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Molecular Cancer Therapeutics
Molecular Cancer Therapeutics
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About the Cover

Cover image

Cover image expansion

Olfactomedin-like 3 (Olfml3), a proangiogenic cue and a BMP4 agonist, is produced by both tumor endothelial cells and accompanying pericytes and deposited in the perivascular compartment. Blocking Olfml3 regresses the tumor vasculature, decreases pericyte coverage, and inhibits the progression of tumors. Olfml3 blockade provides an alternative strategy to control tumor growth by targeting a single molecule that affects two distinct cell types within the tumor microenvironment. For details, see article by Miljkovic-Licina and colleagues on page 2588.

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Molecular Cancer Therapeutics: 11 (12)
December 2012
Volume 11, Issue 12
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Issue Highlights

  • Targeting Olfactomedin-like 3 Inhibits Tumor Growth by Impairing Angiogenesis and Pericyte Coverage
  • BMS-754807, a Small-Molecule Inhibitor of Insulin-like Growth Factor-1 Receptor/Insulin Receptor, Enhances Gemcitabine Response in Pancreatic Cancer
  • It's About Time: Lessons for Solid Tumors from Chronic Myelogenous Leukemia Therapy
  • Targeting KRAS-Mutant Non–Small Cell Lung Cancer with the Hsp90 Inhibitor Ganetespib
  • Development of Gene Expression–Based Score to Predict Sensitivity of Multiple Myeloma Cells to DNA Methylation Inhibitors
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Molecular Cancer Therapeutics
eISSN: 1538-8514
ISSN: 1535-7163

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