCT-12-1123

  • Chemical Therapeutics
    MPT0B098, a Novel Microtubule Inhibitor That Destabilizes the Hypoxia-Inducible Factor-1α mRNA through Decreasing Nuclear–Cytoplasmic Translocation of RNA-Binding Protein HuR
    Yun-Ching Cheng, Jing-Ping Liou, Ching-Chuan Kuo, Wen-Yang Lai, Kuang-Hsing Shih, Chi-Yen Chang, Wen-Yu Pan, Joseph T. Tseng and Jang-Yang Chang
    Mol Cancer Ther July 1 2013 12 (7) 1202-1212; DOI:10.1158/1535-7163.MCT-12-0778

Large Molecule Therapeutics

  • Large Molecule Therapeutics | AuthorChoice
    IGF-1R Targeting Increases the Antitumor Effects of DNA-Damaging Agents in SCLC Model: An Opportunity to Increase the Efficacy of Standard Therapy
    Charles Ferté, Yohann Loriot, Céline Clémenson, Frederic Commo, Andrea Gombos, Jean-Emmanuel Bibault, Ingrid Fumagalli, Saad Hamama, Nathalie Auger, Benoit Lahon, Cyrus Chargari, Julien Calderaro, Jean-Charles Soria and Eric Deutsch
    Mol Cancer Ther July 1 2013 12 (7) 1213-1222; DOI:10.1158/1535-7163.MCT-12-1067

  • Large Molecule Therapeutics | AuthorChoice
    Human Anti-Macrophage Migration Inhibitory Factor Antibodies Inhibit Growth of Human Prostate Cancer Cells In Vitro and In Vivo
    Filza Hussain, Michael Freissmuth, Dirk Völkel, Michael Thiele, Patrice Douillard, Gerhard Antoine, Patrick Thurner, Hartmut Ehrlich, Hans-Peter Schwarz, Friedrich Scheiflinger and Randolf J. Kerschbaumer
    Mol Cancer Ther July 1 2013 12 (7) 1223-1234; DOI:10.1158/1535-7163.MCT-12-0988

  • Large Molecule Therapeutics | Free Article
    Multivalent Scaffold Proteins as Superagonists of TRAIL Receptor 2–Induced Apoptosis
    Jeffery S. Swers, Luba Grinberg, Lin Wang, Hui Feng, Kristen Lekstrom, Rosa Carrasco, Zhan Xiao, Ivan Inigo, Ching Ching Leow, Herren Wu, David A. Tice and Manuel Baca
    Mol Cancer Ther July 1 2013 12 (7) 1235-1244; DOI:10.1158/1535-7163.MCT-12-1107

  • Large Molecule Therapeutics
    Fibroblast Growth Factor Receptor 3 Is a Rational Therapeutic Target in Bladder Cancer
    Kilian M. Gust, David J. McConkey, Shannon Awrey, Paul K. Hegarty, Jing Qing, Jolanta Bondaruk, Avi Ashkenazi, Bogdan Czerniak, Colin P. Dinney and Peter C. Black
    Mol Cancer Ther July 1 2013 12 (7) 1245-1254; DOI:10.1158/1535-7163.MCT-12-1150

  • Large Molecule Therapeutics
    DCDT2980S, an Anti-CD22-Monomethyl Auristatin E Antibody–Drug Conjugate, Is a Potential Treatment for Non-Hodgkin Lymphoma
    Dongwei Li, Kirsten Achilles Poon, Shang-Fan Yu, Randall Dere, MaryAnn Go, Jeffrey Lau, Bing Zheng, Kristi Elkins, Dimitry Danilenko, Katherine R. Kozak, Pamela Chan, Josefa Chuh, Xiaoyan Shi, Denise Nazzal, Franklin Fuh, Jacqueline McBride, Vanitha Ramakrishnan, Ruth de Tute, Andy Rawstron, Andrew S. Jack, Rong Deng, Yu-Waye Chu, David Dornan, Marna Williams, William Ho, Allen Ebens, Saileta Prabhu and Andrew G. Polson
    Mol Cancer Ther July 1 2013 12 (7) 1255-1265; DOI:10.1158/1535-7163.MCT-12-1173

Cancer Therapeutics Insights

  • Cancer Therapeutics Insights
    Triptolide Induces the Expression of miR-142-3p: A Negative Regulator of Heat Shock Protein 70 and Pancreatic Cancer Cell Proliferation
    Tiffany N. MacKenzie, Nameeta Mujumdar, Sulagna Banerjee, Veena Sangwan, Aaron Sarver, Selwyn Vickers, Subbaya Subramanian and Ashok K. Saluja
    Mol Cancer Ther July 1 2013 12 (7) 1266-1275; DOI:10.1158/1535-7163.MCT-12-1231

  • Cancer Therapeutics Insights
    Resveratrol Induces Differentiation Markers Expression in Anaplastic Thyroid Carcinoma via Activation of Notch1 Signaling and Suppresses Cell Growth
    Xiao-Min Yu, Renata Jaskula-Sztul, Kamal Ahmed, April D. Harrison, Muthusamy Kunnimalaiyaan and Herbert Chen
    Mol Cancer Ther July 1 2013 12 (7) 1276-1287; DOI:10.1158/1535-7163.MCT-12-0841

  • Cancer Therapeutics Insights
    REST Negatively and ISGF3 Positively Regulate the Human STAT1 Gene in Melanoma
    James Amalraj, Samuel J. Cutler, Ibtisam Ghazawi, Glen M. Boyle and Stephen J. Ralph
    Mol Cancer Ther July 1 2013 12 (7) 1288-1298; DOI:10.1158/1535-7163.MCT-12-0923

  • Cancer Therapeutics Insights
    Drug Repurposing for Gastrointestinal Stromal Tumor
    Ziyan Y. Pessetto, Scott J. Weir, Geetika Sethi, Melinda A. Broward and Andrew K. Godwin
    Mol Cancer Ther July 1 2013 12 (7) 1299-1309; DOI:10.1158/1535-7163.MCT-12-0968

  • Cancer Therapeutics Insights
    Metabolomics Identifies Pyrimidine Starvation as the Mechanism of 5-Aminoimidazole-4-Carboxamide-1-β-Riboside-Induced Apoptosis in Multiple Myeloma Cells
    Carolyne Bardeleben, Sanjai Sharma, Joseph R. Reeve, Sara Bassilian, Patrick Frost, Bao Hoang, Yijiang Shi and Alan Lichtenstein
    Mol Cancer Ther July 1 2013 12 (7) 1310-1321; DOI:10.1158/1535-7163.MCT-12-1042

  • Cancer Therapeutics Insights | AuthorChoice
    Regorafenib Inhibits Growth, Angiogenesis, and Metastasis in a Highly Aggressive, Orthotopic Colon Cancer Model
    Lotfi Abou-Elkacem, Susanne Arns, Gunnar Brix, Felix Gremse, Dieter Zopf, Fabian Kiessling and Wiltrud Lederle
    Mol Cancer Ther July 1 2013 12 (7) 1322-1331; DOI:10.1158/1535-7163.MCT-12-1162

  • Cancer Therapeutics Insights
    Antiproliferative Effects of Continued Mitogen-Activated Protein Kinase Pathway Inhibition following Acquired Resistance to BRAF and/or MEK Inhibition in Melanoma
    Matteo S. Carlino, Kavitha Gowrishankar, Catherine A.B. Saunders, Gulietta M. Pupo, Stephanie Snoyman, Xu Dong Zhang, Robyn Saw, Therese M. Becker, Richard F. Kefford, Georgina V. Long and Helen Rizos
    Mol Cancer Ther July 1 2013 12 (7) 1332-1342; DOI:10.1158/1535-7163.MCT-13-0011

  • Cancer Therapeutics Insights
    Overlapping Functions of ABC Transporters in Topotecan Disposition as Determined in Gene Knockout Mouse Models
    Amit K. Tiwari, Rong Zhang and James M. Gallo
    Mol Cancer Ther July 1 2013 12 (7) 1343-1355; DOI:10.1158/1535-7163.MCT-13-0100

  • Cancer Therapeutics Insights
    Zoledronic Acid Reverses the Epithelial–Mesenchymal Transition and Inhibits Self-Renewal of Breast Cancer Cells through Inactivation of NF-κB
    Amanda J. Schech, Armina A. Kazi, Rabia A. Gilani and Angela H. Brodie
    Mol Cancer Ther July 1 2013 12 (7) 1356-1366; DOI:10.1158/1535-7163.MCT-12-0304

Companion Diagnostics and Cancer Biomarkers

  • Companion Diagnostics and Cancer Biomarkers
    Potential Role of mTORC2 as a Therapeutic Target in Clear Cell Carcinoma of the Ovary
    Takeshi Hisamatsu, Seiji Mabuchi, Yuri Matsumoto, Mahiru Kawano, Tomoyuki Sasano, Ryoko Takahashi, Kenjiro Sawada, Kimihiko Ito, Hirohisa Kurachi, Russell J. Schilder, Joseph R. Testa and Tadashi Kimura
    Mol Cancer Ther July 1 2013 12 (7) 1367-1377; DOI:10.1158/1535-7163.MCT-12-1185

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Molecular Cancer Therapeutics: 12 (7)
July 2013
Volume 12, Issue 7
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Issue Highlights

  • PG545, an Angiogenesis and Heparanase Inhibitor, Reduces Primary Tumor Growth and Metastasis in Experimental Pancreatic Cancer
  • Multivalent Scaffold Proteins as Superagonists of TRAIL Receptor 2–Induced Apoptosis
  • CRM1 and BRAF Inhibition Synergize and Induce Tumor Regression in BRAF-Mutant Melanoma
  • DCDT2980S, an Anti-CD22-Monomethyl Auristatin E Antibody–Drug Conjugate, Is a Potential Treatment for Non-Hodgkin Lymphoma
  • Potential Role of mTORC2 as a Therapeutic Target in Clear Cell Carcinoma of the Ovary

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Molecular Cancer Therapeutics
eISSN: 1538-8514
ISSN: 1535-7163

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