Table 1.

Driver gene mutations in ALK expressing melanomas

SampleALK statusSubtypeBRAFNRASKITGNAQGNA11NF1
MB 2141EML4-ALK + ALKATIMucosal
MB 3443ALKATIMucosalQ61H
MB 2724ALKATIAcralP402Ha
MB 3429ALKATINodularG596CR183C
MB 1692ALKATISSAGK-BRAF
MB 2661ALKATI+ wt ALKNodularG466E
MB 2223ALKATI+ wt ALKNodularQ1255Xa
MB 2040wt ALKAcralV600E
MB 1245wt ALKSSV600E
MB 1374wt ALKUnk PriARMC10-BRAF
MB 1588wt ALKUnk PriE844Xa
  • NOTE: “—” indicates no mutation detected.

  • Abbreviations: SS, superficial spreading; Unk Pri, unknown primary.

  • aSpecific mutation has not been functionally characterized.