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Preclinical Development

Effects of Anti-VEGF on Pharmacokinetics, Biodistribution, and Tumor Penetration of Trastuzumab in a Preclinical Breast Cancer Model

Cinthia V. Pastuskovas, Eduardo E. Mundo, Simon P. Williams, Tapan K. Nayak, Jason Ho, Sheila Ulufatu, Suzanna Clark, Sarajane Ross, Eric Cheng, Kathryn Parsons-Reponte, Gary Cain, Marjie Van Hoy, Nicholas Majidy, Sheila Bheddah, Josefa dela Cruz Chuh, Katherine R. Kozak, Nicholas Lewin-Koh, Peter Nauka, Daniela Bumbaca, Mark Sliwkowski, Jay Tibbitts, Frank-Peter Theil, Paul J. Fielder, Leslie A. Khawli and C. Andrew Boswell
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DOI: 10.1158/1535-7163.MCT-11-0742-T Published March 2012
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Total645949693856

Cited By

Article Information

Volume 11, Issue 3, pp. 752-762

DOI 
https://doi.org/10.1158/1535-7163.MCT-11-0742-T
PubMed 
22222630

Published By 
American Association for Cancer Research
Print ISSN 
1535-7163
Online ISSN 
1538-8514
History 
  • Received September 19, 2011
  • Revision received December 1, 2011
  • Accepted December 21, 2011
  • Published first January 5, 2012.

Article Versions

  • Previous version (January 5, 2012 - 15:22).
  • Previous version (February 21, 2012 - 13:35).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2012 American Association for Cancer Research.

Author Information

  1. Cinthia V. Pastuskovas1,
  2. Eduardo E. Mundo1,
  3. Simon P. Williams1,
  4. Tapan K. Nayak2,
  5. Jason Ho1,
  6. Sheila Ulufatu1,
  7. Suzanna Clark1,
  8. Sarajane Ross1,
  9. Eric Cheng1,
  10. Kathryn Parsons-Reponte1,
  11. Gary Cain1,
  12. Marjie Van Hoy1,
  13. Nicholas Majidy1,
  14. Sheila Bheddah1,
  15. Josefa dela Cruz Chuh1,
  16. Katherine R. Kozak1,
  17. Nicholas Lewin-Koh1,
  18. Peter Nauka1,
  19. Daniela Bumbaca1,
  20. Mark Sliwkowski1,
  21. Jay Tibbitts1,
  22. Frank-Peter Theil1,
  23. Paul J. Fielder1,
  24. Leslie A. Khawli1, and
  25. C. Andrew Boswell1
  1. Authors' Affiliations: 1Genentech Research and Early Development, South San Francisco, California; and 2Pharma Research and Early Development, Hoffmann-La Roche Ltd., Basel, Switzerland
  1. Corresponding Authors:
    Leslie A. Khawli, Early Development Pharmacokinetics and Pharmacodynamics, Genentech, Inc., South San Francisco, CA 94080. Phone: 650-225-6509; Fax: 650-742-5234; E-mail: khawli.leslie{at}gene.com; and C. Andrew Boswell, Phone: 650-467-4603; Fax: 650-742-5234; E-mail: boswell.andy{at}gene.com
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Molecular Cancer Therapeutics: 11 (3)
March 2012
Volume 11, Issue 3
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Effects of Anti-VEGF on Pharmacokinetics, Biodistribution, and Tumor Penetration of Trastuzumab in a Preclinical Breast Cancer Model
Cinthia V. Pastuskovas, Eduardo E. Mundo, Simon P. Williams, Tapan K. Nayak, Jason Ho, Sheila Ulufatu, Suzanna Clark, Sarajane Ross, Eric Cheng, Kathryn Parsons-Reponte, Gary Cain, Marjie Van Hoy, Nicholas Majidy, Sheila Bheddah, Josefa dela Cruz Chuh, Katherine R. Kozak, Nicholas Lewin-Koh, Peter Nauka, Daniela Bumbaca, Mark Sliwkowski, Jay Tibbitts, Frank-Peter Theil, Paul J. Fielder, Leslie A. Khawli and C. Andrew Boswell
Mol Cancer Ther March 1 2012 (11) (3) 752-762; DOI: 10.1158/1535-7163.MCT-11-0742-T

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Effects of Anti-VEGF on Pharmacokinetics, Biodistribution, and Tumor Penetration of Trastuzumab in a Preclinical Breast Cancer Model
Cinthia V. Pastuskovas, Eduardo E. Mundo, Simon P. Williams, Tapan K. Nayak, Jason Ho, Sheila Ulufatu, Suzanna Clark, Sarajane Ross, Eric Cheng, Kathryn Parsons-Reponte, Gary Cain, Marjie Van Hoy, Nicholas Majidy, Sheila Bheddah, Josefa dela Cruz Chuh, Katherine R. Kozak, Nicholas Lewin-Koh, Peter Nauka, Daniela Bumbaca, Mark Sliwkowski, Jay Tibbitts, Frank-Peter Theil, Paul J. Fielder, Leslie A. Khawli and C. Andrew Boswell
Mol Cancer Ther March 1 2012 (11) (3) 752-762; DOI: 10.1158/1535-7163.MCT-11-0742-T
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