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Molecular Cancer Therapeutics
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Preclinical Development

ERK Inhibition Overcomes Acquired Resistance to MEK Inhibitors

Georgia Hatzivassiliou, Bonnie Liu, Carol O'Brien, Jill M. Spoerke, Klaus P. Hoeflich, Peter M. Haverty, Robert Soriano, William F. Forrest, Sherry Heldens, Huifen Chen, Karen Toy, Connie Ha, Wei Zhou, Kyung Song, Lori S. Friedman, Lukas C. Amler, Garret M. Hampton, John Moffat, Marcia Belvin and Mark R. Lackner
Georgia Hatzivassiliou
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Bonnie Liu
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Connie Ha
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Kyung Song
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Lukas C. Amler
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DOI: 10.1158/1535-7163.MCT-11-1010 Published May 2012
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Cited By

Article Information

Volume 11, Issue 5, pp. 1143-1154

DOI 
https://doi.org/10.1158/1535-7163.MCT-11-1010
PubMed 
22402123

Published By 
American Association for Cancer Research
Print ISSN 
1535-7163
Online ISSN 
1538-8514
History 
  • Received December 13, 2011
  • Revision received February 21, 2012
  • Accepted February 23, 2012
  • Published first March 8, 2012.

Article Versions

  • Previous version (March 8, 2012 - 10:33).
  • Previous version (May 1, 2012 - 07:47).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2012 American Association for Cancer Research.

Author Information

  1. Georgia Hatzivassiliou,
  2. Bonnie Liu,
  3. Carol O'Brien,
  4. Jill M. Spoerke,
  5. Klaus P. Hoeflich,
  6. Peter M. Haverty,
  7. Robert Soriano,
  8. William F. Forrest,
  9. Sherry Heldens,
  10. Huifen Chen,
  11. Karen Toy,
  12. Connie Ha,
  13. Wei Zhou,
  14. Kyung Song,
  15. Lori S. Friedman,
  16. Lukas C. Amler,
  17. Garret M. Hampton,
  18. John Moffat,
  19. Marcia Belvin, and
  20. Mark R. Lackner
  1. Authors' Affiliation: Genentech, Inc., 1 DNA Way, South San Francisco, California
  1. Corresponding Authors:
    Georgia Hatzivassiliou, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080. E-mail: hatzivassiliou.georgia{at}gene.com; and Mark R. Lackner, Phone: 650-467-1846; Fax: 650-467-7571; E-mail: mlackner{at}gene.com
  1. B. Liu and C. O'Brien contributed equally to this work.

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Molecular Cancer Therapeutics: 11 (5)
May 2012
Volume 11, Issue 5
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ERK Inhibition Overcomes Acquired Resistance to MEK Inhibitors
Georgia Hatzivassiliou, Bonnie Liu, Carol O'Brien, Jill M. Spoerke, Klaus P. Hoeflich, Peter M. Haverty, Robert Soriano, William F. Forrest, Sherry Heldens, Huifen Chen, Karen Toy, Connie Ha, Wei Zhou, Kyung Song, Lori S. Friedman, Lukas C. Amler, Garret M. Hampton, John Moffat, Marcia Belvin and Mark R. Lackner
Mol Cancer Ther May 1 2012 (11) (5) 1143-1154; DOI: 10.1158/1535-7163.MCT-11-1010

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ERK Inhibition Overcomes Acquired Resistance to MEK Inhibitors
Georgia Hatzivassiliou, Bonnie Liu, Carol O'Brien, Jill M. Spoerke, Klaus P. Hoeflich, Peter M. Haverty, Robert Soriano, William F. Forrest, Sherry Heldens, Huifen Chen, Karen Toy, Connie Ha, Wei Zhou, Kyung Song, Lori S. Friedman, Lukas C. Amler, Garret M. Hampton, John Moffat, Marcia Belvin and Mark R. Lackner
Mol Cancer Ther May 1 2012 (11) (5) 1143-1154; DOI: 10.1158/1535-7163.MCT-11-1010
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