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Molecular Cancer Therapeutics
Molecular Cancer Therapeutics
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Table of Contents

Highlights

  • Highlights
    Highlights of This Issue
    Mol Cancer Ther May 1 2011 10 (5) 709-709;

Therapeutic Discovery

  • Therapeutic Discovery | Free Article
    hTERT Promotes Imatinib Resistance in Chronic Myeloid Leukemia Cells: Therapeutic Implications
    Laure Deville, Josette Hillion, Frédéric Pendino, Mona Samy, Eric Nguyen and Evelyne Ségal-Bendirdjian
    Mol Cancer Ther May 1 2011 10 (5) 711-719; DOI:10.1158/1535-7163.MCT-10-0979

  • Therapeutic Discovery
    Modulation of Protein Phosphatase 2A Activity Alters Androgen-Independent Growth of Prostate Cancer Cells: Therapeutic Implications
    Arun Bhardwaj, Seema Singh, Sanjeev K. Srivastava, Richard E. Honkanen, Eddie Reed and Ajay P. Singh
    Mol Cancer Ther May 1 2011 10 (5) 720-731; DOI:10.1158/1535-7163.MCT-10-1096

  • Therapeutic Discovery
    CCN1, a Candidate Target for Zoledronic Acid Treatment in Breast Cancer
    Ingrid Espinoza, Hong Liu, Robert Busby and Ruth Lupu
    Mol Cancer Ther May 1 2011 10 (5) 732-741; DOI:10.1158/1535-7163.MCT-10-0836

  • Therapeutic Discovery
    A YKL-40–Neutralizing Antibody Blocks Tumor Angiogenesis and Progression: A Potential Therapeutic Agent in Cancers
    Michael Faibish, Ralph Francescone, Brooke Bentley, Wei Yan and Rong Shao
    Mol Cancer Ther May 1 2011 10 (5) 742-751; DOI:10.1158/1535-7163.MCT-10-0868

  • Therapeutic Discovery
    Evaluating the Consistency of Differential Expression of MicroRNA Detected in Human Cancers
    Xue Gong, Ruihong Wu, Hongwei Wang, Xinwu Guo, Dong Wang, Yunyan Gu, Yuannv Zhang, Wenyuan Zhao, Lixin Cheng, Chenguang Wang and Zheng Guo
    Mol Cancer Ther May 1 2011 10 (5) 752-760; DOI:10.1158/1535-7163.MCT-10-0837

  • Therapeutic Discovery
    Enhanced Chemotherapy of Cancer Using pH-Sensitive Mesoporous Silica Nanoparticles to Antagonize P-Glycoprotein–Mediated Drug Resistance
    I-Ping Huang, Shu-Pin Sun, Shih-Hsun Cheng, Chia-Hung Lee, Chia-Yan Wu, Chung-Shi Yang, Leu-Wei Lo and Yiu-Kay Lai
    Mol Cancer Ther May 1 2011 10 (5) 761-769; DOI:10.1158/1535-7163.MCT-10-0884

  • Therapeutic Discovery
    An Antibody Targeted to VEGFR-2 Ig Domains 4-7 Inhibits VEGFR-2 Activation and VEGFR-2–Dependent Angiogenesis without Affecting Ligand Binding
    Jane Kendrew, Cath Eberlein, Brad Hedberg, Karen McDaid, Neil R. Smith, Hazel M. Weir, Stephen R. Wedge, David C. Blakey, Ian Foltz, Joe Zhou, Jaspal S. Kang and Simon T. Barry
    Mol Cancer Ther May 1 2011 10 (5) 770-783; DOI:10.1158/1535-7163.MCT-10-0876

  • Therapeutic Discovery
    Determinants of Mitotic Catastrophe on Abrogation of the G2 DNA Damage Checkpoint by UCN-01
    Kin Fan On, Yue Chen, Hoi Tang Ma, Jeremy P.H. Chow and Randy Y.C. Poon
    Mol Cancer Ther May 1 2011 10 (5) 784-794; DOI:10.1158/1535-7163.MCT-10-0809

  • Therapeutic Discovery
    (−)-Gossypol Suppresses the Growth of Human Prostate Cancer Xenografts via Modulating VEGF Signaling–Mediated Angiogenesis
    Xiufeng Pang, Yuanyuan Wu, Yougen Wu, Binbin Lu, Jing Chen, Jieqiong Wang, Zhengfang Yi, Weijing Qu and Mingyao Liu
    Mol Cancer Ther May 1 2011 10 (5) 795-805; DOI:10.1158/1535-7163.MCT-10-0936

  • Therapeutic Discovery
    Dependence on the MUC1-C Oncoprotein in Non–Small Cell Lung Cancer Cells
    Deepak Raina, Michio Kosugi, Rehan Ahmad, Govind Panchamoorthy, Hasan Rajabi, Maroof Alam, Takeshi Shimamura, Geoffrey I. Shapiro, Jeffrey Supko, Surender Kharbanda and Donald Kufe
    Mol Cancer Ther May 1 2011 10 (5) 806-816; DOI:10.1158/1535-7163.MCT-10-1050

  • Therapeutic Discovery
    Antitumor Activity of the Hsp90 Inhibitor IPI-504 in HER2-Positive Trastuzumab-Resistant Breast Cancer
    Maurizio Scaltriti, Violeta Serra, Emmanuel Normant, Marta Guzman, Olga Rodriguez, Alice R. Lim, Kelly L. Slocum, Kip A. West, Varenka Rodriguez, Ludmila Prudkin, José Jimenez, Claudia Aura and José Baselga
    Mol Cancer Ther May 1 2011 10 (5) 817-824; DOI:10.1158/1535-7163.MCT-10-0966

  • Therapeutic Discovery
    High-Throughput Screen Identifies Novel Inhibitors of Cancer Biomarker α-Methylacyl Coenzyme A Racemase (AMACR/P504S)
    Brice A.P. Wilson, Haofan Wang, Benjamin A. Nacev, Ronnie C. Mease, Jun O. Liu, Martin G. Pomper and William B. Isaacs
    Mol Cancer Ther May 1 2011 10 (5) 825-838; DOI:10.1158/1535-7163.MCT-10-0902

Preclinical Development

  • Preclinical Development
    Caspase-3–Dependent Mitotic Checkpoint Inactivation by the Small-Molecule Inducers of Mitotic Slippage SU6656 and Geraldol
    Jenna L. Riffell, Reiner U. Jänicke and Michel Roberge
    Mol Cancer Ther May 1 2011 10 (5) 839-849; DOI:10.1158/1535-7163.MCT-10-0909

  • Preclinical Development
    A Human Model of Epithelial to Mesenchymal Transition to Monitor Drug Efficacy in Hepatocellular Carcinoma Progression
    Franziska van Zijl, Sabine Mall, Georg Machat, Christine Pirker, Robert Zeillinger, Andreas Weinhaeusel, Martin Bilban, Walter Berger and Wolfgang Mikulits
    Mol Cancer Ther May 1 2011 10 (5) 850-860; DOI:10.1158/1535-7163.MCT-10-0917

  • Preclinical Development
    Assessing the Activity of Cediranib, a VEGFR-2/3 Tyrosine Kinase Inhibitor, against VEGFR-1 and Members of the Structurally Related PDGFR Family
    Sandra R. Brave, Kirsty Ratcliffe, Zena Wilson, Neil H. James, Sue Ashton, Anna Wainwright, Jane Kendrew, Philippa Dudley, Nicola Broadbent, Graham Sproat, Sian Taylor, Claire Barnes, Jeffrey C. Silva, Charles L. Farnsworth, Laurent Hennequin, Donald J. Ogilvie, Juliane M. Jürgensmeier, Masabumi Shibuya, Stephen R. Wedge and Simon T. Barry
    Mol Cancer Ther May 1 2011 10 (5) 861-873; DOI:10.1158/1535-7163.MCT-10-0976

  • Preclinical Development
    2-Methoxyestradiol Analogue ENMD-1198 Reduces Breast Cancer-Induced Osteolysis and Tumor Burden Both In Vitro and In Vivo
    Thomas J.A. Snoeks, Isabel M. Mol, Ivo Que, Eric L. Kaijzel and Clemens W.G.M. Löwik
    Mol Cancer Ther May 1 2011 10 (5) 874-882; DOI:10.1158/1535-7163.MCT-10-0997

  • Preclinical Development
    Curcumin Inhibition of the Functional Interaction between Integrin α6β4 and the Epidermal Growth Factor Receptor
    Young Hwa Soung and Jun Chung
    Mol Cancer Ther May 1 2011 10 (5) 883-891; DOI:10.1158/1535-7163.MCT-10-1053

  • Preclinical Development
    Bortezomib Sensitizes HCC Cells to CS-1008, an Antihuman Death Receptor 5 Antibody, through the Inhibition of CIP2A
    Kuen-Feng Chen, Hui-Chuan Yu, Chun-Yu Liu, Hui-Ju Chen, Yi-Ching Chen, Duen-Ren Hou, Pei-Jer Chen and Ann-Lii Cheng
    Mol Cancer Ther May 1 2011 10 (5) 892-901; DOI:10.1158/1535-7163.MCT-10-0794

  • Preclinical Development
    Therapeutic Potential and Molecular Mechanism of a Novel, Potent, Nonpeptide, Smac Mimetic SM-164 in Combination with TRAIL for Cancer Treatment
    Jianfeng Lu, Donna McEachern, Haiying Sun, Longchuan Bai, Yuefeng Peng, Su Qiu, Rebecca Miller, Jinhui Liao, Han Yi, Meilan Liu, Anita Bellail, Chunhai Hao, Shi-Yong Sun, Adrian T. Ting and Shaomeng Wang
    Mol Cancer Ther May 1 2011 10 (5) 902-914; DOI:10.1158/1535-7163.MCT-10-0864

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Molecular Cancer Therapeutics: 10 (5)
May 2011
Volume 10, Issue 5
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Issue Highlights

  • A Human Model of Epithelial to Mesenchymal Transition to Monitor Drug Efficacy in Hepatocellular Carcinoma Progression

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Molecular Cancer Therapeutics
eISSN: 1538-8514
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