Table 1.

Properties of PoP liposomes used in this study

FormulationDox loading (%)Zeta potential (mV)Size (nm)Polydispersity (PDI)Light release of Dox T50% (second)Light release of Dox T90% (second)% Dox release in serum (1 hour)
Neutral95 ± 3−0.9 ± 0.9101 ±20.02 ± 0.0219 ± 0.676 ± 96 ± 0.4
5% DOTAP98 ± 227.1 ± 0.8111 ±70.05 ± 0.0113 ± 2.340 ± 124 ± 0.3
10% DOTAP96 ± 433.9 ± 1.4101 ±10.08 ± 0.019 ± 0.617 ± 17 ± 0.4
20% DOTAP98 ± 247.9 ± 2.3109 ± 100.06 ± 0.035 ± 0.611 ± 37 ± 0.6
30% DOTAP99 ± 247.3 ± 1.299 ± 30.07 ± 0.027 ± 0.015 ± 134 ± 0.9
  • Data show mean ± standard deviation for 3 separate measurements.

  • Light triggered release were performed at 250 mW/cm2 in 50% bovine serum at 37°C. Serum stability were performed in 50% bovine serum at 37°C. Mean ± SD for n = 3.