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Read the October 2019 issue!
Cover image from "Tyrosine Threonine Kinase Inhibition Eliminates Lung Cancers by Augmenting Apoptosis and Polyploidy" by Zheng and colleagues.
Patient-Focused Therapies in Breast Cancer Collection.
As we move into October, Breast Cancer Awareness Month, read our new Patient-Focused Therapies in Breast Cancer Collection.
Countering Breast Cancer's Counterpunch
Brion W. Murray
New Review: Metabolic Flexibility in Cancer: Targeting the Pyruvate Dehydrogenase Kinase:Pyruvate Dehydrogenase Axis
Benjamin L. Woolbright, et al.

From the Current Issue

Review

Metabolic Flexibility in Cancer: Targeting the Pyruvate Dehydrogenase Kinase:Pyruvate Dehydrogenase Axis

Benjamin L. Woolbright, Ganeshkumar Rajendran, Robert A. Harris and John A. Taylor III

Mol Cancer Ther October 1 2019 18 (10) 1673-1681; DOI:10.1158/1535-7163.MCT-19-0079
Patient Focused Therapies in Breast Cancer | AuthorChoice

Suppression of Nuclear Factor-κB by Glucocorticoid Receptor Blocks Estrogen-Induced Apoptosis in Estrogen-Deprived Breast Cancer Cells

Ping Fan, Doris R. Siwak, Balkees Abderrahman, Fadeke A. Agboke, Smitha Yerrum and V. Craig Jordan

Mol Cancer Ther October 1 2019 18 (10) 1684-1695; DOI:10.1158/1535-7163.MCT-18-1363
Small Molecule Therapeutics

Specific RITA Modification Produces Hyperselective Cytotoxicity While Maintaining In Vivo Antitumor Efficacy

Brian D. Peyser, Ann Hermone, Joseph M. Salamoun, James C. Burnett, Melinda G. Hollingshead, Connor F. McGrath, Rick Gussio and Peter Wipf

Mol Cancer Ther October 1 2019 18 (10) 1765-1774; DOI:10.1158/1535-7163.MCT-19-0185
Large Molecule Therapeutics

Preclinical Development of U3-1784, a Novel FGFR4 Antibody Against Cancer, and Avoidance of Its On-target Toxicity

René Bartz, Keisuke Fukuchi, Toshiaki Ohtsuka, Tanja Lange, Katrin Gruner, Ichiro Watanabe, Shinko Hayashi, Yoko Oda, Reimi Kawaida, Hironobu Komori, Yoshinori Kashimoto, Peter Wirtz, Jan-Peter A. Mayer, Mauricio Redondo-Müller, Shuntaro Saito, Mizuki Takahashi, Hiroyuki Hanzawa, Emi Imai, Alberto Martinez, Masaharu Hanai, Dieter Häussinger, Roger W. Chapman, Toshinori Agatsuma, Johannes Bange and Reimar Abraham

Mol Cancer Ther October 1 2019 18 (10) 1832-1843; DOI:10.1158/1535-7163.MCT-18-0048
Companion Diagnostic, Pharmacogenomic, and Cancer Biomarkers

Serum PD-1 Is Elevated after Pembrolizumab Treatment but Has No Predictive Value

Milena Music, Marco A.J. Iafolla, Annie He Ren, Antoninus Soosaipillai, Ioannis Prassas and Eleftherios P. Diamandis

Mol Cancer Ther October 1 2019 18 (10) 1844-1851; DOI:10.1158/1535-7163.MCT-19-0132

See the Table of Contents

Recent Reviews

Review | AuthorChoice

DUBbing Down Translation: The Functional Interaction of Deubiquitinases with the Translational Machinery

Bandish B. Kapadia and Ronald B. Gartenhaus

Mol Cancer Ther September 1 2019 18 (9) 1475-1483; DOI:10.1158/1535-7163.MCT-19-0307
Review

What CAR Will Win the CD19 Race?

Alfonso Quintás-Cardama

Mol Cancer Ther March 1 2019 18 (3) 498-506; DOI:10.1158/1535-7163.MCT-18-1070
Reviews

Shedding Light on the Dark Cancer Genomes: Long Noncoding RNAs as Novel Biomarkers and Potential Therapeutic Targets for Cancer

Lin Zhang, Dan Peng, Anil K. Sood, Chi V. Dang and Xiaomin Zhong

Mol Cancer Ther September 1 2018 17 (9) 1816-1823; DOI:10.1158/1535-7163.MCT-18-0124
Reviews

We're Not “DON” Yet: Optimal Dosing and Prodrug Delivery of 6-Diazo-5-oxo-L-norleucine

Kathryn M. Lemberg, James J. Vornov, Rana Rais and Barbara S. Slusher

Mol Cancer Ther September 1 2018 17 (9) 1824-1832; DOI:10.1158/1535-7163.MCT-17-1148

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