Table of Contents

Therapeutic Discovery

• Therapeutic Discovery

  Potent, Selective Inhibitors of Fibroblast Growth Factor Receptor Define Fibroblast Growth Factor Dependence in Preclinical Cancer Models

  Matthew Squires, George Ward, Gordan Saxty, Valerio Berdini, Anne Cleasby, Peter King, Patrick Angibaud, Tim Perera, Lynsey Fazal, Douglas Ross, Charlotte Griffiths Jones, Andrew Madin, Rajdeep K. Benning, Emma Vickerstaffe, Alistair O'Brien, Martyn Frederickson, Michael Reader, Christopher Hamlett, Michael A. Batey, Sharna Rich, Maria Carr, Darcey Miller, Ruth Feltell, Abarna Thiru, Susanne Bethell, Lindsay A. Devine, Brent L. Graham, Andrew Pike, Jose Cosme, Edward J. Lewis, Eddy Freyne, John Lyons, Julie Irving, Christopher Murray, David R. Newell and Neil T. Thompson

  Mol Cancer Ther September 1 2011 10 (9) 1542-1552; DOI:10.1158/1535-7163.MCT-11-0426

  
  
• Therapeutic Discovery

  Inhibition of Dynamin by Dynole 34-2 Induces Cell Death following Cytokinesis Failure in Cancer Cells

  Megan Chircop, Swetha Perera, Anna Mariana, Hui Lau, Maggie P.C. Ma, Jayne Gilbert, Nigel C. Jones, Christopher P. Gordon, Kelly A. Young, Andrew Morokoff, Jennette Sakoff, Terence J. O'Brien, Adam McCluskey and Phillip J. Robinson

  Mol Cancer Ther September 1 2011 10 (9) 1553-1562; DOI:10.1158/1535-7163.MCT-11-0067

  
  
• Therapeutic Discovery

  Linear Chain PEGylated Recombinant Bacillus Thiaminolyticus Thiaminase I Enzyme Has Growth Inhibitory Activity against Lymphoid Leukemia Cell Lines

  Abigail Daily, Shuqian Liu, Younsoo Bae, Saloni Bhatnagar and Jeffrey A. Moscow

  Mol Cancer Ther September 1 2011 10 (9) 1563-1570; DOI:10.1158/1535-7163.MCT-11-0003

  
  
• Therapeutic Discovery

  Antitumor Actions of Ruthenium(III)-Based Nitric Oxide Scavengers and Nitric Oxide Synthase Inhibitors

  Frederick W. Flitney, Rebecca J. Pritchard, Gordon D. Kennovin, Stuart K. Bisland, David G. Hirst and Simon P. Fricker

  Mol Cancer Ther September 1 2011 10 (9) 1571-1580; DOI:10.1158/1535-7163.MCT-10-0840

  
  
• Therapeutic Discovery

  Compensatory Pathways Induced by MEK Inhibition Are Effective Drug Targets for Combination Therapy against Castration-Resistant Prostate Cancer

  Daniel Gioeli, Winfried Wunderlich, Judith Sebolt-Leopold, Stefan Bekiranov, Julia D. Wulfkuhle, Emanuel F. Petricoin III, Mark Conaway and Michael J. Weber

  Mol Cancer Ther September 1 2011 10 (9) 1581-1590; DOI:10.1158/1535-7163.MCT-10-1033

  
  
• Therapeutic Discovery

  Histone Deacetylase Cytoplasmic Trapping by a Novel Fluorescent HDAC Inhibitor

  Yali Kong, Mira Jung, Kan Wang, Scott Grindrod, Alfredo Velena, Sung A. Lee, Sivanesan Dakshanamurthy, Yonghong Yang, Matthew Miessau, Chaoyi Zheng, Anatoly Dritschilo and Milton L. Brown

  Mol Cancer Ther September 1 2011 10 (9) 1591-1599; DOI:10.1158/1535-7163.MCT-10-0779

  
  
• Therapeutic Discovery

  Long Pentraxin-3 Inhibits FGF8b-Dependent Angiogenesis and Growth of Steroid Hormone–Regulated Tumors

  Daria Leali, Patrizia Alessi, Daniela Coltrini, Roberto Ronca, Michela Corsini, Giorgia Nardo, Stefano Indraccolo and Marco Presta

  Mol Cancer Ther September 1 2011 10 (9) 1600-1610; DOI:10.1158/1535-7163.MCT-11-0286

  
  
• Therapeutic Discovery

  Transformation-Dependent Silencing of Tumor-Selective Apoptosis-Inducing TRAIL by DNA Hypermethylation Is Antagonized by Decitabine

  Per Lund, Irina Kotova, Valérie Kedinger, Harshal Khanwalkar, Emilie Voltz, William C. Hahn and Hinrich Gronemeyer

  Mol Cancer Ther September 1 2011 10 (9) 1611-1623; DOI:10.1158/1535-7163.MCT-11-0140

  
  
• Therapeutic Discovery

  Mechanisms of Action of a Dual Cdc7/Cdk9 Kinase Inhibitor against Quiescent and Proliferating CLL Cells

  Alessandro Natoni, Laura S. Murillo, Anna E. Kliszczak, Mark A. Catherwood, Alessia Montagnoli, Afshin Samali, Michael O'Dwyer and Corrado Santocanale

  Mol Cancer Ther September 1 2011 10 (9) 1624-1634; DOI:10.1158/1535-7163.MCT-10-1119

  
  
• Therapeutic Discovery

  Synthetic Triterpenoid Cyano Enone of Methyl Boswellate Activates Intrinsic, Extrinsic, and Endoplasmic Reticulum Stress Cell Death Pathways in Tumor Cell Lines

  Palaniyandi Ravanan, Renata Sano, Priti Talwar, Satoshi Ogasawara, Shu-ichi Matsuzawa, Michael Cuddy, Sanjay K. Singh, G.S.R. Subba Rao, Paturu Kondaiah and John C. Reed

  Mol Cancer Ther September 1 2011 10 (9) 1635-1643; DOI:10.1158/1535-7163.MCT-10-0887

  
  
• Therapeutic Discovery

  Inhibition of the Acetyltransferases p300 and CBP Reveals a Targetable Function for p300 in the Survival and Invasion Pathways of Prostate Cancer Cell Lines

  Frédéric R. Santer, Philipp P.S. Höschele, Su Jung Oh, Holger H.H. Erb, Jan Bouchal, Ilaria T. Cavarretta, Walther Parson, David J. Meyers, Philip A. Cole and Zoran Culig

  Mol Cancer Ther September 1 2011 10 (9) 1644-1655; DOI:10.1158/1535-7163.MCT-11-0182

  
  
• Therapeutic Discovery

  Antitumor Activity of a Recombinant Soluble Ectodomain of Mutant Human Fibroblast Growth Factor Receptor-2 IIIc

  Ju Wang, Xue-ting Liu, Hui Huang, Gang Xiao, Zhi-you Zhou, Yang Chen, Zhi-hong Yu, Shui-lian He, An-an Chen, Ding-ding Wang, Ying He, Zhi-cheng Zhang and An Hong

  Mol Cancer Ther September 1 2011 10 (9) 1656-1666; DOI:10.1158/1535-7163.MCT-11-0163

  
  
• Therapeutic Discovery

  Nerve Growth Factor Links Oral Cancer Progression, Pain, and Cachexia

  Yi Ye, Dongmin Dang, Jianan Zhang, Chi T. Viet, David K. Lam, John C. Dolan, Jennifer L. Gibbs and Brian L. Schmidt

  Mol Cancer Ther September 1 2011 10 (9) 1667-1676; DOI:10.1158/1535-7163.MCT-11-0123

  
  
• Therapeutic Discovery

  Human Monoclonal Antibody Fragments Binding to Insulin-like Growth Factors I and II with Picomolar Affinity

  Qi Zhao, Yang Feng, Zhongyu Zhu and Dimiter S. Dimitrov

  Mol Cancer Ther September 1 2011 10 (9) 1677-1685; DOI:10.1158/1535-7163.MCT-11-0281