Table 1.

Potency of PRN1371 in Ba/F3 cells

TargetIC50 ± SD (nmol/L)
FGFR10.7 ± 0.02
FGFR1 (V561M)34.5 ± 2.0
FGFR20.7, <0.6a
FGFR2 (N550K)3.9 ± 1.2
FGFR2 (K660E)1.3, <0.6a
FGFR2 (K660N)0.8, <0.6a
FGFR32.5 ± 0.5
FGFR3 (K650M)3.4 ± 0.5
FGFR449.8 ± 26.0
VEGFR2>2000
CSF1R1,224 ± 792
  • aData from two independent determinations.