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Molecular Cancer Therapeutics
Molecular Cancer Therapeutics
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About the Cover

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The Cover

cDNA microarray analysis of HeLa S3 cells treated with the G-quadruplex-interactive cationic porphyrin TMPyP4. Cells were treated with 100 µm TMPyP4 for 48 h, and mRNA was used to probe a 500-gene array. The expression of a number of oncogenes, including c-FOS, JUN-B, c-MYB, STAT-1, and c-MYC, was decreased specifically by this agent, and not by its positional isomer TMPyP2, which interacts with G-quadruplex DNA very poorly. The c-MYC oncogene is one of the most consistently down-regulated genes in this study and bears a sequence in its promoter that forms a G-quadruplex structure in vitro. For details, see 565 in this issue.

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Molecular Cancer Therapeutics: 1 (8)
June 2002
Volume 1, Issue 8
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Issue Highlights

  • The Cationic Porphyrin TMPyP4 Down-Regulates c-MYC and Human Telomerase Reverse Transcriptase Expression and Inhibits Tumor Growth in Vivo 1 This research was supported by grants from the NIH and the Arizona Disease Control Research Commission.1
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Copyright © 2021 by the American Association for Cancer Research.

Molecular Cancer Therapeutics
eISSN: 1538-8514
ISSN: 1535-7163

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