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Molecular Cancer Therapeutics

Molecular Cancer Therapeutics

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The AACR remains fully committed to supporting publishing operations throughout this challenging time, while still remaining flexible and supportive of the author, reviewer, and editor communities that we serve. If you have any questions or concerns, please reach out to a member of the AACR publishing staff.
Please visit the COVID-19 & Cancer Resource Center where COVID-related content is freely available.

 

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  • Current cover for Molecular Cancer Therapeutics
    January 2021
    Read the January issue!
  • Repurposing the Antidepressant Sertraline as SHMT Inhibitor to Suppress Serine/Glycine Synthesis–Addicted Breast Tumor Growth
    Repurposing the Antidepressant Sertraline as SHMT Inhibitor to Suppress Serine/Glycine Synthesis–Addicted Breast Tumor Growth
    Shauni Lien Geeraerts, et al.
  • Review: Targeting PIM Kinases to Overcome Therapeutic Resistance in Cancer
    Review: Targeting PIM Kinases to Overcome Therapeutic Resistance in Cancer
    Rachel K. Toth and Noel A. Warfel
  • Heat Shock Protein-90 Inhibition Alters Activation of Pancreatic Stellate Cells and Enhances the Efficacy of PD-1 Blockade in Pancreatic Cancer
    Heat Shock Protein-90 Inhibition Alters Activation of Pancreatic Stellate Cells and Enhances the Efficacy of PD-1 Blockade in Pancreatic Cancer
    Yuchen Zhang, et al.
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From the Current Issue

  • Review
    Targeting PIM Kinases to Overcome Therapeutic Resistance in Cancer
    Rachel K. Toth and Noel A. Warfel
    Mol Cancer Ther January 1 2021 20 (1) 3-10; DOI:10.1158/1535-7163.MCT-20-0535

  • Small Molecule Therapeutics
    Rapid Induction of the Unfolded Protein Response and Apoptosis by Estrogen Mimic TTC-352 for the Treatment of Endocrine-Resistant Breast Cancer
    Balkees Abderrahman, Philipp Y. Maximov, Ramona F. Curpan, Sean W. Fanning, Jay S. Hanspal, Ping Fan, Charles E. Foulds, Yue Chen, Anna Malovannaya, Antrix Jain, Rui Xiong, Geoffrey L. Greene, Debra A. Tonetti, Gregory R.J. Thatcher and V. Craig Jordan
    Mol Cancer Ther January 1 2021 20 (1) 11-25; DOI:10.1158/1535-7163.MCT-20-0563

  • Large Molecule Therapeutics | AuthorChoice
    Selective Tumor Cell Apoptosis and Tumor Regression in CDH17-Positive Colorectal Cancer Models using BI 905711, a Novel Liver-Sparing TRAILR2 Agonist
    Juan Manuel García-Martínez, Shirley Wang, Cordula Weishaeupl, Andreas Wernitznig, Paolo Chetta, Catarina Pinto, Jason Ho, Darrin Dutcher, Philip N. Gorman, Rachel Kroe-Barrett, Joerg Rinnenthal, Craig Giragossian, Maria Antonietta Impagnatiello, Iñigo Tirapu, Frank Hilberg, Norbert Kraut, Mark Pearson and Klaus Peter Kuenkele
    Mol Cancer Ther January 1 2021 20 (1) 96-108; DOI:10.1158/1535-7163.MCT-20-0253

  • Companion Diagnostic, Pharmacogenomic, and Cancer Biomarkers | AuthorChoice
    Circulating Tumor Cells and Biomarker Modulation with Olaratumab Monotherapy Followed by Olaratumab plus Doxorubicin: Phase Ib Study in Patients with Soft-Tissue Sarcoma
    Javier Martín-Broto, Antonio López Pousa, Andrew S. Brohl, Brian A. Van Tine, Benjamin Powers, Silvia Stacchiotti, Jean-Yves Blay, James S. Hu, Gerard J. Oakley III, Hong Wang, Anna M. Szpurka, Donna E. Levy, Gary Mo, Matteo Ceccarelli and Robin L. Jones
    Mol Cancer Ther January 1 2021 20 (1) 132-141; DOI:10.1158/1535-7163.MCT-20-0441

  • Cancer Biology and Translational Studies
    Heat Shock Protein-90 Inhibition Alters Activation of Pancreatic Stellate Cells and Enhances the Efficacy of PD-1 Blockade in Pancreatic Cancer
    Yuchen Zhang, Michael B. Ware, Mohammad Y. Zaidi, Amanda N. Ruggieri, Brian M. Olson, Hannah Komar, Matthew R. Farren, Ganji Purnachandra Nagaraju, Chao Zhang, Zhengjia Chen, Juan M. Sarmiento, Rafi Ahmed, Shishir K. Maithel, Bassel F. El-Rayes and Gregory B. Lesinski
    Mol Cancer Ther January 1 2021 20 (1) 150-160; DOI:10.1158/1535-7163.MCT-19-0911

  • Models and Technologies | AuthorChoice
    Antibody Co-Administration Can Improve Systemic and Local Distribution of Antibody–Drug Conjugates to Increase In Vivo Efficacy
    Jose F. Ponte, Leanne Lanieri, Eshita Khera, Rassol Laleau, Olga Ab, Christopher Espelin, Neeraj Kohli, Bahar Matin, Yulius Setiady, Michael L. Miller, Thomas A. Keating, Ravi Chari, Jan Pinkas, Richard Gregory and Greg M. Thurber
    Mol Cancer Ther January 1 2021 20 (1) 203-212; DOI:10.1158/1535-7163.MCT-20-0451

See the Table of Contents


Recent Reviews

  • Review | AuthorChoice
    Therapeutic Targeting of Mitochondrial One-Carbon Metabolism in Cancer
    Aamod S. Dekhne, Zhanjun Hou, Aleem Gangjee and Larry H. Matherly
    Mol Cancer Ther November 1 2020 19 (11) 2245-2255; DOI:10.1158/1535-7163.MCT-20-0423

  • Review
    Ion Channels and Their Role in the Pathophysiology of Gliomas
    Takeshi Takayasu, Kaoru Kurisu, Yoshua Esquenazi and Leomar Y. Ballester
    Mol Cancer Ther October 1 2020 19 (10) 1959-1969; DOI:10.1158/1535-7163.MCT-19-0929

  • Reviews
    Allosteric Inhibition of ABL Kinases: Therapeutic Potential in Cancer
    Jill K. Jones and Eric M. Thompson
    Mol Cancer Ther September 1 2020 19 (9) 1763-1769; DOI:10.1158/1535-7163.MCT-20-0069

  • Reviews | AuthorChoice
    Patient Selection Strategies to Maximize Therapeutic Index of Antibody–Drug Conjugates: Prior Approaches and Future Directions
    Marna Williams, Anna Spreafico, Kapil Vashisht and Mary Jane Hinrichs
    Mol Cancer Ther September 1 2020 19 (9) 1770-1783; DOI:10.1158/1535-7163.MCT-19-0993

OnlineFirst Articles

  • Efficacy of Rigosertib in Rhabdomyosarcoma and Neuroblastoma
    Joshua T. Kowalczyk, et al.
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    Vikki Flemington, et al.
  • Targeting STAT3 with PROTACs and Next-Generation ASOs
    Jamie V. Shiah, et al.
  • Galunisertib and SBRT in Patients with Advanced HCC
    Kim A. Reiss, et al.
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Molecular Cancer Therapeutics
eISSN: 1538-8514
ISSN: 1535-7163

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