Abstract C271: FAK inhibitor defactinib (VS-6063) enhances the efficacy of paclitaxel and preferentially targets ovarian cancer stem cells.

Christian M. Vidal; Vihren N. Kolev; Quentin G. Wright; Winnie F. Tam; David T. Weaver; Mahesh V. Padval; Qunli Xu; Jonathan A. Pachter

doi:10.1158/1535-7163.TARG-13-C271

Therapeutic Agents: Small Molecule Kinase Inhibitors

Abstract C271: FAK inhibitor defactinib (VS-6063) enhances the efficacy of paclitaxel and preferentially targets ovarian cancer stem cells.

Christian M. Vidal, Vihren N. Kolev, Quentin G. Wright, Winnie F. Tam, David T. Weaver, Mahesh V. Padval, Qunli Xu and Jonathan A. Pachter

Christian M. Vidal

Verastem, Cambridge, MA

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Vihren N. Kolev

Verastem, Cambridge, MA

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Quentin G. Wright

Verastem, Cambridge, MA

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Winnie F. Tam

Verastem, Cambridge, MA

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David T. Weaver

Verastem, Cambridge, MA

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Mahesh V. Padval

Verastem, Cambridge, MA

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Qunli Xu

Verastem, Cambridge, MA

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Jonathan A. Pachter

Verastem, Cambridge, MA

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DOI: 10.1158/1535-7163.TARG-13-C271 Published November 2013

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Volume 12, Issue 11 Supplement, pp. C271

DOI

https://doi.org/10.1158/1535-7163.TARG-13-C271

Published By

American Association for Cancer Research

Print ISSN

1535-7163

Online ISSN

1538-8514

Author Information

Christian M. Vidal,
Vihren N. Kolev,
Quentin G. Wright,
Winnie F. Tam,
David T. Weaver,
Mahesh V. Padval,
Qunli Xu, and
Jonathan A. Pachter

Verastem, Cambridge, MA

Molecular Cancer Therapeutics: 12 (11 Supplement)

November 2013
Volume 12, Issue 11 Supplement

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Abstract C271: FAK inhibitor defactinib (VS-6063) enhances the efficacy of paclitaxel and preferentially targets ovarian cancer stem cells.

Christian M. Vidal, Vihren N. Kolev, Quentin G. Wright, Winnie F. Tam, David T. Weaver, Mahesh V. Padval, Qunli Xu and Jonathan A. Pachter

Mol Cancer Ther November 1 2013 (12) (11 Supplement) C271; DOI: 10.1158/1535-7163.TARG-13-C271

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Abstract C271: FAK inhibitor defactinib (VS-6063) enhances the efficacy of paclitaxel and preferentially targets ovarian cancer stem cells.

Christian M. Vidal, Vihren N. Kolev, Quentin G. Wright, Winnie F. Tam, David T. Weaver, Mahesh V. Padval, Qunli Xu and Jonathan A. Pachter

Mol Cancer Ther November 1 2013 (12) (11 Supplement) C271; DOI: 10.1158/1535-7163.TARG-13-C271

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Therapeutic Agents: Small Molecule Kinase Inhibitors

Abstract PR13: Clinical safety and activity from a phase 1 study of LOXO-101, a selective TRKA/B/C inhibitor, in solid-tumor patients with NTRK gene fusions
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Abstract PR13: Clinical safety and activity from a phase 1 study of LOXO-101, a selective TRKA/B/C inhibitor, in solid-tumor patients with NTRK gene fusions
Abstract LB-A21: Single-agent activity and favorable pharmaceutical properties of orally bioavailable next-generation CDK4/6 inhibitor, ON 123300
Abstract LB-A20: Novel Dual Oncogenic Target Inhibitor against Allosteric Mitogen-Activated Protein Kinase (MEK1) and Phosphatidylinositol 3-Kinase (PI3K)

Show more Therapeutic Agents: Small Molecule Kinase Inhibitors: Poster Presentations - Proffered Abstracts

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Abstract C271: FAK inhibitor defactinib (VS-6063) enhances the efficacy of paclitaxel and preferentially targets ovarian cancer stem cells.

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