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February 2020
Read the February 2020 issue!
10D1F, an Anti-HER3 Antibody that Uniquely Blocks the Receptor Heterodimerization Interface, Potently Inhibits Tumor Growth Across a Broad Panel of Tumor Models
Dipti Thakkar, et al.
ERK Inhibitor LY3214996 Targets ERK Pathway–Driven Cancers: A Therapeutic Approach Toward Precision Medicine
Shripad V. Bhagwat, et al.
Targeting of β-Catenin Reverses Radioresistance of Cervical Cancer with the PIK3CA-E545K Mutation
Wei Jiang, et al.

From the Current Issue

Small Molecule Therapeutics | AuthorChoice

ERK Inhibitor LY3214996 Targets ERK Pathway–Driven Cancers: A Therapeutic Approach Toward Precision Medicine

Shripad V. Bhagwat, William T. McMillen, Shufen Cai, Baohui Zhao, Matthew Whitesell, Weihua Shen, Lisa Kindler, Robert S. Flack, Wenjuan Wu, Bryan Anderson, Yan Zhai, Xiu-Juan Yuan, Meghann Pogue, Robert D. Van Horn, Xi Rao, Denis McCann, Andrew J. Dropsey, Jason Manro, Jennie Walgren, Eunice Yuen, Michael J. Rodriguez, Gregory D. Plowman, Ramon V. Tiu, Sajan Joseph and Sheng-Bin Peng

Mol Cancer Ther February 1 2020 19 (2) 325-336; DOI:10.1158/1535-7163.MCT-19-0183
Large Molecule Therapeutics

10D1F, an Anti-HER3 Antibody That Uniquely Blocks the Receptor Heterodimerization Interface, Potently Inhibits Tumor Growth Across a Broad Panel of Tumor Models

Dipti Thakkar, Vicente Sancenon, Marvin M. Taguiam, Siyu Guan, Zhihao Wu, Eric Ng, Konrad H. Paszkiewicz, Piers J. Ingram and Jerome D. Boyd-Kirkup

Mol Cancer Ther February 1 2020 19 (2) 490-501; DOI:10.1158/1535-7163.MCT-19-0515
Cancer Biology and Translational Studies | AuthorChoice

Dual-Mechanism ERK1/2 Inhibitors Exploit a Distinct Binding Mode to Block Phosphorylation and Nuclear Accumulation of ERK1/2

Andrew M. Kidger, Joanne M. Munck, Harpreet K. Saini, Kathryn Balmanno, Emma Minihane, Aurelie Courtin, Brent Graham, Marc O'Reilly, Richard Odle and Simon J. Cook

Mol Cancer Ther February 1 2020 19 (2) 525-539; DOI:10.1158/1535-7163.MCT-19-0505
Companion Diagnostic, Pharmacogenomic, and Cancer Biomarkers

PET Imaging of the EPR Effect in Tumor Xenografts Using Small 15 nm Diameter Polyethylene Glycols Labeled with Zirconium-89

Denis R. Beckford Vera, Shaun D. Fontaine, Henry F. VanBrocklin, Brian R. Hearn, Ralph Reid, Gary W. Ashley and Daniel V. Santi

Mol Cancer Ther February 1 2020 19 (2) 673-679; DOI:10.1158/1535-7163.MCT-19-0709
Models and Technologies

Therapeutic Breast Reconstruction Using Gene Therapy–Delivered IFNγ Immunotherapy

Christopher R. Davis, Peter A. Than, Sacha M.L. Khong, Melanie Rodrigues, Michael W. Findlay, Daniel J. Navarrete, Shadi Ghali, Jayant S. Vaidya and Geoffrey C. Gurtner

Mol Cancer Ther February 1 2020 19 (2) 697-705; DOI:10.1158/1535-7163.MCT-19-0315

See the Table of Contents

Recent Reviews

Review

The Ongoing Search for Biomarkers of CDK4/6 Inhibitor Responsiveness in Breast Cancer

Scott F. Schoninger and Stacy W. Blain

Mol Cancer Ther January 1 2020 19 (1) 3-12; DOI:10.1158/1535-7163.MCT-19-0253
Review | AuthorChoice

Cabozantinib in Combination with Immunotherapy for Advanced Renal Cell Carcinoma and Urothelial Carcinoma: Rationale and Clinical Evidence

Paulo Bergerot, Peter Lamb, Evelyn Wang and Sumanta K. Pal

Mol Cancer Ther December 1 2019 18 (12) 2185-2193; DOI:10.1158/1535-7163.MCT-18-1399
Reviews | AuthorChoice

ATM Dysfunction in Pancreatic Adenocarcinoma and Associated Therapeutic Implications

Samantha A. Armstrong, Christopher W. Schultz, Ariana Azimi-Sadjadi, Jonathan R. Brody and Michael J. Pishvaian

Mol Cancer Ther November 1 2019 18 (11) 1899-1908; DOI:10.1158/1535-7163.MCT-19-0208
Reviews

Targeting the EGFR and Immune Pathways in Squamous Cell Carcinoma of the Head and Neck (SCCHN): Forging a New Alliance

Nabil F. Saba, Zhuo Gerogia Chen, Missak Haigentz, Paolo Bossi, Alessandra Rinaldo, Juan P. Rodrigo, Antti A. Mäkitie, Robert P. Takes, Primoz Strojan, Jan B. Vermorken and Alfio Ferlito

Mol Cancer Ther November 1 2019 18 (11) 1909-1915; DOI:10.1158/1535-7163.MCT-19-0214

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