Table 1.

Pevonedistat enhances radiation sensitivity of HNSCC cells

Cell linePevonedistat (nmol/L)αβSSF4SERP
Cal27DMSO2.03E−160.0350.18.0741<0.0001
201.50E−130.0490.16.8931.171<0.0001
400.1080.0520.15.6921.419<0.0001
600.4710.0090.14.4571.812<0.0001
800.906−0.0200.12.7022.989<0.0001
FaDuDMSO1.62e−160.0260.19.4711<0.001
100.1050.0170.18.9791.055<0.001
200.2420.0060.17.9871.186<0.001
400.2410.0140.16.8301.387<0.001
600.2820.0130.16.3281.497<0.001
  • NOTE: Table depicts the radiosensitizing activity of the indicated doses of pevonedistat in Cal27 or in FaDu HNSCCs. Values were determined by the survival curves based on the linear quadratic model, using the formula S = e−αD-βD2, where S represents the surviving fraction at 10%, α the linear component of cell killing, β the quadratic component of cell killing, and D the dose of irradiation. SF4 is the surviving fraction at 4 Gy. SER is the sensitizer enhancement ratios for each of the treatment over control (DMSO treatment). Both the SF4 and SER values were calculated from the fitted curves.