Table of Contents

Therapeutic Discovery

• Therapeutic Discovery | Free Article

  hTERT Promotes Imatinib Resistance in Chronic Myeloid Leukemia Cells: Therapeutic Implications

  Laure Deville, Josette Hillion, Frédéric Pendino, Mona Samy, Eric Nguyen and Evelyne Ségal-Bendirdjian

  Mol Cancer Ther May 1 2011 10 (5) 711-719; DOI:10.1158/1535-7163.MCT-10-0979

  
  
• Therapeutic Discovery

  Modulation of Protein Phosphatase 2A Activity Alters Androgen-Independent Growth of Prostate Cancer Cells: Therapeutic Implications

  Arun Bhardwaj, Seema Singh, Sanjeev K. Srivastava, Richard E. Honkanen, Eddie Reed and Ajay P. Singh

  Mol Cancer Ther May 1 2011 10 (5) 720-731; DOI:10.1158/1535-7163.MCT-10-1096

  
  
• Therapeutic Discovery

  CCN1, a Candidate Target for Zoledronic Acid Treatment in Breast Cancer

  Ingrid Espinoza, Hong Liu, Robert Busby and Ruth Lupu

  Mol Cancer Ther May 1 2011 10 (5) 732-741; DOI:10.1158/1535-7163.MCT-10-0836

  
  
• Therapeutic Discovery

  A YKL-40–Neutralizing Antibody Blocks Tumor Angiogenesis and Progression: A Potential Therapeutic Agent in Cancers

  Michael Faibish, Ralph Francescone, Brooke Bentley, Wei Yan and Rong Shao

  Mol Cancer Ther May 1 2011 10 (5) 742-751; DOI:10.1158/1535-7163.MCT-10-0868

  
  
• Therapeutic Discovery

  Evaluating the Consistency of Differential Expression of MicroRNA Detected in Human Cancers

  Xue Gong, Ruihong Wu, Hongwei Wang, Xinwu Guo, Dong Wang, Yunyan Gu, Yuannv Zhang, Wenyuan Zhao, Lixin Cheng, Chenguang Wang and Zheng Guo

  Mol Cancer Ther May 1 2011 10 (5) 752-760; DOI:10.1158/1535-7163.MCT-10-0837

  
  
• Therapeutic Discovery

  Enhanced Chemotherapy of Cancer Using pH-Sensitive Mesoporous Silica Nanoparticles to Antagonize P-Glycoprotein–Mediated Drug Resistance

  I-Ping Huang, Shu-Pin Sun, Shih-Hsun Cheng, Chia-Hung Lee, Chia-Yan Wu, Chung-Shi Yang, Leu-Wei Lo and Yiu-Kay Lai

  Mol Cancer Ther May 1 2011 10 (5) 761-769; DOI:10.1158/1535-7163.MCT-10-0884

  
  
• Therapeutic Discovery

  An Antibody Targeted to VEGFR-2 Ig Domains 4-7 Inhibits VEGFR-2 Activation and VEGFR-2–Dependent Angiogenesis without Affecting Ligand Binding

  Jane Kendrew, Cath Eberlein, Brad Hedberg, Karen McDaid, Neil R. Smith, Hazel M. Weir, Stephen R. Wedge, David C. Blakey, Ian Foltz, Joe Zhou, Jaspal S. Kang and Simon T. Barry

  Mol Cancer Ther May 1 2011 10 (5) 770-783; DOI:10.1158/1535-7163.MCT-10-0876

  
  
• Therapeutic Discovery

  Determinants of Mitotic Catastrophe on Abrogation of the G₂ DNA Damage Checkpoint by UCN-01

  Kin Fan On, Yue Chen, Hoi Tang Ma, Jeremy P.H. Chow and Randy Y.C. Poon

  Mol Cancer Ther May 1 2011 10 (5) 784-794; DOI:10.1158/1535-7163.MCT-10-0809

  
  
• Therapeutic Discovery

  (−)-Gossypol Suppresses the Growth of Human Prostate Cancer Xenografts via Modulating VEGF Signaling–Mediated Angiogenesis

  Xiufeng Pang, Yuanyuan Wu, Yougen Wu, Binbin Lu, Jing Chen, Jieqiong Wang, Zhengfang Yi, Weijing Qu and Mingyao Liu

  Mol Cancer Ther May 1 2011 10 (5) 795-805; DOI:10.1158/1535-7163.MCT-10-0936

  
  
• Therapeutic Discovery

  Dependence on the MUC1-C Oncoprotein in Non–Small Cell Lung Cancer Cells

  Deepak Raina, Michio Kosugi, Rehan Ahmad, Govind Panchamoorthy, Hasan Rajabi, Maroof Alam, Takeshi Shimamura, Geoffrey I. Shapiro, Jeffrey Supko, Surender Kharbanda and Donald Kufe

  Mol Cancer Ther May 1 2011 10 (5) 806-816; DOI:10.1158/1535-7163.MCT-10-1050

  
  
• Therapeutic Discovery

  Antitumor Activity of the Hsp90 Inhibitor IPI-504 in HER2-Positive Trastuzumab-Resistant Breast Cancer

  Maurizio Scaltriti, Violeta Serra, Emmanuel Normant, Marta Guzman, Olga Rodriguez, Alice R. Lim, Kelly L. Slocum, Kip A. West, Varenka Rodriguez, Ludmila Prudkin, José Jimenez, Claudia Aura and José Baselga

  Mol Cancer Ther May 1 2011 10 (5) 817-824; DOI:10.1158/1535-7163.MCT-10-0966

  
  
• Therapeutic Discovery

  High-Throughput Screen Identifies Novel Inhibitors of Cancer Biomarker α-Methylacyl Coenzyme A Racemase (AMACR/P504S)

  Brice A.P. Wilson, Haofan Wang, Benjamin A. Nacev, Ronnie C. Mease, Jun O. Liu, Martin G. Pomper and William B. Isaacs

  Mol Cancer Ther May 1 2011 10 (5) 825-838; DOI:10.1158/1535-7163.MCT-10-0902