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Molecular Cancer Therapeutics
Molecular Cancer Therapeutics
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Table of Contents

Highlights

  • Highlights
    Highlights of This Issue
    Mol Cancer Ther August 1 2011 10 (8) 1309-1309;

Spotlight on Clinical Response

  • Spotlight on Clinical Response
    A Pilot Clinical Study of Treatment Guided by Personalized Tumorgrafts in Patients with Advanced Cancer
    Manuel Hidalgo, Elizabeth Bruckheimer, N.V. Rajeshkumar, Ignacio Garrido-Laguna, Elizabeth De Oliveira, Belen Rubio-Viqueira, Steven Strawn, Michael J. Wick, James Martell and David Sidransky
    Mol Cancer Ther August 1 2011 10 (8) 1311-1316; DOI:10.1158/1535-7163.MCT-11-0233

Therapeutic Discovery

  • Therapeutic Discovery
    Phenotypic Reversion of Invasive Neurofibromin-Deficient Schwannoma by FTS: Ras Inhibition Reduces BMP4/Erk/Smad Signaling
    Batya Barkan, Yoel Kloog and Marcelo Ehrlich
    Mol Cancer Ther August 1 2011 10 (8) 1317-1326; DOI:10.1158/1535-7163.MCT-10-1087

  • Therapeutic Discovery
    Dual Targeting of Tumor Angiogenesis and Chemotherapy by Endostatin–Cytosine Deaminase–Uracil Phosphoribosyltransferase
    Chun-Te Chen, Hirohito Yamaguchi, Hong-Jen Lee, Yi Du, Heng-Huan Lee, Weiya Xia, Wen-Hsuan Yu, Jennifer L. Hsu, Chia-Jui Yen, Hui-Lung Sun, Yan Wang, Edward T.H. Yeh, Gabriel N. Hortobagyi and Mien-Chie Hung
    Mol Cancer Ther August 1 2011 10 (8) 1327-1336; DOI:10.1158/1535-7163.MCT-10-1117

  • Therapeutic Discovery
    MicroRNA-199a-3p Is Downregulated in Human Osteosarcoma and Regulates Cell Proliferation and Migration
    Zhenfeng Duan, Edwin Choy, David Harmon, Xianzhe Liu, Michiro Susa, Henry Mankin and Francis Hornicek
    Mol Cancer Ther August 1 2011 10 (8) 1337-1345; DOI:10.1158/1535-7163.MCT-11-0096

  • Therapeutic Discovery
    Berberine Suppresses Androgen Receptor Signaling in Prostate Cancer
    Jing Li, Bo Cao, Xichun Liu, Xueqi Fu, Zhenggang Xiong, Li Chen, Oliver Sartor, Yan Dong and Haitao Zhang
    Mol Cancer Ther August 1 2011 10 (8) 1346-1356; DOI:10.1158/1535-7163.MCT-10-0985

  • Therapeutic Discovery
    High-Risk Endometrial Carcinoma Profiling Identifies TGF-β1 as a Key Factor in the Initiation of Tumor Invasion
    Laura Muinelo-Romay, Eva Colas, Jorge Barbazan, Lorena Alonso-Alconada, Marta Alonso-Nocelo, Marta Bouso, Teresa Curiel, Juan Cueva, Urbano Anido, Jeronimo Forteza, Antonio Gil-Moreno, Jaume Reventos, Rafael Lopez-Lopez and Miguel Abal
    Mol Cancer Ther August 1 2011 10 (8) 1357-1366; DOI:10.1158/1535-7163.MCT-10-1019

  • Therapeutic Discovery
    Truncated ErbB2 Expressed in Tumor Cell Nuclei Contributes to Acquired Therapeutic Resistance to ErbB2 Kinase Inhibitors
    Wenle Xia, Zuguo Liu, Rongrong Zong, Leihua Liu, Sumin Zhao, Sarah S. Bacus, Yubin Mao, Jia He, Julia D. Wulfkuhle, Emanuel F. Petricoin III, Takuya Osada, Xiao-Yi Yang, Zachary C. Hartman, Timothy M. Clay, Kimberly L. Blackwell, Herbert K. Lyerly and Neil L. Spector
    Mol Cancer Ther August 1 2011 10 (8) 1367-1374; DOI:10.1158/1535-7163.MCT-10-0991

  • Therapeutic Discovery
    Enhanced Antitumor Effects by Chemical Modified IGb3 Analogues
    Zhixia Zhou, Cai Zhang, Chengfeng Xia, Wenlan Chen, Huawei Zhu, Pingping Shang, Fang Ma, Peng George Wang, Jian Zhang, Wenfang Xu and Zhigang Tian
    Mol Cancer Ther August 1 2011 10 (8) 1375-1384; DOI:10.1158/1535-7163.MCT-11-0030

Preclinical Development

  • Preclinical Development
    Targeting the Mitochondria Activates Two Independent Cell Death Pathways in Ovarian Cancer Stem Cells
    Ayesha B. Alvero, Michele K. Montagna, Jennie C. Holmberg, Vinicius Craveiro, David Brown and Gil Mor
    Mol Cancer Ther August 1 2011 10 (8) 1385-1393; DOI:10.1158/1535-7163.MCT-11-0023

  • Preclinical Development | Free Article
    Preclinical Characterization of OSI-027, a Potent and Selective Inhibitor of mTORC1 and mTORC2: Distinct from Rapamycin
    Shripad V. Bhagwat, Prafulla C. Gokhale, Andrew P. Crew, Andy Cooke, Yan Yao, Christine Mantis, Jennifer Kahler, Jennifer Workman, Mark Bittner, Lorina Dudkin, David M. Epstein, Neil W. Gibson, Robert Wild, Lee D. Arnold, Peter J. Houghton and Jonathan A. Pachter
    Mol Cancer Ther August 1 2011 10 (8) 1394-1406; DOI:10.1158/1535-7163.MCT-10-1099

  • Preclinical Development
    Enhanced Efficacy of IGF1R Inhibition in Pediatric Glioblastoma by Combinatorial Targeting of PDGFRα/β
    Aleksandra Bielen, Lara Perryman, Gary M. Box, Melanie Valenti, Alexis de Haven Brandon, Vanessa Martins, Alexa Jury, Sergey Popov, Sharon Gowan, Sebastien Jeay, Florence I. Raynaud, Francesco Hofmann, Darren Hargrave, Suzanne A. Eccles and Chris Jones
    Mol Cancer Ther August 1 2011 10 (8) 1407-1418; DOI:10.1158/1535-7163.MCT-11-0205

  • Preclinical Development
    Peloruside- and Laulimalide-Resistant Human Ovarian Carcinoma Cells Have βI-Tubulin Mutations and Altered Expression of βII- and βIII-Tubulin Isotypes
    Arun Kanakkanthara, Anja Wilmes, Aurora O'Brate, Daniel Escuin, Ariane Chan, Ada Gjyrezi, Janet Crawford, Pisana Rawson, Bronwyn Kivell, Peter T. Northcote, Ernest Hamel, Paraskevi Giannakakou and John H. Miller
    Mol Cancer Ther August 1 2011 10 (8) 1419-1429; DOI:10.1158/1535-7163.MCT-10-1057

  • Preclinical Development
    Sodium Butyrate Inhibits the Self-Renewal Capacity of Endometrial Tumor Side-Population Cells by Inducing a DNA Damage Response
    Kiyoko Kato, Aya Kuhara, Tomoko Yoneda, Takafumi Inoue, Tomoka Takao, Tatsuhiro Ohgami, Li Dan, Ayumi Kuboyama, Soshi Kusunoki, Satoru Takeda and Norio Wake
    Mol Cancer Ther August 1 2011 10 (8) 1430-1439; DOI:10.1158/1535-7163.MCT-10-1062

  • Preclinical Development
    In Vivo Activity of Combined PI3K/mTOR and MEK Inhibition in a KrasG12D;Pten Deletion Mouse Model of Ovarian Cancer
    Kathryn M. Kinross, Daniel V. Brown, Margarete Kleinschmidt, Susan Jackson, James Christensen, Carleen Cullinane, Rodney J. Hicks, Ricky W. Johnstone and Grant A. McArthur
    Mol Cancer Ther August 1 2011 10 (8) 1440-1449; DOI:10.1158/1535-7163.MCT-11-0240

  • Preclinical Development
    Levels of p27 Sensitize to Dual PI3K/mTOR Inhibition
    Misu Lee, Marily Theodoropoulou, Jochen Graw, Federico Roncaroli, Maria Chiara Zatelli and Natalia S. Pellegata
    Mol Cancer Ther August 1 2011 10 (8) 1450-1459; DOI:10.1158/1535-7163.MCT-11-0188

  • Preclinical Development
    Combinatorial Effects of Lapatinib and Rapamycin in Triple-Negative Breast Cancer Cells
    Tongrui Liu, Rami Yacoub, LaTonia D. Taliaferro-Smith, Shi-Yong Sun, Tisheeka R. Graham, Ryan Dolan, Christine Lobo, Mourad Tighiouart, Lily Yang, Amy Adams and Ruth M. O'Regan
    Mol Cancer Ther August 1 2011 10 (8) 1460-1469; DOI:10.1158/1535-7163.MCT-10-0925

  • Preclinical Development
    Restitution of Tumor Suppressor MicroRNAs Using a Systemic Nanovector Inhibits Pancreatic Cancer Growth in Mice
    Dipankar Pramanik, Nathaniel R. Campbell, Collins Karikari, Raghu Chivukula, Oliver A. Kent, Joshua T. Mendell and Anirban Maitra
    Mol Cancer Ther August 1 2011 10 (8) 1470-1480; DOI:10.1158/1535-7163.MCT-11-0152

  • Preclinical Development
    Trabectedin and Its C Subunit Modified Analogue PM01183 Attenuate Nucleotide Excision Repair and Show Activity toward Platinum-Resistant Cells
    Daniele G. Soares, Miriana S. Machado, Céline J. Rocca, Virginie Poindessous, Djamila Ouaret, Alain Sarasin, Carlos M. Galmarini, João A.P. Henriques, Alexandre E. Escargueil and Annette K. Larsen
    Mol Cancer Ther August 1 2011 10 (8) 1481-1489; DOI:10.1158/1535-7163.MCT-11-0252

  • Preclinical Development
    Molecular and Cellular Pharmacology of the Novel Noncamptothecin Topoisomerase I Inhibitor Genz-644282
    Dhriti Sooryakumar, Thomas S. Dexheimer, Beverly A. Teicher and Yves Pommier
    Mol Cancer Ther August 1 2011 10 (8) 1490-1499; DOI:10.1158/1535-7163.MCT-10-1043

  • Preclinical Development
    Neutralizing Monoclonal Antibody to Periostin Inhibits Ovarian Tumor Growth and Metastasis
    Min Zhu, Romaine E. Saxton, Lillian Ramos, David D. Chang, Beth Y. Karlan, Judith C. Gasson and Dennis J. Slamon
    Mol Cancer Ther August 1 2011 10 (8) 1500-1508; DOI:10.1158/1535-7163.MCT-11-0046

Molecular Medicine in Practice

  • Molecular Medicine in Practice
    Rationally Designed Treatment for Solid Tumors with MAPK Pathway Activation: A Phase I Study of Paclitaxel and Bortezomib Using an Adaptive Dose-Finding Approach
    Janice M. Mehnert, Antoinette R. Tan, Rebecca Moss, Elizabeth Poplin, Mark N. Stein, Mika Sovak, Kelly Levinson, Hongxia Lin, Michael Kane, Murugesan Gounder, Yong Lin, Weichung Joe Shih, Eileen White, Eric H. Rubin and Vassiliki Karantza
    Mol Cancer Ther August 1 2011 10 (8) 1509-1519; DOI:10.1158/1535-7163.MCT-10-0944

  • Molecular Medicine in Practice
    Melanoma Prognosis: A REMARK-Based Systematic Review and Bioinformatic Analysis of Immunohistochemical and Gene Microarray Studies
    Sarah-Jane Schramm and Graham J. Mann
    Mol Cancer Ther August 1 2011 10 (8) 1520-1528; DOI:10.1158/1535-7163.MCT-10-0901

Correction

  • Correction
    Correction: Targeting Oncogenic ALK: A Promising Strategy for Cancer Treatment
    Mol Cancer Ther August 1 2011 10 (8) 1529-1529; DOI:10.1158/1535-7163.MCT-11-0504

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Molecular Cancer Therapeutics: 10 (8)
August 2011
Volume 10, Issue 8
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  • Enhanced Antitumor Effects by Chemical Modified IGb3 Analogues

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Molecular Cancer Therapeutics
eISSN: 1538-8514
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