Table 2.

In vitro cytotoxicity of MORAb-202 and eribulin on various FRA-positive cell lines

IC50
Cell lineCell line originFRA ExpressionMORAb-202Eribulin IC50
IGROV1Ovarian+++0.02 ± 0.000.28 ± 0.17
OVCAR-3Ovarian++0.75 ± 0.360.10 ± 0.03
CaOV3Ovarian++4.26 ± 0.530.44 ± 0.00
NCI-H2110NSCLC++0.42 ± 0.110.19 ± 0.01
MKN7Gastric++2.17 ± 0.910.18 ± 0.01
MKN74Gastric++1.76 ± 0.880.21 ± 0.02
NCI-N87Gastric+4.42 ± 0.110.21 ± 0.01
NUGC3Gastric±24.58 ± 4.410.14 ± 0.01
HEC-251Endometrial++13.15 ± 2.320.36 ± 0.03
HEC-1-AEndometrial++1.81 ± 0.210.24 ± 0.04
HEC-59Endometrial+1.03 ± 0.540.06 ± 0.02
HCC1954TNBC+1.42 ± 0.310.25 ± 0.01
A431Epidermoid>1000.78 ± 0.03
  • NOTE: Values are averages of at least three independent assays. +++, mean fluorescence intensity (MFI) > 500; ++, MFI 50–500; +, MFI 20–50; ± MFI 5–20; −, MFI < 5.