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Molecular Cancer Therapeutics
Molecular Cancer Therapeutics
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Table of Contents

Highlights

  • Highlights
    Highlights of This Issue
    Mol Cancer Ther September 1 2011 10 (9) 1531-1531;

Review

  • Review | Free Article
    The Role of Autophagy in Cancer: Therapeutic Implications
    Zhineng J. Yang, Cheng E. Chee, Shengbing Huang and Frank A. Sinicrope
    Mol Cancer Ther September 1 2011 10 (9) 1533-1541; DOI:10.1158/1535-7163.MCT-11-0047

Therapeutic Discovery

  • Therapeutic Discovery
    Potent, Selective Inhibitors of Fibroblast Growth Factor Receptor Define Fibroblast Growth Factor Dependence in Preclinical Cancer Models
    Matthew Squires, George Ward, Gordan Saxty, Valerio Berdini, Anne Cleasby, Peter King, Patrick Angibaud, Tim Perera, Lynsey Fazal, Douglas Ross, Charlotte Griffiths Jones, Andrew Madin, Rajdeep K. Benning, Emma Vickerstaffe, Alistair O'Brien, Martyn Frederickson, Michael Reader, Christopher Hamlett, Michael A. Batey, Sharna Rich, Maria Carr, Darcey Miller, Ruth Feltell, Abarna Thiru, Susanne Bethell, Lindsay A. Devine, Brent L. Graham, Andrew Pike, Jose Cosme, Edward J. Lewis, Eddy Freyne, John Lyons, Julie Irving, Christopher Murray, David R. Newell and Neil T. Thompson
    Mol Cancer Ther September 1 2011 10 (9) 1542-1552; DOI:10.1158/1535-7163.MCT-11-0426

  • Therapeutic Discovery
    Inhibition of Dynamin by Dynole 34-2 Induces Cell Death following Cytokinesis Failure in Cancer Cells
    Megan Chircop, Swetha Perera, Anna Mariana, Hui Lau, Maggie P.C. Ma, Jayne Gilbert, Nigel C. Jones, Christopher P. Gordon, Kelly A. Young, Andrew Morokoff, Jennette Sakoff, Terence J. O'Brien, Adam McCluskey and Phillip J. Robinson
    Mol Cancer Ther September 1 2011 10 (9) 1553-1562; DOI:10.1158/1535-7163.MCT-11-0067

  • Therapeutic Discovery
    Linear Chain PEGylated Recombinant Bacillus Thiaminolyticus Thiaminase I Enzyme Has Growth Inhibitory Activity against Lymphoid Leukemia Cell Lines
    Abigail Daily, Shuqian Liu, Younsoo Bae, Saloni Bhatnagar and Jeffrey A. Moscow
    Mol Cancer Ther September 1 2011 10 (9) 1563-1570; DOI:10.1158/1535-7163.MCT-11-0003

  • Therapeutic Discovery
    Antitumor Actions of Ruthenium(III)-Based Nitric Oxide Scavengers and Nitric Oxide Synthase Inhibitors
    Frederick W. Flitney, Rebecca J. Pritchard, Gordon D. Kennovin, Stuart K. Bisland, David G. Hirst and Simon P. Fricker
    Mol Cancer Ther September 1 2011 10 (9) 1571-1580; DOI:10.1158/1535-7163.MCT-10-0840

  • Therapeutic Discovery
    Compensatory Pathways Induced by MEK Inhibition Are Effective Drug Targets for Combination Therapy against Castration-Resistant Prostate Cancer
    Daniel Gioeli, Winfried Wunderlich, Judith Sebolt-Leopold, Stefan Bekiranov, Julia D. Wulfkuhle, Emanuel F. Petricoin III, Mark Conaway and Michael J. Weber
    Mol Cancer Ther September 1 2011 10 (9) 1581-1590; DOI:10.1158/1535-7163.MCT-10-1033

  • Therapeutic Discovery
    Histone Deacetylase Cytoplasmic Trapping by a Novel Fluorescent HDAC Inhibitor
    Yali Kong, Mira Jung, Kan Wang, Scott Grindrod, Alfredo Velena, Sung A. Lee, Sivanesan Dakshanamurthy, Yonghong Yang, Matthew Miessau, Chaoyi Zheng, Anatoly Dritschilo and Milton L. Brown
    Mol Cancer Ther September 1 2011 10 (9) 1591-1599; DOI:10.1158/1535-7163.MCT-10-0779

  • Therapeutic Discovery
    Long Pentraxin-3 Inhibits FGF8b-Dependent Angiogenesis and Growth of Steroid Hormone–Regulated Tumors
    Daria Leali, Patrizia Alessi, Daniela Coltrini, Roberto Ronca, Michela Corsini, Giorgia Nardo, Stefano Indraccolo and Marco Presta
    Mol Cancer Ther September 1 2011 10 (9) 1600-1610; DOI:10.1158/1535-7163.MCT-11-0286

  • Therapeutic Discovery
    Transformation-Dependent Silencing of Tumor-Selective Apoptosis-Inducing TRAIL by DNA Hypermethylation Is Antagonized by Decitabine
    Per Lund, Irina Kotova, Valérie Kedinger, Harshal Khanwalkar, Emilie Voltz, William C. Hahn and Hinrich Gronemeyer
    Mol Cancer Ther September 1 2011 10 (9) 1611-1623; DOI:10.1158/1535-7163.MCT-11-0140

  • Therapeutic Discovery
    Mechanisms of Action of a Dual Cdc7/Cdk9 Kinase Inhibitor against Quiescent and Proliferating CLL Cells
    Alessandro Natoni, Laura S. Murillo, Anna E. Kliszczak, Mark A. Catherwood, Alessia Montagnoli, Afshin Samali, Michael O'Dwyer and Corrado Santocanale
    Mol Cancer Ther September 1 2011 10 (9) 1624-1634; DOI:10.1158/1535-7163.MCT-10-1119

  • Therapeutic Discovery
    Synthetic Triterpenoid Cyano Enone of Methyl Boswellate Activates Intrinsic, Extrinsic, and Endoplasmic Reticulum Stress Cell Death Pathways in Tumor Cell Lines
    Palaniyandi Ravanan, Renata Sano, Priti Talwar, Satoshi Ogasawara, Shu-ichi Matsuzawa, Michael Cuddy, Sanjay K. Singh, G.S.R. Subba Rao, Paturu Kondaiah and John C. Reed
    Mol Cancer Ther September 1 2011 10 (9) 1635-1643; DOI:10.1158/1535-7163.MCT-10-0887

  • Therapeutic Discovery
    Inhibition of the Acetyltransferases p300 and CBP Reveals a Targetable Function for p300 in the Survival and Invasion Pathways of Prostate Cancer Cell Lines
    Frédéric R. Santer, Philipp P.S. Höschele, Su Jung Oh, Holger H.H. Erb, Jan Bouchal, Ilaria T. Cavarretta, Walther Parson, David J. Meyers, Philip A. Cole and Zoran Culig
    Mol Cancer Ther September 1 2011 10 (9) 1644-1655; DOI:10.1158/1535-7163.MCT-11-0182

  • Therapeutic Discovery
    Antitumor Activity of a Recombinant Soluble Ectodomain of Mutant Human Fibroblast Growth Factor Receptor-2 IIIc
    Ju Wang, Xue-ting Liu, Hui Huang, Gang Xiao, Zhi-you Zhou, Yang Chen, Zhi-hong Yu, Shui-lian He, An-an Chen, Ding-ding Wang, Ying He, Zhi-cheng Zhang and An Hong
    Mol Cancer Ther September 1 2011 10 (9) 1656-1666; DOI:10.1158/1535-7163.MCT-11-0163

  • Therapeutic Discovery
    Nerve Growth Factor Links Oral Cancer Progression, Pain, and Cachexia
    Yi Ye, Dongmin Dang, Jianan Zhang, Chi T. Viet, David K. Lam, John C. Dolan, Jennifer L. Gibbs and Brian L. Schmidt
    Mol Cancer Ther September 1 2011 10 (9) 1667-1676; DOI:10.1158/1535-7163.MCT-11-0123

  • Therapeutic Discovery
    Human Monoclonal Antibody Fragments Binding to Insulin-like Growth Factors I and II with Picomolar Affinity
    Qi Zhao, Yang Feng, Zhongyu Zhu and Dimiter S. Dimitrov
    Mol Cancer Ther September 1 2011 10 (9) 1677-1685; DOI:10.1158/1535-7163.MCT-11-0281

Preclinical Development

  • Preclinical Development
    Carfilzomib Interacts Synergistically with Histone Deacetylase Inhibitors in Mantle Cell Lymphoma Cells In Vitro and In Vivo
    Girija Dasmahapatra, Dmitry Lembersky, Minkyeong P. Son, Elisa Attkisson, Paul Dent, Richard I. Fisher, Jonathan W. Friedberg and Steven Grant
    Mol Cancer Ther September 1 2011 10 (9) 1686-1697; DOI:10.1158/1535-7163.MCT-10-1108

  • Preclinical Development
    Impact of APE1/Ref-1 Redox Inhibition on Pancreatic Tumor Growth
    Melissa L. Fishel, Yanlin Jiang, N.V. Rajeshkumar, Glenda Scandura, Anthony L. Sinn, Ying He, Changyu Shen, David R. Jones, Karen E. Pollok, Mircea Ivan, Anirban Maitra and Mark R. Kelley
    Mol Cancer Ther September 1 2011 10 (9) 1698-1708; DOI:10.1158/1535-7163.MCT-11-0107

  • Preclinical Development
    Spectrum of Cellular Responses to Pyriplatin, a Monofunctional Cationic Antineoplastic Platinum(II) Compound, in Human Cancer Cells
    Katherine S. Lovejoy, Maria Serova, Ivan Bieche, Shahin Emami, Maurizio D'Incalci, Massimo Broggini, Eugenio Erba, Christian Gespach, Esteban Cvitkovic, Sandrine Faivre, Eric Raymond and Stephen J. Lippard
    Mol Cancer Ther September 1 2011 10 (9) 1709-1719; DOI:10.1158/1535-7163.MCT-11-0250

  • Preclinical Development
    Liposomal Delivery of MicroRNA-7–Expressing Plasmid Overcomes Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor-Resistance in Lung Cancer Cells
    Kammei Rai, Nagio Takigawa, Sachio Ito, Hiromi Kashihara, Eiki Ichihara, Tatsuji Yasuda, Kenji Shimizu, Mitsune Tanimoto and Katsuyuki Kiura
    Mol Cancer Ther September 1 2011 10 (9) 1720-1727; DOI:10.1158/1535-7163.MCT-11-0220

  • Preclinical Development
    In Vitro and In Vivo Responses of Advanced Prostate Tumors to PSMA ADC, an Auristatin-Conjugated Antibody to Prostate-Specific Membrane Antigen
    Xinning Wang, Dangshe Ma, William C. Olson and Warren D.W. Heston
    Mol Cancer Ther September 1 2011 10 (9) 1728-1739; DOI:10.1158/1535-7163.MCT-11-0191

  • Preclinical Development
    Discovery of a Small Molecule Targeting IRA2 Deletion in Budding Yeast and Neurofibromin Loss in Malignant Peripheral Nerve Sheath Tumor Cells
    Matthew Wood, Melissa Rawe, Gunnar Johansson, Shu Pang, Ryan S. Soderquist, Ami V. Patel, Sandra Nelson, William Seibel, Nancy Ratner and Yolanda Sanchez
    Mol Cancer Ther September 1 2011 10 (9) 1740-1750; DOI:10.1158/1535-7163.MCT-11-0309

Molecular Medicine in Practice

  • Molecular Medicine in Practice
    Exon 11 Skipping of E-Cadherin RNA Downregulates Its Expression in Head and Neck Cancer Cells
    Sanjai Sharma, Wei Liao, Xiaofeng Zhou, David T.W. Wong and Alan Lichtenstein
    Mol Cancer Ther September 1 2011 10 (9) 1751-1759; DOI:10.1158/1535-7163.MCT-11-0248

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Molecular Cancer Therapeutics: 10 (9)
September 2011
Volume 10, Issue 9
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Issue Highlights

  • Exon 11 Skipping of E-Cadherin RNA Downregulates Its Expression in Head and Neck Cancer Cells

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Molecular Cancer Therapeutics
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