Table 1.

Mitochondrial basal respiration, maximal respiratory capacity, respiratory reserve, and the IC50 for metformin for each of the 22 cancer cell lines of 7 different tissue origins

IC50 of metforminOxygen consumption rate (pmol O2/s/million cells)
(mmol/L)Basal mito. resp.Max. resp. capacityResp. reserve
Cancer cell linesMeanSDMeanSDMeanSDMeanSD
Lung
 H12996.00.647.313.597.315.050.03.1
 PC91.10.738.010.566.914.428.92.6
 H4603.91.224.97.444.35.622.23.6
 H5221.50.911.54.419.56.28.03.9
Pancreas
 HPAFII3.31.219.13.456.85.737.65.0
 PANC11.20.836.16.360.10.920.83.4
 Miapaca0.40.117.04.325.28.68.26.0
Breast
 MCF75.50.830.45.388.213.457.810.0
 MDAMB4362.30.220.77.862.314.741.68.1
 MDAMB2311.81.77.93.537.85.429.92.9
Colon
 Colo20513.02.333.75.8109.06.480.43.4
 HT293.21.29.94.338.11.428.23.6
 HCT154.80.818.86.442.67.423.84.0
 HCT1162.70.929.76.856.64.620.95.2
Liver
 HepG27.00.952.70.7114.07.961.27.2
 Huh70.60.633.21.857.70.524.52.3
Melanoma
 SK-Me1287.60.244.76.2152.419.2107.314.1
 UACC628.32.136.60.7120.415.783.815.3
 SK-Mel27.80.731.72.979.04.148.12.2
 M146.00.427.33.672.710.645.57.1
Ovary
 Sn12C2.00.914.82.054.17.139.74.4
 OVCAR-81.50.710.23.925.58.915.38.5