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Read the November 2019 issue!
Cover image from "Tumor Priming by SMO Inhibition Enhances Antibody Delivery and Efficacy in a Pancreatic Ductal Adenocarcinoma Model" by Wang and colleagues.
Targeting First Disclosures in Cancer Therapeutics
MCT announces our commitment to initial disclosures, including first publication of the structure of new chemical entities. This collection highlights several first disclosures published in MCT.
First-in-Class Phosphorylated-p68 Inhibitor RX-5902 Inhibits β-Catenin Signaling and Demonstrates Antitumor Activity in Triple-Negative Breast Cancer
Anna Capasso, et al.
New Review: ATM Dysfunction in Pancreatic Adenocarcinoma and Associated Therapeutic Implications
Samantha A. Armstrong, et al.
New Review: Targeting the EGFR and Immune Pathways in Squamous Cell Carcinoma of the Head and Neck (SCCHN): Forging a New Alliance
Nabil F. Saba, et al.

From the Current Issue

Reviews | AuthorChoice

ATM Dysfunction in Pancreatic Adenocarcinoma and Associated Therapeutic Implications

Samantha A. Armstrong, Christopher W. Schultz, Ariana Azimi-Sadjadi, Jonathan R. Brody and Michael J. Pishvaian

Mol Cancer Ther November 1 2019 18 (11) 1899-1908; DOI:10.1158/1535-7163.MCT-19-0208
Small Molecule Therapeutics

First-in-Class Phosphorylated-p68 Inhibitor RX-5902 Inhibits β-Catenin Signaling and Demonstrates Antitumor Activity in Triple-Negative Breast Cancer

Anna Capasso, Stacey M. Bagby, Kyrie L. Dailey, Naomi Currimjee, Betelehem W. Yacob, Anastasia Ionkina, Julie G. Frank, Deog Joong Kim, Christina George, Young B. Lee, Ely Benaim, Brian Gittleman, Sarah J. Hartman, Aik Choon Tan, Jihye Kim, Todd M. Pitts, S. Gail Eckhardt, John J. Tentler and Jennifer R. Diamond

Mol Cancer Ther November 1 2019 18 (11) 1916-1925; DOI:10.1158/1535-7163.MCT-18-1334
Large Molecule Therapeutics

Preclinical Efficacy and Safety Comparison of CD3 Bispecific and ADC Modalities Targeting BCMA for the Treatment of Multiple Myeloma

Siler H. Panowski, Tracy C. Kuo, Yi Zhang, Amy Chen, Tao Geng, Laura Aschenbrenner, Cris Kamperschroer, Edward Pascua, Wei Chen, Kathy Delaria, Santiago Farias, Marjorie Bateman, Russell G. Dushin, Sherman M. Chin, Thomas J. Van Blarcom, Yik Andy Yeung, Kevin C. Lindquist, Allison G. Chunyk, Bing Kuang, Bora Han, Michael Mirsky, Ingrid Pardo, Bernard Buetow, Thomas G. Martin, Jeffrey L. Wolf, David Shelton, Arvind Rajpal, Pavel Strop, Javier Chaparro-Riggers and Barbra J. Sasu

Mol Cancer Ther November 1 2019 18 (11) 2008-2020; DOI:10.1158/1535-7163.MCT-19-0007
Cancer Biology and Translational Studies

PARP1 Inhibition Radiosensitizes Models of Inflammatory Breast Cancer to Ionizing Radiation

Anna R. Michmerhuizen, Andrea M. Pesch, Leah Moubadder, Benjamin C. Chandler, Kari Wilder-Romans, Meleah Cameron, Eric Olsen, Dafydd G. Thomas, Amanda Zhang, Nicole Hirsh, Cassandra L. Ritter, Meilan Liu, Shyam Nyati, Lori J. Pierce, Reshma Jagsi and Corey Speers

Mol Cancer Ther November 1 2019 18 (11) 2063-2073; DOI:10.1158/1535-7163.MCT-19-0520
Models and Technologies

Improved Drug Delivery to Brain Metastases by Peptide-Mediated Permeabilization of the Blood–Brain Barrier

Synnøve Nymark Aasen, Heidi Espedal, Christopher Florian Holte, Olivier Keunen, Tine Veronika Karlsen, Olav Tenstad, Zaynah Maherally, Hrvoje Miletic, Tuyen Hoang, Anne Vaag Eikeland, Habib Baghirov, Dag Erlend Olberg, Geoffrey John Pilkington, Gobinda Sarkar, Robert B. Jenkins, Terje Sundstrøm, Rolf Bjerkvig and Frits Thorsen

Mol Cancer Ther November 1 2019 18 (11) 2171-2181; DOI:10.1158/1535-7163.MCT-19-0160

See the Table of Contents

Recent Reviews

Review

Metabolic Flexibility in Cancer: Targeting the Pyruvate Dehydrogenase Kinase:Pyruvate Dehydrogenase Axis

Benjamin L. Woolbright, Ganeshkumar Rajendran, Robert A. Harris and John A. Taylor III

Mol Cancer Ther October 1 2019 18 (10) 1673-1681; DOI:10.1158/1535-7163.MCT-19-0079
Review | AuthorChoice

DUBbing Down Translation: The Functional Interaction of Deubiquitinases with the Translational Machinery

Bandish B. Kapadia and Ronald B. Gartenhaus

Mol Cancer Ther September 1 2019 18 (9) 1475-1483; DOI:10.1158/1535-7163.MCT-19-0307
Review

What CAR Will Win the CD19 Race?

Alfonso Quintás-Cardama

Mol Cancer Ther March 1 2019 18 (3) 498-506; DOI:10.1158/1535-7163.MCT-18-1070
Reviews

Shedding Light on the Dark Cancer Genomes: Long Noncoding RNAs as Novel Biomarkers and Potential Therapeutic Targets for Cancer

Lin Zhang, Dan Peng, Anil K. Sood, Chi V. Dang and Xiaomin Zhong

Mol Cancer Ther September 1 2018 17 (9) 1816-1823; DOI:10.1158/1535-7163.MCT-18-0124

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