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Molecular Cancer Therapeutics
Molecular Cancer Therapeutics
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Table of Contents

Highlights

  • Highlights
    Highlights of This Issue
    Mol Cancer Ther October 1 2013 12 (10) 1923-1923;

Review

  • Review
    RAC1: An Emerging Therapeutic Option for Targeting Cancer Angiogenesis and Metastasis
    Hemant K. Bid, Ryan D. Roberts, Parmeet K. Manchanda and Peter J. Houghton
    Mol Cancer Ther October 1 2013 12 (10) 1925-1934; DOI:10.1158/1535-7163.MCT-13-0164

Small Molecule Therapeutics

  • Small Molecule Therapeutics
    Targeting Aberrant Sialylation in Cancer Cells Using a Fluorinated Sialic Acid Analog Impairs Adhesion, Migration, and In Vivo Tumor Growth
    Christian Büll, Thomas J. Boltje, Melissa Wassink, Annemarie M.A. de Graaf, Floris L. van Delft, Martijn H. den Brok and Gosse J. Adema
    Mol Cancer Ther October 1 2013 12 (10) 1935-1946; DOI:10.1158/1535-7163.MCT-13-0279

  • Small Molecule Therapeutics
    Novel Inhibitors of Cyclin-Dependent Kinases Combat Hepatocellular Carcinoma without Inducing Chemoresistance
    Christine Haider, Markus Grubinger, Eva Řezníčková, Thomas S. Weiss, Hans Rotheneder, Walter Miklos, Walter Berger, Radek Jorda, Marek Zatloukal, Tomáš Gucký, Miroslav Strnad, Vladimír Kryštof and Wolfgang Mikulits
    Mol Cancer Ther October 1 2013 12 (10) 1947-1957; DOI:10.1158/1535-7163.MCT-13-0263

  • Small Molecule Therapeutics
    Overcoming Platinum Resistance in Preclinical Models of Ovarian Cancer Using the Neddylation Inhibitor MLN4924
    Amir A. Jazaeri, Etsuko Shibata, Jonghoon Park, Jennifer L. Bryant, Mark R. Conaway, Susan C. Modesitt, Peter G. Smith, Michael A. Milhollen, Allison J. Berger and Anindya Dutta
    Mol Cancer Ther October 1 2013 12 (10) 1958-1967; DOI:10.1158/1535-7163.MCT-12-1028

  • Small Molecule Therapeutics
    Combination Drug Scheduling Defines a “Window of Opportunity” for Chemopotentiation of Gemcitabine by an Orally Bioavailable, Selective ChK1 Inhibitor, GNE-900
    Elizabeth Blackwood, Jennifer Epler, Ivana Yen, Michael Flagella, Tom O'Brien, Marie Evangelista, Stephen Schmidt, Yang Xiao, Jonathan Choi, Kaska Kowanetz, Judi Ramiscal, Kenton Wong, Diana Jakubiak, Sharon Yee, Gary Cain, Lewis Gazzard, Karen Williams, Jason Halladay, Peter K. Jackson and Shiva Malek
    Mol Cancer Ther October 1 2013 12 (10) 1968-1980; DOI:10.1158/1535-7163.MCT-12-1218

  • Small Molecule Therapeutics
    A Urokinase Receptor–Derived Peptide Inhibiting VEGF-Dependent Directional Migration and Vascular Sprouting
    Katia Bifulco, Immacolata Longanesi-Cattani, Eleonora Liguori, Claudio Arra, Domenica Rea, Maria Teresa Masucci, Mario De Rosa, Vincenzo Pavone, Maria Patrizia Stoppelli and Maria Vincenza Carriero
    Mol Cancer Ther October 1 2013 12 (10) 1981-1993; DOI:10.1158/1535-7163.MCT-13-0077

  • Small Molecule Therapeutics
    The Dual Pathway Inhibitor Rigosertib Is Effective in Direct Patient Tumor Xenografts of Head and Neck Squamous Cell Carcinomas
    Ryan T. Anderson, Stephen B. Keysar, Daniel W. Bowles, Magdalena J. Glogowska, David P. Astling, J. Jason Morton, Phuong Le, Adrian Umpierrez, Justin Eagles-Soukup, Gregory N. Gan, Brian W. Vogler, Daniel Sehrt, Sarah M. Takimoto, Dara L. Aisner, Francois Wilhelm, Barbara A. Frederick, Marileila Varella-Garcia, Aik-Choon Tan and Antonio Jimeno
    Mol Cancer Ther October 1 2013 12 (10) 1994-2005; DOI:10.1158/1535-7163.MCT-13-0206

  • Small Molecule Therapeutics
    Novel Treatment for Mantle Cell Lymphoma Including Therapy-Resistant Tumor by NF-κB and mTOR Dual-Targeting Approach
    Nagendra K. Chaturvedi, Rajkumar N. Rajule, Ashima Shukla, Prakash Radhakrishnan, Gordon L. Todd, Amarnath Natarajan, Julie M. Vose and Shantaram S. Joshi
    Mol Cancer Ther October 1 2013 12 (10) 2006-2017; DOI:10.1158/1535-7163.MCT-13-0239

  • Small Molecule Therapeutics
    Sunitinib and SU11652 Inhibit Acid Sphingomyelinase, Destabilize Lysosomes, and Inhibit Multidrug Resistance
    Anne-Marie Ellegaard, Line Groth-Pedersen, Viola Oorschot, Judith Klumperman, Thomas Kirkegaard, Jesper Nylandsted and Marja Jäättelä
    Mol Cancer Ther October 1 2013 12 (10) 2018-2030; DOI:10.1158/1535-7163.MCT-13-0084

Large Molecule Therapeutics

  • Large Molecule Therapeutics | AuthorChoice
    Preclinical Activity of the Type II CD20 Antibody GA101 (Obinutuzumab) Compared with Rituximab and Ofatumumab In Vitro and in Xenograft Models
    Sylvia Herter, Frank Herting, Olaf Mundigl, Inja Waldhauer, Tina Weinzierl, Tanja Fauti, Gunter Muth, Doris Ziegler-Landesberger, Erwin Van Puijenbroek, Sabine Lang, Minh Ngoc Duong, Lina Reslan, Christian A. Gerdes, Thomas Friess, Ute Baer, Helmut Burtscher, Michael Weidner, Charles Dumontet, Pablo Umana, Gerhard Niederfellner, Marina Bacac and Christian Klein
    Mol Cancer Ther October 1 2013 12 (10) 2031-2042; DOI:10.1158/1535-7163.MCT-12-1182

  • Large Molecule Therapeutics | AuthorChoice
    Targeting Aberrant DNA Double-Strand Break Repair in Triple-Negative Breast Cancer with Alpha-Particle Emitter Radiolabeled Anti-EGFR Antibody
    Hong Song, Mohammad Hedayati, Robert F. Hobbs, Chunbo Shao, Frank Bruchertseifer, Alfred Morgenstern, Theodore L. DeWeese and George Sgouros
    Mol Cancer Ther October 1 2013 12 (10) 2043-2054; DOI:10.1158/1535-7163.MCT-13-0108

  • Large Molecule Therapeutics
    The Functionalized Human Serine Protease Granzyme B/VEGF121 Targets Tumor Vasculature and Ablates Tumor Growth
    Khalid A. Mohamedali, Yu Cao, Lawrence H. Cheung, Walter N. Hittelman and Michael G. Rosenblum
    Mol Cancer Ther October 1 2013 12 (10) 2055-2066; DOI:10.1158/1535-7163.MCT-13-0165

Cancer Therapeutics Insights

  • Cancer Therapeutics Insights
    Berbamine Inhibits the Growth of Liver Cancer Cells and Cancer-Initiating Cells by Targeting Ca2+/Calmodulin-Dependent Protein Kinase II
    Zhipeng Meng, Tao Li, Xiaoxiao Ma, Xiaoqiong Wang, Carl Van Ness, Yichao Gan, Hong Zhou, Jinfen Tang, Guiyu Lou, Yafan Wang, Jun Wu, Yun Yen, Rongzhen Xu and Wendong Huang
    Mol Cancer Ther October 1 2013 12 (10) 2067-2077; DOI:10.1158/1535-7163.MCT-13-0314

  • Cancer Therapeutics Insights
    Histone Deacetylase Regulation of ATM-Mediated DNA Damage Signaling
    K. Ted Thurn, Scott Thomas, Paromita Raha, Ian Qureshi and Pamela N. Munster
    Mol Cancer Ther October 1 2013 12 (10) 2078-2087; DOI:10.1158/1535-7163.MCT-12-1242

  • Cancer Therapeutics Insights
    Histone Deacetylase Inhibition Overcomes Drug Resistance through a miRNA-Dependent Mechanism
    Tracy Murray-Stewart, Christin L. Hanigan, Patrick M. Woster, Laurence J. Marton and Robert A. Casero Jr
    Mol Cancer Ther October 1 2013 12 (10) 2088-2099; DOI:10.1158/1535-7163.MCT-13-0418

  • Cancer Therapeutics Insights
    PI3K Stimulates DNA Synthesis and Cell-Cycle Progression via Its p55PIK Regulatory Subunit Interaction with PCNA
    Guihua Wang, Xiaonian Cao, Senyan Lai, Xuelai Luo, Yongdong Feng, Xianmin Xia, Paul M. Yen, Jianping Gong and Junbo Hu
    Mol Cancer Ther October 1 2013 12 (10) 2100-2109; DOI:10.1158/1535-7163.MCT-12-0920

  • Cancer Therapeutics Insights
    Catalase Abrogates β-Lapachone–Induced PARP1 Hyperactivation–Directed Programmed Necrosis in NQO1-Positive Breast Cancers
    Erik A. Bey, Kathryn E. Reinicke, Melissa C. Srougi, Marie Varnes, Vernon E. Anderson, John J. Pink, Long Shan Li, Malina Patel, Lifen Cao, Zachary Moore, Amy Rommel, Michael Boatman, Cheryl Lewis, David M. Euhus, William G. Bornmann, Donald J. Buchsbaum, Douglas R. Spitz, Jinming Gao and David A. Boothman
    Mol Cancer Ther October 1 2013 12 (10) 2110-2120; DOI:10.1158/1535-7163.MCT-12-0962

  • Cancer Therapeutics Insights
    Sorafenib Overcomes Irinotecan Resistance in Colorectal Cancer by Inhibiting the ABCG2 Drug-Efflux Pump
    Thibault Mazard, Annick Causse, Joelle Simony, Wilhem Leconet, Nadia Vezzio-Vie, Adeline Torro, Marta Jarlier, Alexandre Evrard, Maguy Del Rio, Eric Assenat, Pierre Martineau, Marc Ychou, Bruno Robert and Celine Gongora
    Mol Cancer Ther October 1 2013 12 (10) 2121-2134; DOI:10.1158/1535-7163.MCT-12-0966

  • Cancer Therapeutics Insights
    Synthetic Lethal Targeting of PTEN-Deficient Cancer Cells Using Selective Disruption of Polynucleotide Kinase/Phosphatase
    Todd R. Mereniuk, Mohamed A.M. El Gendy, Ana M. Mendes-Pereira, Christopher J. Lord, Sunita Ghosh, Edan Foley, Alan Ashworth and Michael Weinfeld
    Mol Cancer Ther October 1 2013 12 (10) 2135-2144; DOI:10.1158/1535-7163.MCT-12-1093

  • Cancer Therapeutics Insights
    Glycolysis Inhibition Sensitizes Non–Small Cell Lung Cancer with T790M Mutation to Irreversible EGFR Inhibitors via Translational Suppression of Mcl-1 by AMPK Activation
    Sun Mi Kim, Mi Ran Yun, Yun Kyoung Hong, Flavio Solca, Joo-Hang Kim, Hyun-Jung Kim and Byoung Chul Cho
    Mol Cancer Ther October 1 2013 12 (10) 2145-2156; DOI:10.1158/1535-7163.MCT-12-1188

  • Cancer Therapeutics Insights
    Overexpression of Asparagine Synthetase and Matrix Metalloproteinase 19 Confers Cisplatin Sensitivity in Nasopharyngeal Carcinoma Cells
    Ran-Yi Liu, Zizheng Dong, Jianguo Liu, Ling Zhou, Wenlin Huang, Sok Kean Khoo, Zhongfa Zhang, David Petillo, Bin Tean Teh, Chao-Nan Qian and Jian-Ting Zhang
    Mol Cancer Ther October 1 2013 12 (10) 2157-2166; DOI:10.1158/1535-7163.MCT-12-1190

  • Cancer Therapeutics Insights
    Combining Erlotinib and Cetuximab Is Associated with Activity in Patients with Non–Small Cell Lung Cancer (Including Squamous Cell Carcinomas) and Wild-Type EGFR or Resistant Mutations
    Jennifer J. Wheler, Apostolia M. Tsimberidou, Gerald S. Falchook, Ralph G. Zinner, David S. Hong, Jansina Y. Fok, Siqing Fu, Sarina A. Piha-Paul, Aung Naing and Razelle Kurzrock
    Mol Cancer Ther October 1 2013 12 (10) 2167-2175; DOI:10.1158/1535-7163.MCT-12-1208

  • Cancer Therapeutics Insights
    EGFR Inhibition Promotes an Aggressive Invasion Pattern Mediated by Mesenchymal-like Tumor Cells within Squamous Cell Carcinomas
    Devraj Basu, Arnaud F. Bewley, Steven M. Sperry, Kathleen T. Montone, Phyllis A. Gimotty, Kati Rasanen, Nicole D. Facompre, Gregory S. Weinstein, Hiroshi Nakagawa, J. Alan Diehl, Anil K. Rustgi and Meenhard Herlyn
    Mol Cancer Ther October 1 2013 12 (10) 2176-2186; DOI:10.1158/1535-7163.MCT-12-1210

  • Cancer Therapeutics Insights
    Cetuximab Reverses the Warburg Effect by Inhibiting HIF-1–Regulated LDH-A
    Haiquan Lu, Xinqun Li, Zhongguang Luo, Jie Liu and Zhen Fan
    Mol Cancer Ther October 1 2013 12 (10) 2187-2199; DOI:10.1158/1535-7163.MCT-12-1245

  • Cancer Therapeutics Insights
    Niclosamide Overcomes Acquired Resistance to Erlotinib through Suppression of STAT3 in Non–Small Cell Lung Cancer
    Rui Li, Zhongliang Hu, Shi-Yong Sun, Zhuo G. Chen, Taofeek K. Owonikoko, Gabriel L. Sica, Suresh S. Ramalingam, Walter J. Curran, Fadlo R. Khuri and Xingming Deng
    Mol Cancer Ther October 1 2013 12 (10) 2200-2212; DOI:10.1158/1535-7163.MCT-13-0095

  • Cancer Therapeutics Insights
    Subtype-Specific MEK-PI3 Kinase Feedback as a Therapeutic Target in Pancreatic Adenocarcinoma
    Olga K. Mirzoeva, Eric A. Collisson, Peter M. Schaefer, Byron Hann, Yun K. Hom, Andrew H. Ko and W. Michael Korn
    Mol Cancer Ther October 1 2013 12 (10) 2213-2225; DOI:10.1158/1535-7163.MCT-13-0104

  • Cancer Therapeutics Insights
    Differential Induction of Apoptosis and Senescence by the DNA Methyltransferase Inhibitors 5-Azacytidine and 5-Aza-2′-Deoxycytidine in Solid Tumor Cells
    Sascha Venturelli, Alexander Berger, Timo Weiland, Frank Essmann, Michaela Waibel, Tina Nuebling, Sabine Häcker, Martin Schenk, Klaus Schulze-Osthoff, Helmut R. Salih, Simone Fulda, Bence Sipos, Ricky W. Johnstone, Ulrich M. Lauer and Michael Bitzer
    Mol Cancer Ther October 1 2013 12 (10) 2226-2236; DOI:10.1158/1535-7163.MCT-13-0137

  • Cancer Therapeutics Insights
    Chemotherapy Counteracts Metastatic Dissemination Induced by Antiangiogenic Treatment in Mice
    Alessandra Rovida, Vittoria Castiglioni, Alessandra Decio, Valentina Scarlato, Eugenio Scanziani, Raffaella Giavazzi and Marta Cesca
    Mol Cancer Ther October 1 2013 12 (10) 2237-2247; DOI:10.1158/1535-7163.MCT-13-0244

Companion Diagnostics and Biomarkers

  • Companion Diagnostics and Biomarkers | AuthorChoice
    Uracil–DNA Glycosylase Expression Determines Human Lung Cancer Cell Sensitivity to Pemetrexed
    Lachelle D. Weeks, Pingfu Fu and Stanton L. Gerson
    Mol Cancer Ther October 1 2013 12 (10) 2248-2260; DOI:10.1158/1535-7163.MCT-13-0172

  • Companion Diagnostics and Biomarkers | AuthorChoice
    Prognostic Role of Lemur Tyrosine Kinase-3 Germline Polymorphisms in Adjuvant Gastric Cancer in Japan and the United States
    Takeru Wakatsuki, Melissa J. LaBonte, Pierre O. Bohanes, Wu Zhang, Dongyun Yang, Mizutomo Azuma, Afsaneh Barzi, Yan Ning, Fotios Loupakis, Siamak Saadat, Nico Volz, Sebastian Stintzing, Rita El-Khoueiry, Wasaburo Koizumi, Masahiko Watanabe, Manish Shah, Justin Stebbing, Georgios Giamas and Heinz-Josef Lenz
    Mol Cancer Ther October 1 2013 12 (10) 2261-2272; DOI:10.1158/1535-7163.MCT-12-1134

Tools and Technologies

  • Tools and Technologies
    Receptor-Directed Chimeric Toxins Created by Sortase-Mediated Protein Fusion
    Andrew J. McCluskey and R. John Collier
    Mol Cancer Ther October 1 2013 12 (10) 2273-2281; DOI:10.1158/1535-7163.MCT-13-0358

Correction

  • Correction
    Correction: Inhibition of Monocarboxylate Transporter 2 Induces Senescence-Associated Mitochondrial Dysfunction and Suppresses Progression of Colorectal Malignancies In Vivo
    Mol Cancer Ther October 1 2013 12 (10) 2282-2282; DOI:10.1158/1535-7163.MCT-13-0727

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Molecular Cancer Therapeutics: 12 (10)
October 2013
Volume 12, Issue 10
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Issue Highlights

  • Differential Induction of Apoptosis and Senescence by the DNA Methyltransferase Inhibitors 5-Azacytidine and 5-Aza-2′-Deoxycytidine in Solid Tumor Cells
  • EGFR Inhibition Promotes an Aggressive Invasion Pattern Mediated by Mesenchymal-like Tumor Cells within Squamous Cell Carcinomas
  • The Functionalized Human Serine Protease Granzyme B/VEGF121 Targets Tumor Vasculature and Ablates Tumor Growth
  • Catalase Abrogates β-Lapachone–Induced PARP1 Hyperactivation–Directed Programmed Necrosis in NQO1-Positive Breast Cancers
  • Niclosamide Overcomes Acquired Resistance to Erlotinib through Suppression of STAT3 in Non–Small Cell Lung Cancer

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Molecular Cancer Therapeutics
eISSN: 1538-8514
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