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Molecular Cancer Therapeutics
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Preclinical Development

TPI-287, a New Taxane Family Member, Reduces the Brain Metastatic Colonization of Breast Cancer Cells

Daniel P. Fitzgerald, David L. Emerson, Yongzhen Qian, Talha Anwar, David J. Liewehr, Seth M. Steinberg, Sandra Silberman, Diane Palmieri and Patricia S. Steeg
Daniel P. Fitzgerald
Authors' Affiliations: 1Women's Cancers Section, Laboratory of Molecular Pharmacology, 2Biostatistics and Data Management Section, National Cancer Institute, Bethesda, Maryland; 3Bolder Biopath, Inc., Boulder, Colorado; 4Laboratory Animal Sciences Program, Science Applications International Corporation, National Cancer Institute, Frederick, Maryland; and 5Quintiles, Inc. Durham, North Carolina
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David L. Emerson
Authors' Affiliations: 1Women's Cancers Section, Laboratory of Molecular Pharmacology, 2Biostatistics and Data Management Section, National Cancer Institute, Bethesda, Maryland; 3Bolder Biopath, Inc., Boulder, Colorado; 4Laboratory Animal Sciences Program, Science Applications International Corporation, National Cancer Institute, Frederick, Maryland; and 5Quintiles, Inc. Durham, North Carolina
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Yongzhen Qian
Authors' Affiliations: 1Women's Cancers Section, Laboratory of Molecular Pharmacology, 2Biostatistics and Data Management Section, National Cancer Institute, Bethesda, Maryland; 3Bolder Biopath, Inc., Boulder, Colorado; 4Laboratory Animal Sciences Program, Science Applications International Corporation, National Cancer Institute, Frederick, Maryland; and 5Quintiles, Inc. Durham, North Carolina
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Talha Anwar
Authors' Affiliations: 1Women's Cancers Section, Laboratory of Molecular Pharmacology, 2Biostatistics and Data Management Section, National Cancer Institute, Bethesda, Maryland; 3Bolder Biopath, Inc., Boulder, Colorado; 4Laboratory Animal Sciences Program, Science Applications International Corporation, National Cancer Institute, Frederick, Maryland; and 5Quintiles, Inc. Durham, North Carolina
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David J. Liewehr
Authors' Affiliations: 1Women's Cancers Section, Laboratory of Molecular Pharmacology, 2Biostatistics and Data Management Section, National Cancer Institute, Bethesda, Maryland; 3Bolder Biopath, Inc., Boulder, Colorado; 4Laboratory Animal Sciences Program, Science Applications International Corporation, National Cancer Institute, Frederick, Maryland; and 5Quintiles, Inc. Durham, North Carolina
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Seth M. Steinberg
Authors' Affiliations: 1Women's Cancers Section, Laboratory of Molecular Pharmacology, 2Biostatistics and Data Management Section, National Cancer Institute, Bethesda, Maryland; 3Bolder Biopath, Inc., Boulder, Colorado; 4Laboratory Animal Sciences Program, Science Applications International Corporation, National Cancer Institute, Frederick, Maryland; and 5Quintiles, Inc. Durham, North Carolina
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Sandra Silberman
Authors' Affiliations: 1Women's Cancers Section, Laboratory of Molecular Pharmacology, 2Biostatistics and Data Management Section, National Cancer Institute, Bethesda, Maryland; 3Bolder Biopath, Inc., Boulder, Colorado; 4Laboratory Animal Sciences Program, Science Applications International Corporation, National Cancer Institute, Frederick, Maryland; and 5Quintiles, Inc. Durham, North Carolina
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Diane Palmieri
Authors' Affiliations: 1Women's Cancers Section, Laboratory of Molecular Pharmacology, 2Biostatistics and Data Management Section, National Cancer Institute, Bethesda, Maryland; 3Bolder Biopath, Inc., Boulder, Colorado; 4Laboratory Animal Sciences Program, Science Applications International Corporation, National Cancer Institute, Frederick, Maryland; and 5Quintiles, Inc. Durham, North Carolina
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Patricia S. Steeg
Authors' Affiliations: 1Women's Cancers Section, Laboratory of Molecular Pharmacology, 2Biostatistics and Data Management Section, National Cancer Institute, Bethesda, Maryland; 3Bolder Biopath, Inc., Boulder, Colorado; 4Laboratory Animal Sciences Program, Science Applications International Corporation, National Cancer Institute, Frederick, Maryland; and 5Quintiles, Inc. Durham, North Carolina
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DOI: 10.1158/1535-7163.MCT-12-0061 Published September 2012
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Cited By

Article Information

Volume 11, Issue 9, pp. 1959-1967

DOI 
https://doi.org/10.1158/1535-7163.MCT-12-0061
PubMed 
22622283

Published By 
American Association for Cancer Research
Print ISSN 
1535-7163
Online ISSN 
1538-8514
History 
  • Received January 25, 2012
  • Revision received March 28, 2012
  • Accepted April 13, 2012
  • Published first May 23, 2012.

Article Versions

  • Previous version (May 23, 2012 - 12:59).
  • Previous version (August 13, 2012 - 13:39).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2012 American Association for Cancer Research.

Author Information

  1. Daniel P. Fitzgerald1,
  2. David L. Emerson3,
  3. Yongzhen Qian4,
  4. Talha Anwar1,
  5. David J. Liewehr2,
  6. Seth M. Steinberg2,
  7. Sandra Silberman5,
  8. Diane Palmieri1, and
  9. Patricia S. Steeg1
  1. Authors' Affiliations: 1Women's Cancers Section, Laboratory of Molecular Pharmacology, 2Biostatistics and Data Management Section, National Cancer Institute, Bethesda, Maryland; 3Bolder Biopath, Inc., Boulder, Colorado; 4Laboratory Animal Sciences Program, Science Applications International Corporation, National Cancer Institute, Frederick, Maryland; and 5Quintiles, Inc. Durham, North Carolina
  1. Corresponding Author:
    Patricia S. Steeg, National Institutes of Health, Building 37, Room 1122, Bethesda, MD 20892. Phone: 301-402-2732; Fax: 301-402-8910; Email: steegp{at}mail.nih.gov
  • Current address for D.P. Fitzgerald: Otsuka Pharmaceuticals, Rockville, Maryland; and current address for T. Anwar: University of Michigan Medical School, Ann Arbor, Michigan.

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Molecular Cancer Therapeutics: 11 (9)
September 2012
Volume 11, Issue 9
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TPI-287, a New Taxane Family Member, Reduces the Brain Metastatic Colonization of Breast Cancer Cells
Daniel P. Fitzgerald, David L. Emerson, Yongzhen Qian, Talha Anwar, David J. Liewehr, Seth M. Steinberg, Sandra Silberman, Diane Palmieri and Patricia S. Steeg
Mol Cancer Ther September 1 2012 (11) (9) 1959-1967; DOI: 10.1158/1535-7163.MCT-12-0061

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TPI-287, a New Taxane Family Member, Reduces the Brain Metastatic Colonization of Breast Cancer Cells
Daniel P. Fitzgerald, David L. Emerson, Yongzhen Qian, Talha Anwar, David J. Liewehr, Seth M. Steinberg, Sandra Silberman, Diane Palmieri and Patricia S. Steeg
Mol Cancer Ther September 1 2012 (11) (9) 1959-1967; DOI: 10.1158/1535-7163.MCT-12-0061
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