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Molecular Cancer Therapeutics
Molecular Cancer Therapeutics
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About the Cover

Cover image

Cover image expansion

MCAK is a kinesin-related motor protein that stimulates microtubule depolymerization. It localizes to centrosomes and nuclei during interphase, and to spindle poles and chromosome centromeres during mitosis. The cover figure shows a mixture of non-transfected and FLAGMCAK expressing cells that were stained for DNA (blue), FLAG-MCAK (green), and tubulin (red). MCAK overexpression increased the frequency of microtubule detachment from centrosomes, reduced the amount of microtubule polymer, and caused cells to exit from mitosis without cytokinesis, thereby producing large multinucleated cells with few and fragmented microtubules. The microtubule stabilizing drug paclitaxel was able to counteract the effects of MCAK overproduction. For details, see the article by Ganguly and colleagues on page 929.

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Molecular Cancer Therapeutics: 10 (6)
June 2011
Volume 10, Issue 6
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Issue Highlights

  • Overexpression of Mitotic Centromere–Associated Kinesin Stimulates Microtubule Detachment and Confers Resistance to Paclitaxel
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Copyright © 2021 by the American Association for Cancer Research.

Molecular Cancer Therapeutics
eISSN: 1538-8514
ISSN: 1535-7163

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